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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 2
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Research Article

Hplc-nmr identification of the human urinary metabolites of (—)-cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl] cytosine, a nucleoside analogue active against human immunodeficiency virus (HIV)

J. P. Shockcor Wellcome Research Laboratories, Research Triangle Park NC, 32, USA
,
R. M. Wurm Wellcome Research Laboratories, Research Triangle Park NC, 32, USA
,
L. W. Frick Wellcome Research Laboratories, Research Triangle Park NC, 32, USA
,
P. N. Sanderson Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham, BR3 3BS, UK
,
R. D. Farrant Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham, BR3 3BS, UK
,
B. C. Sweatman Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham, BR3 3BS, UK
&
J. C. Lindon Department of Physical Sciences, Wellcome Research Laboratories, Langley Court, Beckenham, BR3 3BS, UK
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Pages 189-199 | Received 20 Aug 1995, Published online: 22 Sep 2008

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A. E. Mutlib, S. Diamond, J. Shockcor, R. Way, G. Nemeth, L. Gan & D. D. Christ. (2000) Mass spectrometric and NMR characterization of metabolites of roxifiban, a potent and selective antagonist of the platelet glycoprotein IIb/IIIa receptor. Xenobiotica 30:11, pages 1091-1110.
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John C. Lindon, Jeremy K. Nicholson, Ulla G. Sidelmann & Ian D. Wilson. (1997) Directly Coupled HPLC-NMR and Its Application to Drug Metabolism. Drug Metabolism Reviews 29:3, pages 705-746.
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Articles from other publishers (22)

Ghulam Shabir, Aamer Saeed, Wajeeha Zahid, Fatima Naseer, Zainab Riaz, Nafeesa Khalil, Muneeba & Fernando Albericio. (2023) Chemistry and Pharmacology of Fluorinated Drugs Approved by the FDA (2016–2022). Pharmaceuticals 16:8, pages 1162.
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J.P. Shockcor. 2017. Encyclopedia of Spectroscopy and Spectrometry. Encyclopedia of Spectroscopy and Spectrometry 141 151 .
Alexander V. LyubimovMichael D. Reily, Stella Huang, Janet Caceres‐Cortes, Kim Johnson & Yue‐Zhong Shu. 2011. Encyclopedia of Drug Metabolism and Interactions. Encyclopedia of Drug Metabolism and Interactions 1 29 .
J.P. Shockcor. 2010. Encyclopedia of Spectroscopy and Spectrometry. Encyclopedia of Spectroscopy and Spectrometry 946 956 .
Elaine HolmesRuey Leng LooOlivier CloarecMuireann CoenHuiru TangElaine MaibaumStephen BruceQueenie ChanPaul ElliottJeremiah StamlerIan D. WilsonJohn C. LindonJeremy K. Nicholson. (2007) Detection of Urinary Drug Metabolite (Xenometabolome) Signatures in Molecular Epidemiology Studies via Statistical Total Correlation (NMR) Spectroscopy. Analytical Chemistry 79:7, pages 2629-2640.
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E. Littler & X.-X. Zhou. 2007. Comprehensive Medicinal Chemistry II. Comprehensive Medicinal Chemistry II 295 327 .
Abdul Mutlib, Wing Lam, Jim Atherton, Hao Chen, Paul Galatsis & Wayne Stolle. (2005) Application of stable isotope labeled glutathione and rapid scanning mass spectrometers in detecting and characterizing reactive metabolites. Rapid Communications in Mass Spectrometry 19:23, pages 3482-3492.
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John Shockcor & Ian Wilson. 2005. Metabonomics in Toxicity Assessment. Metabonomics in Toxicity Assessment 225 262 .
John H. Ansede & Dhiren R. Thakker. (2004) High‐throughput screening for stability and inhibitory activity of compounds toward cytochrome P450‐mediated metabolism. Journal of Pharmaceutical Sciences 93:2, pages 239-255.
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Ian D. Wilson. 2004. Chromatography 6th Edition - Fundamentals and Applications of Chromatography and Related Differential Migration Methods. Chromatography 6th Edition - Fundamentals and Applications of Chromatography and Related Differential Migration Methods 945 985 .
R.D Combes, T Berridge, J Connelly, M.D Eve, R.C Garner, S Toon & P Wilcox. (2003) Early microdose drug studies in human volunteers can minimise animal testing: Proceedings of a workshop organised by Volunteers in Research and Testing. European Journal of Pharmaceutical Sciences 19:1, pages 1-11.
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John C. Lindon, Nigel J.C. Bailey, Jeremy K. Nicholson & Ian D. Wilson. 2003. Bioanalytical Separations. Bioanalytical Separations 293 329 .
Wenqing Feng, Haiying Liu, Guodong Chen, Rodney Malchow, Frank Bennett, Elizabeth Lin, Birendra Pramanik & Tze-Ming Chan. (2001) Structural characterization of the oxidative degradation products of an antifungal agent SCH 56592 by LC–NMR and LC–MS. Journal of Pharmaceutical and Biomedical Analysis 25:3-4, pages 545-557.
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John P Shockcor, Steve E Unger, Paul Savina, Jeremy K Nicholson & John C Lindon. (2000) Application of directly coupled LC–NMR–MS to the structural elucidation of metabolites of the HIV-1 reverse-transcriptase inhibitor BW935U83. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 269-279.
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John C Lindon, Jeremy K Nicholson & Ian D Wilson. (2000) Directly coupled HPLC–NMR and HPLC–NMR–MS in pharmaceutical research and development. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 233-258.
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G.J. Dear, R.S. Plumb, B.C. Sweatman, J. Ayrton, J.C. Lindon, J.K. Nicholson & I.M. Ismail. (2000) Mass directed peak selection, an efficient method of drug metabolite identification using directly coupled liquid chromatography–mass spectrometry–nuclear magnetic resonance spectroscopy. Journal of Chromatography B: Biomedical Sciences and Applications 748:1, pages 281-293.
Crossref
R. S. Plumb, J. Ayrton, G. J. Dear, B. C. Sweatman & I. M. Ismail. (1999) The use of preparative high performance liquid chromatography with tandem mass spectrometric directed fraction collection for the isolation and characterisation of drug metabolites in urine by nuclear magnetic resonance spectroscopy and liquid chromatography/sequential mass spectrometry. Rapid Communications in Mass Spectrometry 13:10, pages 845-854.
Crossref
I Wilson, J Nicholson & J Lindon. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 523 550 .
Paul A Keifer. (1999) NMR tools for biotechnology. Current Opinion in Biotechnology 10:1, pages 34-41.
Crossref
John C. Lindon, Jeremy K. Nicholson & Jeremy R. Everett. 1999. Annual Reports on NMR Spectroscopy Volume 38. Annual Reports on NMR Spectroscopy Volume 38 1 88 .
J.P. Shockcor. 1999. Encyclopedia of Spectroscopy and Spectrometry. Encyclopedia of Spectroscopy and Spectrometry 301 310 .
R.Duncan Farrant, Belinda C. Cupid, Jeremy K. Nicholson & John C. Lindon. (1997) Investigation of the feasibility of directly-coupled HPLC-NMR with 2H detection with application to the metabolism of N-dimethylformamide-d7. Journal of Pharmaceutical and Biomedical Analysis 16:1, pages 1-5.
Crossref

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