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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 6
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Research Article

Absorption, metabolism and excretion of tamsulosin hydrochloride in man

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Pages 637-645 | Received 02 Jan 1996, Published online: 22 Sep 2008

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Read on this site (4)

Denise Kreutzwiser & Alice Tseng. (2016) Drug interactions between antiretrovirals and drugs used to treat benign prostatic hyperplasia/lower urinary tract symptoms. Expert Opinion on Drug Metabolism & Toxicology 12:10, pages 1211-1224.
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Bob Djavan, Markus Johannes Handl & Saeid Dianat. (2010) Combined medical treatment using dutasteride and tamsulosin for lower urinary tract symptoms suggestive of benign prostatic hyperplasia. Expert Opinion on Pharmacotherapy 11:15, pages 2535-2547.
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Martin C Michel & Jean JMCH de la Rosette. (2004) Efficacy and safety of tamsulosin in the treatment of urological diseases. Expert Opinion on Pharmacotherapy 5:1, pages 151-160.
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H. KAMIMURA, S. OISHIOE, H. MATSUSHIMA, T. WATANABE, S. HIGUCHI, M. HALL, S. G. WOOD & L. F. CHASSEAUD. (1998) Identification of cytochrome P450 isozymes involved in metabolism of the α1-adrenoceptor blocker tamsulosin in human liver microsomes. Xenobiotica 28:10, pages 909-922.
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Articles from other publishers (24)

