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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 11
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Original Article

In vitro and in vivo oxidative biotransformation in the West-African dwarf goat (Caprus hircus aegagrus): Substrate activities and effects of inducers

W. M. Zweers-zeilmaker Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands
,
J. Batzias Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands; Research Institute of Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands
,
R. F. M. Maas Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands
,
G. J. Horbach Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands; Laboratory of Pharmacology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, GR-54006, Thessaloniki, Greece
,
A. S. J. P. A. M. van Miert Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands
&
R. F. Witkamp Faculty of Veterinary Medicine, Department of Veterinary Pharmacology, Pharmacy and Toxicology, Utrecht University, PO Box 80.176, 3508 TD, Utrecht, The Netherlands
Pages 1131-1141 | Received 30 Apr 1996, Published online: 27 Aug 2009

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Kamil Uney, Ilyas Tumer & Bünyamin Traş. (2011) Measurements of caffeine and plasma metabolite/caffeine ratios as a test for hepatic drug-oxidizing capacity in goats. Xenobiotica 41:7, pages 585-592.
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A.S.J.P.A.M. van Miert. (2000) Trends in veterinary clinical and fundamental pharmacology: Past and future in the Netherlands. Veterinary Quarterly 22:1, pages 3-11.
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W. M. ZWEERS-ZEILMAKER, G. J. HORBACH & R. F. WITKAMP*. (1997) Differential inhibitory effects of phenytoin, diclofenac, phenylbutazone and a series of sulfonam ides on hepatic cytochrom e P4502C activity in vitro, and correlation with som e m olecular descriptors in the dwarf goat (Caprus hircus aegagrus).. Xenobiotica 27:8, pages 769-780.
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Tuyen Van Nguyen, Adam Bořík, Jaylen L. Sims, Antonín Kouba, Vladimír Žlábek & Anna Koubová. (2023) Toxicological effects of diclofenac on signal crayfish (Pacifastacus leniusculus) as related to weakly acidic and basic water pH. Aquatic Toxicology 265, pages 106777.
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Johanna Fink-Gremmels. (2008) Implications of hepatic cytochrome P450-related biotransformation processes in veterinary sciences. European Journal of Pharmacology 585:2-3, pages 502-509.
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G. VIRKEL, A. LIFSCHITZ, J. SALLOVITZ, A. PIS & C. LANUSSE. (2006) Assessment of the main metabolism pathways for the flukicidal compound triclabendazole in sheep. Journal of Veterinary Pharmacology and Therapeutics 29:3, pages 213-223.
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Surjyo Jyoti Biswas, Surajit Pathak & Anisur Rahman Khuda-Bukhsh. (2004) Assessment of the genotoxic and cytotoxic potential of an anti-epileptic drug, phenobarbital, in mice: a time course study. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 563:1, pages 1-11.
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H. A. Elsheikh, B. H. Ali, M. Zahurin, A. M. Mustafa, G. Alhadrami & A. K. Bashir. (2002) Comparative Pharmacokinetics of Theophylline in Camels ( Camelus dromedarius ) and Goats ( Caprus hircus ) . Journal of Veterinary Medicine Series A 48:10, pages 581-586.
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Jacques Dupuy, Gilberte Larrieu, Jean Pierre Braun, Michel Alvinerie & Pierre Galtier. (2001) Differential effects of phenobarbital on the constitutive and inducible expression of P450 2B and 3A subfamilies in sheep tissues. Canadian Journal of Physiology and Pharmacology 79:10, pages 848-853.
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A.VAN MIERT. (2001) A Horse is Not a Large Rat: Getting Toxicology into Perspective. The Veterinary Journal 161:3, pages 222-223.
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K JANUS & J ANTOSZEK. (2000) The effect of sex and age on caffeine pharmacokinetics in cattle. Research in Veterinary Science 69:1, pages 33-37.
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A ANADÓN & L REEVE-JOHNSON. (1999) Macrolide antibiotics, drug interactions and microsomal enzymes: implications for veterinary medicine. Research in Veterinary Science 66:3, pages 197-203.
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C. T. Eason, G. R. G. Wright & R. Gooneratne. (1999) Pharmacokinetics of antipyrine, warfarin and paracetamol in the brushtail possum. Journal of Applied Toxicology 19:3, pages 157-161.
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W.M. Zweers‐ZeilmakerG.J. Horbach & R.F. Witkamp. (2002) Effects of non steroidal anti‐inflammatory drugs and sulfonamides on hepatic cytochrome P4502C activity in vitro in goats and cattle . Journal of Veterinary Pharmacology and Therapeutics 21:2, pages 154-157.
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W.M Zweers-Zeilmaker, S Wildschut, R.F Witkamp & A.S.J.P.A.M Van Miert. (1997) The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus). Research in Veterinary Science 63:3, pages 269-272.
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