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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 12
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Research Article

Metabolism of sertindole: identification of the metabolites in the rat and dog, and species comparison of liver microsomal metabolism

K. Sakamoto Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561, Japan
,
Y. Nakamura Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561, Japan
,
S. Aikoh Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561, Japan
,
T. Baba Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561, Japan
,
J. Perregaard Medicinal Chemistry Research, H. Lundbeck A/S, Ottiliavej 9, DK-2500, Copenhagen-Valby, Denmark
,
H. Pedersen Medicinal Chemistry Research, H. Lundbeck A/S, Ottiliavej 9, DK-2500, Copenhagen-Valby, Denmark
,
E. K. Moltzen Medicinal Chemistry Research, H. Lundbeck A/S, Ottiliavej 9, DK-2500, Copenhagen-Valby, Denmark
,
D. J. Mulford Abbott Laboratories, One Abbott Park Road, Abbott Park, IL, 60064-3500, USA
&
T. Yamaguchi Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka, 561, Japan
 show all
Pages 1327-1343 | Received 05 Jun 1995, Published online: 22 Sep 2008

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Stephanie L Cincotta & Joshua S Rodefer. (2010) Emerging role of sertindole in the management of schizophrenia. Neuropsychiatric Disease and Treatment 6, pages 429-441.
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G. J. Dear, I. M. Ismail, P. J. Mutch, R. S. Plumb, L. H. Davies & B. C. Sweatman. (2000) Urinary metabolites of a novel quinoxaline non-nucleoside reverse transcriptase inhibitor in rabbit, mouse and human: identification of fluorine NIH shift metabolites using NMR and tandem MS. Xenobiotica 30:4, pages 407-426.
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Articles from other publishers (16)

Habibur Rahman, S.K. Manirul Haque & Masoom Raza Siddiqui. (2020) A Comprehensive Review on Importance and Quantitation of Atypical Antipsychotic Drugs and their Active Metabolites in Commercial Dosage Forms. Current Pharmaceutical Analysis 16:8, pages 989-1019.
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Massimo Carlo Mauri, Silvia Paletta, Chiara Di Pace, Alessandra Reggiori, Giovanna Cirnigliaro, Isabel Valli & Alfredo Carlo Altamura. (2018) Clinical Pharmacokinetics of Atypical Antipsychotics: An Update. Clinical Pharmacokinetics 57:12, pages 1493-1528.
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Daniel C. Brookings. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 366 407 .
Lisbeth Patteet, Manuel Morrens, Kristof E. Maudens, Peter Niemegeers, Bernard Sabbe & Hugo Neels. (2012) Therapeutic Drug Monitoring of Common Antipsychotics. Therapeutic Drug Monitoring 34:6, pages 629-651.
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Domniki Fragou, Spyridoula Dotsika, Parthena Sarafidou, Victoria Samanidou, Samuel Njau & Leda Kovatsi. (2012) Atypical antipsychotics: trends in analysis and sample preparation of various biological samples. Bioanalysis 4:8, pages 961-980.
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Peter J Mutch, Gordon J Dear & Issy M Ismail. (2001) Formation of a defluorinated metabolite of a quinoxaline antiviral drug catalysed by human cytochrome P450 1A2. Journal of Pharmacy and Pharmacology 53:3, pages 403-408.
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Christoffer Bundgaard, Frank Larsen, Mads Kreilgaard, Lise T. Brennum & Christina Kurre Olsen. (2009) Pharmacokinetics of sertindole and its metabolite dehydrosertindole in rats and characterization of their comparative pharmacodynamics based on in vivo D 2 receptor occupancy and behavioural conditioned avoidance response . Biopharmaceutics & Drug Disposition 30:4, pages 209-220.
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Antonio Párraga, Jörg Holenz & Helmut Buschmann. 2007. Antidepressants, Antipsychotics, Anxiolytics. Antidepressants, Antipsychotics, Anxiolytics 491 616 .
Massimo C Mauri, Lucia S Volonteri, Alessandro Colasanti, Alessio Fiorentini, Ilaria F De Gaspari & Silvio R Bareggi. (2007) Clinical Pharmacokinetics of Atypical Antipsychotics. Clinical Pharmacokinetics 46:5, pages 359-388.
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Mireille Canal‐Raffin, Karine Titier, Evelyne Déridet, Béatrice Martinez, Abdelilah Abouelfath, Alain Miras, Sophie Gromb, Mathieu Molimard & Nicholas Moore. (2006) Myocardium distribution of sertindole and its metabolite dehydrosertindole in guinea‐pigs. Biopharmaceutics & Drug Disposition 27:4, pages 171-179.
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Xavier Subirats, Sigrun Reinstadler, Simo P. Porras, Maria Augusta Raggi & Ernst Kenndler. (2005) Comparison of methanol and acetonitrile as solvents for the separation of sertindole and its major metabolites by capillary zone electrophoresis. ELECTROPHORESIS 26:17, pages 3315-3324.
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Mireille Canal-Raffin, Evelyne Déridet, Karine Titier, Eric Frakra, Mathieu Molimard & Nicholas Moore. (2005) Simplified ultraviolet liquid chromatographic method for determination of sertindole, dehydrosertindole and norsertindole, in human plasma. Journal of Chromatography B 814:1, pages 61-67.
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John S Markowitz, Candace S Brown & Thea R Moore. (2016) Atypical Antipsychotics Part I: Pharmacology, Pharmacokinetics, and Efficacy. Annals of Pharmacotherapy 33:1, pages 73-85.
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Shekman L. Wong & G.Richard Granneman. (1998) Modeling of sertindole pharmacokinetic disposition in healthy volunteers in short term dose-escalation studies. Journal of Pharmaceutical Sciences 87:12, pages 1629-1631.
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Shekman L. Wong, Guoliang Cao, Randall J. Mack, Witt & G. Richard Granneman. (2013) The Effect of Erythromycin on the CYP3A Component of Sertindole Clearance in Healthy Volunteers. The Journal of Clinical Pharmacology 37:11, pages 1056-1061.
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Shekman L. Wong, Guoliang Cao, Randall J. Mack & G. Richard Granneman. (1997) Pharmacokinetics of sertindole in healthy young and elderly male and female subjects*. Clinical Pharmacology & Therapeutics 62:2, pages 157-164.
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