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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 1
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Research Article

Characterization of in vitro metabolites from human liver microsomes using directly coupled hplc-nmr: application to a phenoxathiin monoamine oxidase-A inhibitor

J. P. Shockcor Wellcome Research Laboratories, Research Triangle Park, NC 27706, USA
,
I. S. Silver Wellcome Research Laboratories, Research Triangle Park, NC 27706, USA
,
R. M. Wurm Wellcome Research Laboratories, Research Triangle Park, NC 27706, USA
,
P. N. Sanderson Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, UK
,
R. D. Farrant Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, UK
,
B. C. Sweatman Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, UK
&
J. C. Lindon Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham BR3 3BS, UK
 show all
Pages 41-48 | Published online: 17 Nov 2010

Citations (21)

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John C. Lindon, Jeremy K. Nicholson, Ulla G. Sidelmann & Ian D. Wilson. (1997) Directly Coupled HPLC-NMR and Its Application to Drug Metabolism. Drug Metabolism Reviews 29:3, pages 705-746.
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L. NADELMANN*J. TJORNELUND, S. H. HANSEN, C. CORNETT, U. G. SIDELMANN, U. BRAUMANN, E. CHRISTENSEN & S. B. CHRISTENSEN. (1997) Synthesis, isolation and identification of glucuronides and mercapturic acids of a novel antiparasitic agent, licochalcone A. Xenobiotica 27:7, pages 667-680.
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Articles from other publishers (19)

Maria Victoria Silva Elipe. 2011. LC-NMR and Other Hyphenated NMR Techniques. LC-NMR and Other Hyphenated NMR Techniques 95 130 .
I. Rodríguez, S. Pérez-Rial, J. González-Jimenez, J.M. Pérez-Sánchez, F. Herranz, N. Beckmann & J. Ruíz-Cabello. (2008) Magnetic Resonance Methods and Applications in Pharmaceutical Research. Journal of Pharmaceutical Sciences 97:9, pages 3637-3665.
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John H. Ansede & Dhiren R. Thakker. (2004) High‐throughput screening for stability and inhibitory activity of compounds toward cytochrome P450‐mediated metabolism. Journal of Pharmaceutical Sciences 93:2, pages 239-255.
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Takahiro MURAI, Haruo IWABUCHI & Toshihiko IKEDA. (2004) Identification of Gemfibrozil Metabolites, Produced as Positional Isomers in Human Liver Microsomes, by On-line Analyses Using Liquid Chromatography/Mass Spectrometry and Liquid Chromatography/Nuclear Magnetic Resonance Spectroscopy. Journal of the Mass Spectrometry Society of Japan 52:5, pages 277-283.
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Maria Victoria Silva Elipe. (2003) Advantages and disadvantages of nuclear magnetic resonance spectroscopy as a hyphenated technique. Analytica Chimica Acta 497:1-2, pages 1-25.
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Olivia Corcoran & Manfred Spraul. (2003) LC–NMR–MS in drug discovery. Drug Discovery Today 8:14, pages 624-631.
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John C. Lindon, Nigel J.C. Bailey, Jeremy K. Nicholson & Ian D. Wilson. 2003. Bioanalytical Separations. Bioanalytical Separations 293 329 .
Hong Kim, Wenqing Feng, Tze-Ming Chan, Diane Rindgen, Matthew Bryant, Kathleen A. Cox, Yan Xia, Gregory Reichard, Sunil Paliwal, David Hesk, Jairam Palamanda, Ronald E. White & Amin A. Nomeir. (2002) Isolation of circulating metabolites in drug discovery using high-performance liquid chromatography, and their identification by liquid chromatography coupled with tandem mass spectrometry and nuclear magnetic resonance spectroscopy. Journal of Separation Science 25:14, pages 877-882.
Crossref
Steven H HokeIIII, Kenneth L Morand, Kenneth D Greis, Timothy R Baker, Kevin L Harbol & Roy L.M Dobson. (2001) Transformations in pharmaceutical research and development, driven by innovations in multidimensional mass spectrometry-based technologies. International Journal of Mass Spectrometry 212:1-3, pages 135-196.
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Sean X Peng. (2001) Separation and identification methods for metalloproteinase inhibitors. Journal of Chromatography B: Biomedical Sciences and Applications 764:1-2, pages 59-80.
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Wenqing Feng, Haiying Liu, Guodong Chen, Rodney Malchow, Frank Bennett, Elizabeth Lin, Birendra Pramanik & Tze-Ming Chan. (2001) Structural characterization of the oxidative degradation products of an antifungal agent SCH 56592 by LC–NMR and LC–MS. Journal of Pharmaceutical and Biomedical Analysis 25:3-4, pages 545-557.
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John C Lindon, Jeremy K Nicholson & Ian D Wilson. (2000) Directly coupled HPLC–NMR and HPLC–NMR–MS in pharmaceutical research and development. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 233-258.
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Sean X. Peng. (2000) Hyphenated HPLC-NMR and its applications in drug discovery. Biomedical Chromatography 14:6, pages 430-441.
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M.J Shapiro & J.S Gounarides. (1999) NMR methods utilized in combinatorial chemistry research. Progress in Nuclear Magnetic Resonance Spectroscopy 35:2, pages 153-200.
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Sean X Peng, Babul Borah, Roy L.M Dobson, Y.Diana Liu & Stanislaw Pikul. (1999) Application of LC-NMR and LC-MS to the identification of degradation products of a protease inhibitor in dosage formulations. Journal of Pharmaceutical and Biomedical Analysis 20:1-2, pages 75-89.
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R. S. Plumb, J. Ayrton, G. J. Dear, B. C. Sweatman & I. M. Ismail. (1999) The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry. Rapid Communications in Mass Spectrometry 13:10, pages 845-854.
Crossref
John S. Gounarides, Aidi Chen & Michael J. Shapiro. (1999) Nuclear magnetic resonance chromatography: applications of pulse field gradient diffusion NMR to mixture analysis and ligand–receptor interactions. Journal of Chromatography B: Biomedical Sciences and Applications 725:1, pages 79-90.
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Olivia Corcoran, Manfred Spraul, Martin Hofmann, Ismail M Ismail, John C Lindon & Jeremy K Nicholson. (1997) 750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines. Journal of Pharmaceutical and Biomedical Analysis 16:3, pages 481-489.
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R.Duncan Farrant, Belinda C. Cupid, Jeremy K. Nicholson & John C. Lindon. (1997) Investigation of the feasibility of directly-coupled HPLC-NMR with 2H detection with application to the metabolism of N-dimethylformamide-d7. Journal of Pharmaceutical and Biomedical Analysis 16:1, pages 1-5.
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