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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 12
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Research Article

Biotransformation and detoxification of insecticidal metyrapone analogues by carbonyl reduction in the human liver

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Pages 1221-1229 | Received 03 Jun 1996, Published online: 22 Sep 2008

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M. Jane Cox Rosemond & John S. Walsh. (2004) Human Carbonyl Reduction Pathways and a Strategy for Their Study In Vitro. Drug Metabolism Reviews 36:2, pages 335-361.
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John F. Kenneke, Christopher S. Mazur, Kristen A. Kellock & Jay P. Overmyer. (2009) Mechanistic Approach to Understanding the Toxicity of the Azole Fungicide Triadimefon to a Nontarget Aquatic Insect and Implications for Exposure Assessment. Environmental Science & Technology 43:14, pages 5507-5513.
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Iván Bélai & Gábor Fekete. (2003) Effects of anti-ecdysteroid quaternary derivatives of azole analogues of metyrapone on the post-embryonic development of the red cotton bug ( Dysdercus cingulatus F) . Pest Management Science 59:4, pages 401-409.
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Gudula Bannenberg, Hans-Jörg Martin, Iván Bélai & Edmund Maser. (2003) 11β-Hydroxysteroid dehydrogenase type 1: tissue-specific expression and reductive metabolism of some anti-insect agent azole analogues of metyrapone. Chemico-Biological Interactions 143-144, pages 449-457.
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Shigeyuki Kitamura, Yoichi Kohno, Yuji Okamoto, Mitsuhiro Takeshita & Shigeru Ohta. (2002) Reductive Metabolism of an α,β-Ketoalkyne, 4-Phenyl-3-Butyn-2-One, by Rat Liver Preparations. Drug Metabolism and Disposition 30:4, pages 414-420.
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Sandra Kong, Ross A McKinnon, Behnaz Mojarrabi & Ieva Stupans. (2002) Absence of type 1 11?-hydroxysteroid dehydrogenase enzyme in koala liver. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 131:1, pages 39-50.
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Edmund Maser, Guangming Xiong, Clemens Grimm, Ralf Ficner & Klaus Reuter. (2001) 3α-Hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional structure and gene regulation. Chemico-Biological Interactions 130-132, pages 707-722.
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Andreas Blum, Hans-Jörg Martin & Edmund Maser. (2000) Human 11β-Hydroxysteroid Dehydrogenase Type 1 Is Enzymatically Active in Its Nonglycosylated Form. Biochemical and Biophysical Research Communications 276:2, pages 428-434.
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Andreas Blum, Hans-J?rg Martin & Edmund Maser. (2000) Human 11?-hydroxysteroid dehydrogenase 1/carbonyl reductase: recombinant expression in the yeast Pichia pastoris and Escherichia coli. Toxicology 144:1-3, pages 113-120.
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Awad Atalla & Edmund Maser. (1999) Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung. Toxicology 139:1-2, pages 155-166.
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Edmund Maser. 1999. Enzymology and Molecular Biology of Carbonyl Metabolism 7. Enzymology and Molecular Biology of Carbonyl Metabolism 7 379 387 .
Udo C.T Oppermann, Gerd Nagel, Ivan Belai, Juliane E Bueld, Susanna Genti-Raimondi, Jan Koolman, Karl J Netter & Edmund Maser. (1998) Carbonyl reduction of an anti-insect agent imidazole analogue of metyrapone in soil bacteria, invertebrate and vertebrate species. Chemico-Biological Interactions 114:3, pages 211-224.
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L. Skálová, Μ. Nobilis, Β. Szotáková, V. Wsol & Ε. Kvasnieková. (1998) Inter-species Comparison of Microsomal Reductive Transformation of Biologically Active Benfluron N-Oxide. Drug Metabolism and Drug Interactions 14:4.
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Edmund Maser & Udo C. T. Oppermann. (2004) The 11β‐Hydroxysteroid Dehydrogenase System, A Determinant of Glucocorticoid and Mineralocorticoid Action. European Journal of Biochemistry 249:2, pages 365-369.
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