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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 4
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Research Article

Pharmacokinetics and metabolism of zamifenacin in mouse, rat, dog and man

K. C. Beaumont Department of Drug Metabolism, Pfizer Central Research, Sandwich, CT13 9NJ, UK
,
A. G. Causey Department of Drug Metabolism, Pfizer Central Research, Sandwich, CT13 9NJ, UK
,
P. E. Coates Department of Drug Metabolism, Pfizer Central Research, Sandwich, CT13 9NJ, UK
&
D. A. Smith Department of Drug Metabolism, Pfizer Central Research, Sandwich, CT13 9NJ, UK
Pages 459-471 | Received 05 Aug 1995, Published online: 22 Sep 2008

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S. J. Enoch & M. T. D. Cronin. (2010) A review of the electrophilic reaction chemistry involved in covalent DNA binding. Critical Reviews in Toxicology 40:8, pages 728-748.
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R. Webster, G. Allan, K. Anto-Awuakye, A. Harrison, T. Kidd, D. Leishman, J. Phipps & D. Walker. (2001) Pharmacokinetic/pharmacodynamic assessment of the effects of E4031, cisapride, terfenadine and terodiline on monophasic action potential duration in dog. Xenobiotica 31:8-9, pages 633-650.
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D. E. AMACHER, L. M. FASULO, C. CHARUEL, P. COMBY & K. BEAUMONT. (1998) In vitro toxicity of zamifenacin (UK-76,654) and metabolites in primary hepatocyte cultures. Xenobiotica 28:9, pages 895-908.
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Akinori Takemura, Simin Gong, Tomoyuki Sato, Moemi Kawaguchi, Shuichi Sekine, Yasuhiro Kazuki, Toru Horie & Kousei Ito. (2021) Evaluation of Parent- and Metabolite-Induced Mitochondrial Toxicities Using CYP-Introduced HepG2 cells. Journal of Pharmaceutical Sciences 110:9, pages 3306-3312.
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Barbara A. Wetmore, John F. Wambaugh, Brittany Allen, Stephen S. Ferguson, Mark A. Sochaski, R. Woodrow Setzer, Keith A. Houck, Cory L. Strope, Katherine Cantwell, Richard S. Judson, Edward LeCluyse, Harvey J. Clewell, Russell S. Thomas & Melvin E. Andersen. (2015) Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing . Toxicological Sciences 148:1, pages 121-136.
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Nicola Colclough, Linette Ruston, J. Matthew Wood & Philip A. MacFaul. (2014) Species differences in drug plasma protein binding. Med. Chem. Commun. 5:7, pages 963-967.
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Jianghong Fan & Inés A.M. de Lannoy. (2014) Pharmacokinetics. Biochemical Pharmacology 87:1, pages 93-120.
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. 2012. Pharmacokinetics and Metabolism in Drug Design. Pharmacokinetics and Metabolism in Drug Design 209 227 .
Ying Zhang, Lili Yao, Jing Lin, Hua Gao, Theresa C. Wilson & Craig Giragossian. (2010) Lack of Appreciable Species Differences in Nonspecific Microsomal Binding. Journal of Pharmaceutical Sciences 99:8, pages 3620-3627.
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J. Matthew Hutzler, Roger J. Melton, Jeanne M. Rumsey, David C. Thompson, Dan A. Rock & Larry C. Wienkers. (2008) Assessment of the Metabolism and Intrinsic Reactivity of a Novel Catechol Metabolite. Chemical Research in Toxicology 21:5, pages 1125-1133.
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James T. Limberis, Jeff S. McDermott, Heinz J. Salmen, Zhi Su, Ann Mikhail, Jonathon R. Green, Bryan F. Cox, Gary A. Gintant & Ruth L. Martin. (2007) The effects of plasma proteins on delayed repolarization in vitro with cisapride, risperidone, and d, l-sotalol. Journal of Pharmacological and Toxicological Methods 56:1, pages 11-17.
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Han van de Waterbeemd. (2005) Which in vitro Screens Guide the Prediction of Oral Absorption and Volume of Distribution?. Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology 96:3, pages 162-166.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Catinella Silvia, Pelizzi Nicola, Puccini Paola, Marchetti Silvia, Zanol Margherita, Acerbi Daniela & Ventura Paolo. (2001) Phase I metabolism of ganstigmine. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry. Journal of Mass Spectrometry 36:12, pages 1287-1293.
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Han van de WaterbeemdDennis A. SmithKevin BeaumontDon K. Walker. (2001) Property-Based Design:  Optimization of Drug Absorption and Pharmacokinetics. Journal of Medicinal Chemistry 44:9, pages 1313-1333.
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Olivia Corcoran, Manfred Spraul, Martin Hofmann, Ismail M Ismail, John C Lindon & Jeremy K Nicholson. (1997) 750 MHz HPLC-NMR spectroscopic identification of rat microsomal metabolites of phenoxypyridines. Journal of Pharmaceutical and Biomedical Analysis 16:3, pages 481-489.
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Janine Cossy, Cécile Dumas & Domingo Gomez Pardo. (1997) A SHORT AND EFFICIENT SYNTHESIS OF ZAMIFENACIN A MUSCARINIC M3 RECEPTOR ANTAGONIST. Bioorganic & Medicinal Chemistry Letters 7:10, pages 1343-1344.
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