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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 6
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Research Article

Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol

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Pages 647-666 | Received 12 Dec 1995, Published online: 22 Sep 2008

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Corwin Hansch, Suresh Babu Mekapati, Alka Kurup & Rajeshwar Prasad Verma. (2004) QSAR of Cytochrome P450. Drug Metabolism Reviews 36:1, pages 105-156.
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Jos G. M. Bessems & Nico P. E. Vermeulen. (2001) Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches. Critical Reviews in Toxicology 31:1, pages 55-138.
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Articles from other publishers (10)

Huachang Hong, Yuchen Lu, Xiaoyan Zhu, Qiang Wu, Lingmin Jin, Zhigang Jin, Xiaoxuan Wei, Guangcai Ma & Haiying Yu. (2023) Cytotoxicity of nitrogenous disinfection byproducts: A combined experimental and computational study. Science of The Total Environment 856, pages 159273.
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Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater & Paul Jennings. (2022) “ Commandeuring ” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism . Chemical Research in Toxicology 35:7, pages 1184-1201.
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Jeff B. Helms, Lauren P. Saunders, Jamie Meyer, Charles J. Costa, Eric Plowman, Nick Williford, Matthew Corbitt, Jeremy P. Holden & Craig Gatto. (2015) Kinetic Characterization of Na,K-ATPase Inhibition by the Acetaminophen Metabolite N-Acetylbenzoquinoneimine. Open Journal of Molecular and Integrative Physiology 05:01, pages 1-17.
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André LeBlanc, Tze Chieh Shiao, René Roy & Lekha Sleno. (2014) Absolute Quantitation of NAPQI-Modified Rat Serum Albumin by LC–MS/MS: Monitoring Acetaminophen Covalent Binding in Vivo . Chemical Research in Toxicology 27:9, pages 1632-1639.
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Luana M. D. Queiroz, Josmar R. Rocha, Andrei Leit?o, Carlos A. Montanari, Alb?rico B. F. da Silva, Pergentino J. C. Sousa & Rosivaldo S. Borges. (2012) A Combined Study Using Ligand-Based Design, Synthesis, and Pharmacological Evaluation of Analogues of the Acetaminophen Ortho-Regioisomer with Potent Analgesic Activity. Chemical Biology & Drug Design 80:1, pages 99-105.
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Micaela C. Damsten, Barbara M.A. van Vugt-Lussenburg, Tineke Zeldenthuis, Jon S.B. de Vlieger, Jan N.M. Commandeur & Nico P.E. Vermeulen. (2008) Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites. Chemico-Biological Interactions 171:1, pages 96-107.
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Micaela C. Damsten, Jan N. M. Commandeur, Alex Fidder, Albert G. Hulst, Daan Touw, Daan Noort & Nico P. E. Vermeulen. (2007) Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin. Drug Metabolism and Disposition 35:8, pages 1408-1417.
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Marola M.H. van Lipzig, Nico P.E. Vermeulen, Renato Gusinu, Juliette Legler, Heinz Frank, Albrecht Seidel & John H.N. Meerman. (2005) Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity. Environmental Toxicology and Pharmacology 19:1, pages 41-55.
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J.G.M. Bessems, L.L.P. Van Stee, J.N.M. Commandeur, E.J. Groot & N.P.E. Vermeulen. (1997) Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts. Toxicology in Vitro 11:1-2, pages 9-19.
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Huachang Hong, Yuchen Lu, Xiaoyan Zhu, Qiang Wu, Lingmin Jin, Zhigang Jin, Xiaoxuan Wei, Guangcai Ma & Haiying Yu. (2022) Cytotoxicity of Nitrogenous Disinfection Byproducts: A Combined Experimental and Computational Study. SSRN Electronic Journal.
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