Advanced search
Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 7
Submit an article Journal homepage
63
Views
28
CrossRef citations to date
0
Altmetric
Research Article

A comparative study of precision cut liver slices, hepatocytes, and liver microsomes from the Wistar rat using metronidazole as a model substance

U. G. Sidelmann Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
,
C. Cornett Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
,
J. Tjørnelund Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
&
S. H. Hansen Department of Analytical and Pharmaceutical Chemistry, The Royal Danish School of Pharmacy, Universitetsparken 2, DK-2100, Copenhagen, Denmark
Pages 709-722 | Received 02 Jan 1996, Published online: 22 Sep 2008

Citations (28)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Andrew Campbell, Dirk Holstege, Robert Swezey & Daniel Medina-Cleghorn. (2008) Detoxification of Molinate Sulfoxide: Comparison of Spontaneous and Enzmatic Glutathione Conjugation Using Human and Rat Liver Cytosol. Journal of Toxicology and Environmental Health, Part A 71:19, pages 1338-1347.
Read now

Articles from other publishers (27)

Ziteng Wang, Eric Yu Quan Leow, Hooi Yan Moy & Eric Chun Yong Chan. 2023.
Corinna Fischer, Edgar Leibold & Thomas Göen. (2020) Identification of in vitro phase I metabolites of benzotriazole UV stabilizer UV-327 using HPLC coupled with mass spectrometry. Toxicology in Vitro 68, pages 104932.
Crossref
Morten Sandvik, Christopher O. Miles, Alistair L. Wilkins & Christiane Fæste. (2020) In vitro hepatic biotransformation of the algal toxin pectenotoxin-2. Toxicon: X 6, pages 100031.
Crossref
Shimpei Watanabe, Svante Vikingsson, Anna Åstrand, Volker Auwärter, Henrik Gréen & Robert Kronstrand. (2019) Metabolism of the benzodiazepines norflurazepam, flurazepam, fludiazepam and cinolazepam by human hepatocytes using high-resolution mass spectrometry and distinguishing their intake in authentic urine samples. Forensic Toxicology 38:1, pages 79-94.
Crossref
Xingxing Diao & Marilyn A. Huestis. (2019) New Synthetic Cannabinoids Metabolism and Strategies to Best Identify Optimal Marker Metabolites. Frontiers in Chemistry 7.
Crossref
Surulivelrajan Mallayasamy & Scott R. Penzak. 2018. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions. Drug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions 205 242 .
Liping Cao, Weidong Ding, Rui Jia, Jingliang Du, Tao Wang, Chunyun Zhang, Zhengyan Gu & Guojun Yin. (2017) Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acid on CCl 4 -induced damage in precision-cut liver slices from Jian carp ( Cyprinus carpio var . jian) through inhibition of the nf-kƁ pathway. Fish & Shellfish Immunology 64, pages 234-242.
Crossref
M. Świtała, B. Poźniak, U. Pasławska, T. Grabowski, K. Motykiewicz-Pers & K. Bobrek. (2016) Metronidazole pharmacokinetics during rapid growth in turkeys - relation to changes in haemodynamics and drug metabolism. Journal of Veterinary Pharmacology and Therapeutics 39:4, pages 373-380.
Crossref
Jiangbo Du. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Angela Dudda & Gert Ulrich Kuerzel. 2013. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays 1053 1094 .
Haixia Wu, Linxia Li, Jianzhong Shen, Ying Wang, Kaili Liu & Suxia Zhang. (2012) In vitro metabolism of cyadox in rat, chicken and swine using ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 67-68, pages 175-185.
Crossref
Wei Zhou, Liu-qing Di, Jin-jun Shan, Xiao-lin Bi, Le-tian Chen, Ling-chong Wang & Bao-chang Cai. (2011) In vitro metabolism in Sprague–Dawley rat liver microsomes of forsythoside A in different compositions of Shuang–Huang–Lian. Fitoterapia 82:8, pages 1222-1230.
Crossref
Scott R. Penzak. 2011. Drug Interactions in Infectious Diseases. Drug Interactions in Infectious Diseases 131 165 .
Wan-Chun Li, Kate L. Ralphs & David Tosh. 2010. Mouse Cell Culture. Mouse Cell Culture 185 196 .
Yuet Mei KhongJing ZhangSibo ZhouChristine CheungKai DobersteinVictor SamperHanry Yu. (2007) Novel Intra-Tissue Perfusion System for Culturing Thick Liver Tissue. Tissue Engineering 13:9, pages 2345-2356.
Crossref
Meera Umachandran & Costas Ioannides. (2006) Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72h. Toxicology 224:1-2, pages 14-21.
Crossref
Angela Dudda & Gert Ulrich Kürzel. 2006. Drug Discovery and Evaluation. Drug Discovery and Evaluation 493 520 .
Esther F.A Brandon, Christiaan D Raap, Irma Meijerman, Jos H Beijnen & Jan H.M Schellens. (2003) An update on in vitro test methods in human hepatic drug biotransformation research: pros and cons. Toxicology and Applied Pharmacology 189:3, pages 233-246.
Crossref
K. Rajnarayana, Mada S. Reddy & Devarakonda R. Krishna. (2003) Diosmin pretreatment affects bioavailability of metronidazole. European Journal of Clinical Pharmacology 58:12, pages 803-807.
Crossref
I.A.M de Graaf & H.J Koster. (2003) Cryopreservation of precision-cut tissue slices for application in drug metabolism research. Toxicology in Vitro 17:1, pages 1-17.
Crossref
Takashi Matsubara. (2002) Safety Evaluation and Drug Development based on Biological Fate of Drugs —Efforts Made to Overcome Drug Interaction in Drug Development—. Drug Metabolism and Pharmacokinetics 17:5, pages 379-394.
Crossref
Kateřina Červenková, Marie Belejova, Jaroslav Veselý, Zdeněk Chmela, Miroslav Rypka, Jitka Ulrichová, Martin Modrianský & Patrick Maurel. (2001) CELL SUSPENSIONS, CELL CULTURES, AND TISSUE SLICES - IMPORTANT METABOLIC IN VITRO SYSTEMS. Biomedical Papers 145:2, pages 57-60.
Crossref
Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
Crossref
Elham Hashemi, Clive Till & Costas Ioannides. (2000) Stability of cytochrome P450 proteins in cultured precision-cut rat liver slices. Toxicology 149:2-3, pages 51-61.
Crossref
Sean Ekins, Jukka Maenpää & Steven Wrighton. 1999. Handbook of Drug Metabolism. Handbook of Drug Metabolism 363 399 .
J.P Cravedi, E Perdu-Durand & A Paris. (1998) Cytochrome P450-dependent metabolic pathways and glucuronidation in trout liver slices. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 121:1-3, pages 267-275.
Crossref
K.M.L. Crommentuyn, J.H.M. Schellens, J.D. van den Berg & J.H. Beijnen. (1998) In-vitro metabolism of anti-cancer drugs, methods and applications: paclitaxel, docetaxel, tamoxifen and ifosfamide. Cancer Treatment Reviews 24:5, pages 345-366.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.