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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 3
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Research Article

Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals

W. F. Richter Pharma Division, Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
,
B. R. Whitby Department of Drug Metabolism, Corning Hazleton, Otley Road, Harrogate, HG3 1PY, UK
&
R. C. Chou Pharma Division, Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
Pages 243-254 | Received 20 Jul 1995, Published online: 22 Sep 2008

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Hernán Trimarchi. (2011) Role of aliskiren in blood pressure control and renoprotection. International Journal of Nephrology and Renovascular Disease 4, pages 41-48.
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Jürgen Maibaum & David L Feldman. (2003) Renin inhibitors as novel treatments for cardiovascular disease. Expert Opinion on Therapeutic Patents 13:5, pages 589-603.
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Articles from other publishers (18)

Alexander N Reznikov, Anastasiya E Sibiryakova, Marat R Baimuratov, Eugene V Golovin, Victor B Rybakov & Yuri N Klimochkin. (2019) Synthesis of non-racemic 4-nitro-2-sulfonylbutan-1-ones via Ni(II)-catalyzed asymmetric Michael reaction of β-ketosulfones. Beilstein Journal of Organic Chemistry 15, pages 1289-1297.
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Christian Simon Gloor, Fabrice Dénès & Philippe Renaud. (2017) Hydrosulfonylation Reaction with Arenesulfonyl Chlorides and Tetrahydrofuran: Conversion of Terminal Alkynes into Cyclopentylmethyl Sulfones. Angewandte Chemie International Edition 56:43, pages 13329-13332.
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Christian Simon Gloor, Fabrice Dénès & Philippe Renaud. (2017) Hydrosulfonylation Reaction with Arenesulfonyl Chlorides and Tetrahydrofuran: Conversion of Terminal Alkynes into Cyclopentylmethyl Sulfones. Angewandte Chemie 129:43, pages 13514-13517.
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Kazal B. BiswasA.H.M.N. Nabi, Akio Ebihara, Tsutomu Nakagawa, Arunasiri IddamalgodaFumiaki Suzuki. (2014) RENIN ANGIOTENSIN SYSTEM-DEPENDENT AND -INDEPENDENT FUNCTIONS OF (PRO)RENIN RECEPTOR AND THE ROLES OF ITS BLOCKERS. Reviews in Agricultural Science 2:0, pages 37-47.
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David L. FeldmanLiang JinHong XuanElke PersohnWei ZhouHelmut SchuetzJoon-Keun Park, Dominik N. Muller & Friedrich C. Luft. (2013) The direct renin inhibitor aliskiren localizes and persists in rat kidneys. American Journal of Physiology-Renal Physiology 305:11, pages F1593-F1602.
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Randy L. Webb, Nikolaus Schiering, Richard Sedrani & Jürgen Maibaum. (2010) Direct Renin Inhibitors as a New Therapy for Hypertension. Journal of Medicinal Chemistry 53:21, pages 7490-7520.
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Donald J. AbrahamColin M. Tice, Gerard M. McGeehan & David A. Claremon. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 239 266 .
Colin M. Tice & Suresh B. Singh. 2010. Aspartic Acid Proteases as Therapeutic Targets. Aspartic Acid Proteases as Therapeutic Targets 297 324 .
Jeanette M. Wood & Jürgen Maibaum. 2010. Aspartic Acid Proteases as Therapeutic Targets. Aspartic Acid Proteases as Therapeutic Targets 263 296 .
Zafar H Israili, Manuel Velasco & Valmore Bermúdez. (2010) Direct Renin Inhibitors as Antihypertensive Agents. American Journal of Therapeutics 17:3, pages 237-254.
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David L Feldman. (2010) New insights into the renoprotective actions of the renin inhibitor aliskiren in experimental renal disease. Hypertension Research 33:4, pages 279-287.
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Hernán Trimarchi & Marcelo Orías. (2014) Aliskiren and the Kidney: Beyond Hypertension. Nephrology Research & Reviews 1:1, pages 1-4.
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Jürgen Maibaum & David L. Feldman. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 105 127 .
Terry C. Major, Bronia Olszewski, Wendy Rosebury, Carlin Okerberg, Tage Carlson, Robert Ostroski, Richard Schroeder, Mark C. Kowala & Robert Leadley. (2008) A Nonpeptide, Piperidine Renin Inhibitor Provides Renal and Cardiac Protection in Double-Transgenic Mice Expressing Human Renin and Angiotensinogen Genes. Cardiovascular Drugs and Therapy 22:6, pages 469-478.
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Duncan J. Campbell. (2008) Interpretation of Plasma Renin Concentration in Patients Receiving Aliskiren Therapy. Hypertension 51:1, pages 15-18.
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Jan A Staessen, Yan Li & Tom Richart. (2006) Oral renin inhibitors. The Lancet 368:9545, pages 1449-1456.
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Pieter van Paassen, Dick de Zeeuw, Gerjan Navis & Paul E. de Jong. (2000) Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function. Nephrology Dialysis Transplantation 15:5, pages 637-643.
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Jürgen BohlenderJoël MénardDetlev GantenFriedrich C. Luft. (2000) Angiotensinogen Concentrations and Renin Clearance. Hypertension 35:3, pages 780-786.
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