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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 11
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Original Article

Human liver microsomal diazepam metabolism using cDNA-expressed cytochrome P450s: Role of CYP2B6, 2C19 and the 3A subfamily

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Pages 1155-1166 | Received 14 May 1996, Published online: 27 Aug 2009

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Stanislav Micuda, Lucie Mundlova, Eva Anzenbacherova, Pavel Anzenbacher, Jaroslav Chladek, Leos Fuksa & Jirina Martinkova. (2004) Inhibitory effects of memantine on human cytochrome P450 activities: prediction of in vivo drug interactions. European Journal of Clinical Pharmacology 60:8, pages 583-589.
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Masahiro Hiratsuka, Yudai Hinai, Yumiko Konno, Hisayoshi Nozawa, Shoetsu Konno & Michinao Mizugaki. (2004) Three Novel Single Nucleotide Polymorphisms (SNPs) of the CYP2B6 Gene in Japanese Individuals. Drug Metabolism and Pharmacokinetics 19:2, pages 155-158.
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A Nagashima, E TanakaS Inomata & S Misawa. (2016) A study of the in vitro clinical interaction between lidocaine and premedications using rat liver microsomes. Human & Experimental Toxicology 21:8, pages 453-456.
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Qinmi Wang & James R. Halpert. (2002) Combined Three-Dimensional Quantitative Structure-Activity Relationship Analysis of Cytochrome P450 2B6 Substrates and Protein Homology Modeling. Drug Metabolism and Disposition 30:1, pages 86-95.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (2013) Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models. The Journal of Clinical Pharmacology 41:11, pages 1149-1179.
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Magang Shou, Tin Lu, Kristopher W. Krausz, Yang Sai, Tianjian Yang, Kenneth R. Korzekwa, Frank J. Gonzalez & Harry V. Gelboin. (2000) Use of inhibitory monoclonal antibodies to assess the contribution of cytochromes P450 to human drug metabolism. European Journal of Pharmacology 394:2-3, pages 199-209.
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P.E.B Reilly, S.R Mason & M.A Read. (1999) Human, rat and crocodile liver microsomal monooxygenase activities measured using diazepam and nifedipine: effects of CYP3A inhibitors and relationship to immunochemically detected CYP3A apoprotein. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 122:2, pages 197-204.
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Karthik Venkatakrishnan, Lisa L. von Moltke & David J. Greenblatt. (1998) Relative Quantities of Catalytically Active CYP 2C9 and 2C19 in Human Liver Microsomes: Application of the Relative Activity Factor Approach. Journal of Pharmaceutical Sciences 87:7, pages 845-853.
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JEFFREY A. KLEIN & NORMA KASSARJDIAN. (1997) Lidocaine Toxicity with Tumescent Liposuction. Dermatologic Surgery 23:12, pages 1169-1174.
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