Chang‑Keun Cho, Pureum Kang, Hye-Jung Park, Yun Jeong Lee, Jung‑Woo Bae, Choon-Gon Jang & Seok-Yong Lee. (2021) Physiologically based pharmacokinetic (PBPK) modelling of tamsulosin related to CYP2D6*10 allele. Archives of Pharmacal Research 44:11, pages 1037-1049.
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Shereen A. Boltia, Mohammed Abdelkawy, Taghreed A. Mohamed & Nahla N. Mostafa. (2021) Optimized ion selective electrode for determination of Tamsulosin hydrochloride in the presence of co-formulated Deflazacort in bulk, tablet dosage form and human urine. Microchemical Journal 163, pages 105936.
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Ya-Ping Li, Ying Yang, Mu-Qi Wang, Xin Zhang, Wen-Jun Wang, Mei Li, Feng-Ping Wu & Shuang-Suo Dang. (2020) Facial and bilateral lower extremity edema due to drug-drug interactions in a patient with hepatitis C virus infection and benign prostate hypertrophy: A case report. World Journal of Clinical Cases 8:15, pages 3372-3376.
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Kyoung-Ah Kim, In-Bae Park & Ji-Young Park. (2018) Effects of CYP2D6 and CYP3A5 genetic polymorphisms on steady-state pharmacokinetics and hemodynamic effects of tamsulosin in humans. European Journal of Clinical Pharmacology 74:10, pages 1281-1289.
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Ji-Yeong Byeon, Yun Jeong Lee, Young-Hoon Kim, Se-Hyung Kim, Choong-Min Lee, Jung-Woo Bae, Choon-Gon Jang, Seok-Yong Lee & Chang-Ik Choi. (2018) Effects of diltiazem, a moderate inhibitor of CYP3A4, on the pharmacokinetics of tamsulosin in different CYP2D6 genotypes. Archives of Pharmacal Research 41:5, pages 564-570.
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M.C. Michel. 2017. Reference Module in Biomedical Sciences. Reference Module in Biomedical Sciences.
Huafang Li, Jiansong Yang, Hongxin Zhao, Michael J. Fossler & Chunrong Wang. (2015) Effect of tamsulosin on the pharmacokinetics of dutasteride in Chinese male healthy volunteers. Clinical Pharmacology in Drug Development 4:6, pages 427-433.
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Abdul Naveed Shaik. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Yigit Akin, Hakan Gulmez, Murat Ucar & Selcuk Yucel. (2013) The effect of first dose of tamsulosin on flow rate and its predictive ability on the improvement of LUTS in men with BPH in the mid-term. International Urology and Nephrology 45:1, pages 45-51.
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Dean S Elterman, Bilal Chughtai, Steven A Kaplan & Jack Barkin. (2012) Combination treatment with tamsulosin and dutasteride for benign prostatic hyperplasia. Aging Health 8:6, pages 555-565.
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Chang‐Ik Choi, Jung‐Woo Bae, Choon‐Gon Jang & Seok‐Yong Lee. (2013) Tamsulosin Exposure Is Significantly Increased by the CYP2D6*10/*10 Genotype . The Journal of Clinical Pharmacology 52:12, pages 1934-1938.
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Chang-Ik Choi, Hye-In Lee, Jung-Woo Bae, Yun-Jeong Lee, Ji-Yeong Byeon, Choon-Gon Jang & Seok-Yong Lee. (2012) Determination of tamsulosin in human plasma by liquid chromatography/tandem mass spectrometry and its application to a pharmacokinetic study. Journal of Chromatography B 909, pages 65-69.
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Amit S. Kalgutkar, Deepak Dalvie, R. Scott Obach & Dennis A. Smith. 2012. Reactive Drug Metabolites. Reactive Drug Metabolites 269 312 .
Gillian M. Keating. (2012) Dutasteride/Tamsulosin. Drugs & Aging 29:5, pages 405-419.
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Antonia F. Stepan, Daniel P. Walker, Jonathan Bauman, David A. Price, Thomas A. Baillie, Amit S. Kalgutkar & Michael D. Aleo. (2011) Structural Alert/Reactive Metabolite Concept as Applied in Medicinal Chemistry to Mitigate the Risk of Idiosyncratic Drug Toxicity: A Perspective Based on the Critical Examination of Trends in the Top 200 Drugs Marketed in the United States. Chemical Research in Toxicology 24:9, pages 1345-1410.
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Joachim Troost, Shinji Tatami, Yasuhiro Tsuda, Michaela Mattheus, Ludwig Mehlburger, Martina Wein & Martin C. Michel. (2011) Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin. British Journal of Clinical Pharmacology 72:2, pages 247-256.
