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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 3
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Research Article

Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates

Ph. Coassolo Pharma Division Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
,
W. Fischli Pharma Division Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
,
J-P. Clozel Pharma Division Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
&
R. C. Chou Pharma Division Preclinical Research, F. Hoffmann-La Roche AG, CH-4002, Basel, Switzerland
Pages 333-345 | Received 20 Jul 1995, Published online: 22 Sep 2008

Citations (11)

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W. F. Richter, B. R. Whitby & R. C. Chou. (1996) Distribution of remikiren, a potent orally active inhibitor of human renin, in laboratory animals. Xenobiotica 26:3, pages 243-254.
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Articles from other publishers (10)

Donald J. AbrahamColin M. Tice, Gerard M. McGeehan & David A. Claremon. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 239 266 .
Colin M. Tice & Suresh B. Singh. 2010. Aspartic Acid Proteases as Therapeutic Targets. Aspartic Acid Proteases as Therapeutic Targets 297 324 .
Iftekhar Mahmood. (2009) Role of Fixed Coefficients and Exponents in the Prediction of Human Drug Clearance: How Accurate are the Predictions from One or Two Species?. Journal of Pharmaceutical Sciences 98:7, pages 2472-2493.
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Jürgen Maibaum & David L. Feldman. 2009. Annual Reports in Medicinal Chemistry Volume 44. Annual Reports in Medicinal Chemistry Volume 44 105 127 .
Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Teh-Min Hu & William L. Hayton. (2015) Allometric scaling of xenobiotic clearance: Uncertainty versus universality. AAPS PharmSci 3:4, pages 30-43.
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Pieter van Paassen, Dick de Zeeuw, Gerjan Navis & Paul E. de Jong. (2000) Renal and systemic effects of continued treatment with renin inhibitor remikiren in hypertensive patients with normal and impaired renal function. Nephrology Dialysis Transplantation 15:5, pages 637-643.
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I. Mahmood. (2000) Can Absolute Oral Bioavailability in Humans be Predicted from Animals? A Comparison of Allometry and Different Indirect Methods. Drug Metabolism and Drug Interactions 16:2.
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Eero M. A. MervaalaDominik N. MüllerJoon-Keun ParkFolke SchmidtMatthias LöhnVolker BreuDuska DragunDetlev GantenHerman HallerFriedrich C. Luft. (1999) Monocyte Infiltration and Adhesion Molecules in a Rat Model of High Human Renin Hypertension. Hypertension 33:1, pages 389-395.
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