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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 7
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Research Article

Quantitation of cytochrome P450 enzymes (CYP1A1/2, 2B11, 2C21 and 3A12) in dog liver microsomes by enzyme-linked immunosorbent assay

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Pages 755-763 | Received 12 Dec 1995, Published online: 22 Sep 2008

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Marilyn N. Martinez, Leposava Antonovic, Michael Court, Mauro Dacasto, Johanna Fink-Gremmels, Butch Kukanich, Chuck Locuson, Katrina Mealey, Michael J. Myers & Lauren Trepanier. (2013) Challenges in exploring the cytochrome P450 system as a source of variation in canine drug pharmacokinetics. Drug Metabolism Reviews 45:2, pages 218-230.
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B. L. Hay Kraus, D. J. Greenblatt, K. Venkatakrishnan & M. H. Court. (2000) Evidence for propofol hydroxylation by cytochrome P4502B11 in canine liver microsomes: breed and gender differences. Xenobiotica 30:6, pages 575-588.
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Y. NISHIBE, M. WAKABAYASHI, T. HARAUCHI & K. OHNO. (1998) Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver. Xenobiotica 28:6, pages 549-557.
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E. TANAKA, C. NARISAWA, H. NAKAMURA, Y. SAWA, H. ETOH, K. TADANO, T. HORIE, H. OHKAWA & S. MISAWA. (1998) Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo. Xenobiotica 28:8, pages 795-802.
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V Simerdova, I Hajek & P Schanilec. (2015) Addisonian crisis in a dog treated with phenobarbitone. Australian Veterinary Journal 93:4, pages 105-108.
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Lone D. Mössner, Andrea Schmitz, Regula Theurillat, Wolfgang Thormann & Meike Mevissen. (2011) Inhibition of cytochrome P450 enzymes involved in ketamine metabolism by use of liver microsomes and specific cytochrome P450 enzymes from horses, dogs, and humans. American Journal of Veterinary Research 72:11, pages 1505-1513.
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Beth Miskimins Mills, Matthew J. Zaya, Rodney R. Walters, Kenneth L. Feenstra, Julie A. White, Jason Gagne & Charles W. Locuson. (2010) Current Cytochrome P450 Phenotyping Methods Applied to Metabolic Drug-Drug Interaction Prediction in Dogs. Drug Metabolism and Disposition 38:3, pages 396-404.
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M. T. BARATTA, M. J. ZAYA, J. A. WHITE & C. W. LOCUSON. (2010) Canine CYP2B11 metabolizes and is inhibited by anesthetic agents often co-administered in dogs. Journal of Veterinary Pharmacology and Therapeutics 33:1, pages 50-55.
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K. Fukunaga, M. Saito, E. Matsuo, M. Muto, K. Mishima, M. Fujiwara & K. Orito. (2009) Long-lasting enhancement of CYP activity after discontinuation of repeated administration of phenobarbital in dogs. Research in Veterinary Science 87:3, pages 455-457.
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Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee & Kenneth L. Feenstra. (2009) Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase . Drug Metabolism and Disposition 37:3, pages 457-461.
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Johanna Fink-Gremmels. (2008) Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences. European Journal of Pharmacology 585:2-3, pages 502-509.
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H. Kamimura. (2006) Genetic polymorphism of cytochrome P450s in beagles: possible influence of CYP1A2 deficiency on toxicological evaluations. Archives of Toxicology 80:11, pages 732-738.
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Magang Shou, Ryan Norcross, Grit Sandig, Ping Lu, Yinghe Li, Yuh Lin, Qin Mei, A. David Rodrigues & Thomas H. Rushmore. (2003) SUBSTRATE SPECIFICITY AND KINETIC PROPERTIES OF SEVEN HETEROLOGOUSLY EXPRESSED DOG CYTOCHROMES P450. Drug Metabolism and Disposition 31:9, pages 1161-1169.
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Moshe Tom, C.R Myers & Michael R Waterman. (2002) Evaluating molar CYP1A level in fish hepatic microsomes by competitive ELISA using recombinant membrane-free CYP1A standard protein. Aquatic Toxicology 59:1-2, pages 101-114.
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T. HOJO, R. OHNO, M. SHIMODA & E. KOKUE. (2002) Enzyme and plasma protein induction by multiple oral administrations of phenobarbital at a therapeutic dosage regimen in dogs. Journal of Veterinary Pharmacology and Therapeutics 25:2, pages 121-127.
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Ryotaro Azuma, Masahito Komuro, Yasuro Kawaguchi, Kazuho Okudaira, Masahiro Hayashi & Hiroshi Kiwada. (2002) Comparative Analysis of In Vitro and In Vivo Pharmacokinetic Parameters Related to Individual Variability of GTS-21 in Canine. Drug Metabolism and Pharmacokinetics 17:1, pages 75-82.
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Takashi Matsubara. (2002) Safety Evaluation and Drug Development based on Biological Fate of Drugs —Efforts Made to Overcome Drug Interaction in Drug Development—. Drug Metabolism and Pharmacokinetics 17:5, pages 379-394.
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D.E Amacher, S.J Schomaker & J.E Burkhardt. (2001) The relationship among microsomal enzyme induction, liver weight and histological change in beagle dog toxicology studies. Food and Chemical Toxicology 39:8, pages 817-825.
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K Walton, J.L Dorne & A.G Renwick. (2001) Uncertainty factors for chemical risk assessment: interspecies differences in the in vivo pharmacokinetics and metabolism of human CYP1A2 substrates. Food and Chemical Toxicology 39:7, pages 667-680.
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Yoshimasa Kyokawa, Yasuhiro Nishibe, Mitsuko Wakabayashi, Toshio Harauchi, Toshiyuki Maruyama, Takahiko Baba & Kouji Ohno. (2001) Induction of intestinal cytochrome P450 (CYP3A) by rifampicin in beagle dogs. Chemico-Biological Interactions 134:3, pages 291-305.
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John E. Snawder & John C. Lipscomb. (2000) Interindividual Variance of Cytochrome P450 Forms in Human Hepatic Microsomes: Correlation of Individual Forms with Xenobiotic Metabolism and Implications in Risk Assessment. Regulatory Toxicology and Pharmacology 32:2, pages 200-209.
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M.Teresa Donato, José V Castell & M.José Gómez-Lechón. (1999) Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models. Journal of Hepatology 31:3, pages 542-549.
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J.R Fry, D Sinclair, C.Holly Piper, S.-L Townsend & N.W Thomas. (1999) Depression of glutathione content, elevation of CYP2E1-dependent activation, and the principal determinant of the fasting-mediated enhancement of 1,3-dichloro-2-propanol hepatotoxicity in the rat. Food and Chemical Toxicology 37:4, pages 351-355.
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