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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 7
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Research Article

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation of in vitro metabolism using cDNA-expressed human P450s and human liver microsomes

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Pages 681-693 | Received 29 Nov 1995, Published online: 22 Sep 2008

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A. M. Belliard, B. Baune, M. Fakhfakh, R. Hocquemiller & R. Farinotti. (2003) Determination of the human cytochrome P450s involved in the metabolism of 2n -propylquinoline. Xenobiotica 33:4, pages 341-355.
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A. B. Renwick, D. F. V. Lewis, S. Fulford, D. Surry, B. Williams, P. D. Worboys, X. Cai, R. W. Wang, R. J. Price, B. G. Lake & D. C. Evans. (2001) Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4. Xenobiotica 31:4, pages 187-204.
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S. Furuta, E. Kamada, T. Suzuki, T. Sugimoto, Y. Kawabata, Y. Shinozaki & H. Sano. (2001) Inhibition of drug metabolism in human liver microsomes by nizatidine, cimetidine and omeprazole. Xenobiotica 31:1, pages 1-10.
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M. A. M. WENKER, S. KEŽIĆ, A. C. MONSTER & F. A. DE WOLFF. (2001) Metabolism of styrene in the human liver in vitro: interindividual variation and enantioselectivity. Xenobiotica 31:2, pages 61-72.
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S. Ozawa, K. Ohta, A. Miyajima, H. Kurebayashi, M. Sunouchi, M. Shimizu, N. Murayama, Y. Matsumoto, M. Fukuoka & Y. Ohno. (2000) Metabolic activation of o-phenylphenol to a major cytotoxic metabolite, phenylhydroquinone: role of human CYP1A2 and rat CYP2C11/CYP2E1. Xenobiotica 30:10, pages 1005-1017.
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A. B. Renwick, D. Surry, R. J. Price, B. G. Lake & D. C. Evans. (2000) Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms. Xenobiotica 30:10, pages 955-969.
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J. J. P. Bogaards, M. Bertrand, P. Jackson, M. J. Oudshoorn, R. J. Weaver, P. J. Van Bladeren & B. Walther. (2000) Determining the best animal model for human cytochrome P450 activities: a comparison of mouse, rat, rabbit, dog, micropig, monkey and man. Xenobiotica 30:12, pages 1131-1152.
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SEAN EKINS & STEVEN A. WRIGHTON. (1999) THE ROLE OF CYP2B6 IN HUMAN XENOBIOTIC METABOLISM*. Drug Metabolism Reviews 31:3, pages 719-754.
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T. SHIRAGA, H. KANEKO, K. IWASAKI, Z. TOZUKA, A. SUZUKI & T. HATA. (1999) Identification of cytochrome P450 enzymes involved in the metabolism of zotepine, an antipsychotic drug, in human liver microsomes. Xenobiotica 29:3, pages 217-229.
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M. Nakajima, K. Kobayashi, K. Oshima, N. Shimada, S. Tokudome, K. Chiba & T. Yokoi. (1999) Activation of phenacetin O-deethylase activity by α-naphthoflavone in human liver microsomes. Xenobiotica 29:9, pages 885-898.
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C. CHESNE, C. GUYOMARD, A. GUILLOUZO, J. SCHMID, E. LUDWIG & T. SAUTER. (1998) Metabolism of Meloxicam in human liver involves cytochromes P4502C9 and 3A4. Xenobiotica 28:1, pages 1-13.
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A. B. RENWICK, H. MISTRY, S. E. BALL, D. G. WALTERS, J. KAO & B. G. LAKE. (1998) Metabolism of Zaleplon by human hepatic microsomal cytochrome P450 isoforms. Xenobiotica 28:4, pages 337-348.
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GaryP. Carlson. (1997) EFFECTS OF INDUCERS AND INHIBITORS ON THE MICROSOMAL METABOLISM OF STYRENE TO STYRENE OXIDE IN MICE. Journal of Toxicology and Environmental Health 51:5, pages 477-488.
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S. Onof, T. Hatanaka, S. Miyazawa, M. Tsutsui, T. Aoyama, F. J. Gonzalez & T. Satoh. (1996) Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: Role of CYP2B6, 2C19 and the 3A subfamily. Xenobiotica 26:11, pages 1155-1166.
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