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Gabriela Franco-Salinas, Jean J.M.C.H. de la Rosette & Martin C. Michel. (2010) Pharmacokinetics and Pharmacodynamics of Tamsulosin in its Modified-Release and Oral Controlled Absorption System Formulations. Clinical Pharmacokinetics 49:3, pages 177-188.
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Marleen M van Dijk, Jean JMCH de la Rosette & Martin C Michel. (2006) Tamsulosin - modified-release and oral-controlled absorption system formulations in the treatment of benign prostatic hyperplasia. Therapy 3:2, pages 237-246.
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Donald J. AbrahamRobert K. Griffith. 2003. Burger's Medicinal Chemistry and Drug Discovery. Burger's Medicinal Chemistry and Drug Discovery 1 37 .
Katherine A. Lyseng-Williamson, Blair Jarvis & Antona J. Wagstaff. (2002) Tamsulosin. Drugs 62:1, pages 135-167.
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Christopher J. Dunn, Anna Matheson & Diana M. Faulds. (2002) Tamsulosin. Drugs & Aging 19:2, pages 135-161.
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Franz von Bruchhausen, Siegfried Ebel, Eberhard Hackenthal, Ulrike Holzgrabe, Margitta Albinus, Gudrun Amschler, Erwin von Angerer, C. Arras-Reiter, Andrea Bauer, Pia Bauer, Winfried Beil, Thorsten Beyrich, Katja Binder, Roswitha Böhme, Hans-Hubertus Borchert, Franz Bossle, Franz Bracher, Helmut Bräunlich, Ellen Bretschneider, Regina Brigelius-Flohé, Kerstin Brinkmann, Axel Büge, Wolfram Christ, Monika Cimbollek, Rolf Daniels, Gerd Dannhardt, Hans-Jürgen Duchstein, Kurt Eger, Petra Eichhorn, Michael Engler, Thomas Erker, Peter Felfe, Alfred Fenyves, Reinhard Fescharek, Carmen Frackenpohl, August Wilhelm Frahm, Margarete Frahm, Volker Franke, Ulrich Franken, Detlef Geffken, Uli Geis, Erika Glusa, Berthold Göber, Peter Ndive Gobina, Werner Golder, Margarete Goppelt-Strübe, Katharina Götte, Erkme Gottstein, Michael Grosam, Markus von Gruchalla, Michael Gütschow, Annette Häfner, Boris Haluszczynski, Achim Harder, Sabine Hartmann, Susanne Hartmann, Dieter Heber, Gerhard Heinemeyer, Eberhard Heller, Dietrich von Herrath, J. Hilfenhaus, Ute Hoffmann-Schollmayer, Bernhard Hofmann, Christian Holpert, Ute Hübner-Steiner, Elisabeth Inkmann, Jens Jürgens, Brigitte Kaiser, Dieter-Abbo Kalbhen, Hans Kemmler, Werner Kiefer, Christoph Klett, Stephanie Klett, Martin Klingmüller, Hans-Peter Klöcking, Gerd Kobal, Axel Kramer, Mareta Kreher, M. Krüger, Markus Kuhn, Marion Sylvia Lehner, Detlef Leopoldt, Georg Liedtke, Detlef Manns, Wolfgang Matthiessen, Andreas Maurer, Wolfgang Meindl, Klaus Menges, Paul Messinger, Frank Peter Meyer, Wolfgang Meyerhof, Manfred Moos, Rudolf Morgenstern, Klaus Müller, Walter E. Müller, Corina Nachtsheim, Tilo Netzer, Michael Neugebauer, Werner Neupert, Peter Nickel, Peter Nuhn, Bernd Nürnberg, H. Oelschläger, Joachim Oertel, Michael Oettel, Hartmut Oßwald, Robert Ott, Tilmann Ott, Thomas Otzen, Peter Pachaly, Helmut Pelzer, Karl-Uwe Petersen, Rainer Pick, Martina Pickert, Andreas Pies, Eberhard Reimann, Joachim Richter, Kai Riecke, Suzanne Ritter, Hans Rommelspacher, Ulrich Rose, Gernot Roth, Gerhard Rücker, Judith Schäfer, Joachim G. Schantl, Helmut Schlager, Hildegard Schleinitz, Max Schmauß, Helmut Schmidhammer, Gerhard Schmidt, Timo Schmidt, B. Schneeweiß, Johannes Schräder, Thomas Schulz, Gert Schulze, Peter Schwanz, Johannes Schweiger, Gisela Skopp, Gisela Skorka, Kai Smolinka, Ulrich Speck, Ralf Stahlmann, Herbert Stein, Karlheinz Stiefvater, Karl-Heinz Surborg, Ulf Sürig, Hubert Szelényi, Istvan Szelenyi, Alfred Täufel, Ruth Thieroff-Ekerdt, Reinhard Troschütz, Michael Verborg, Eugen J. Verspohl, Sabine Vogel, Franz-Josef Volk, Thomas Vorwerk, Jürgen Wallmann, Martin Wenzel, Marion Weyandt-Spangenberg, Sandra Wich, Reinhold Wintersteiger, Frauke Woltmann, Beate Wüst, G. Zilow & A. Kluge. 1999. Hagers Handbuch der Pharmazeutischen Praxis. Hagers Handbuch der Pharmazeutischen Praxis 607 701 .
Katsunari Taguchi, Rafael F. Schäfers & Martin C. Michel. (2002) Radioreceptor assay analysis of tamsulosin and terazosin pharmacokinetics. British Journal of Clinical Pharmacology 45:1, pages 49-55.
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Ewoud J. Van Hoogdalem, Yoshiaki Soeishi, Hiroshi Matsushima & Saburo Higuchi. (1997) Disposition of the Selective α1A-Adrenoceptor Antagonist Tamsulosin in Humans: Comparison with Data from Interspecies Scaling. Journal of Pharmaceutical Sciences 86:10, pages 1156-1161.
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