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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 11
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Original Article

Pharmacokinetics of ethylene glycol II. Tissue distribution, dose-dependent elimination, and identification of urinary metabolites following single intravenous, peroral or percutaneous doses in female Sprague-Dawley rats and CD-1® mice*

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Pages 1195-1220 | Received 08 Feb 1996, Published online: 27 Aug 2009

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R. Gomes, R. G. Liteplo & M. E. Meek. (2001) ETHYLENE GLYCOL: HAZARD CHARACTERIZATION AND EXPOSURE–RESPONSE ANALYSIS. Journal of Environmental Science and Health, Part C 19:1, pages 189-217.
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Articles from other publishers (24)

Finis L. Cavendar & Thomas H. Keenan. 2003. Patty's Toxicology. Patty's Toxicology 1 57 .
Szabina A. Stice & Edward W. Carney. 2022. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 803 814 .
Takashi Uebanso, Takaaki Shimohata, Kazuaki Mawatari & Akira Takahashi. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 243 258 .
Takashi Uebanso, Takaaki Shimohata, Kazuaki Mawatari & Akira Takahashi. 2022. Biomarkers in Nutrition. Biomarkers in Nutrition 1 16 .
. 2020. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables. ANSI/AAMI/ISO 10993-16:2017; Biological evaluation of medical devices—Part 16: Toxicokinetic study design for degradation products and leachables.
Takashi Uebanso, Ayumi Yoshimoto, Shinta Aizawa, Maya Nakamura, Rumiko Masuda, Takaaki Shimohata, Kazuaki Mawatari & Akira Takahashi. (2020) Glycolate is a Novel Marker of Vitamin B2 Deficiency Involved in Gut Microbe Metabolism in Mice. Nutrients 12:3, pages 736.
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Jeff Fowles, Marcy Banton, Joanna Klapacz & Hua Shen. (2017) A toxicological review of the ethylene glycol series: Commonalities and differences in toxicity and modes of action. Toxicology Letters 278, pages 66-83.
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Edward W. Carney & Szabina A. Stice. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 797 809 .
Finis L. Cavender. 2003. Patty's Toxicology. Patty's Toxicology 595 640 .
Edward W. Carney. 2011. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 607 615 .
Shakil A. Saghir, Michael J. Bartels & William M. Snellings. (2010) Dermal Penetration of Ethylene Glycol Through Human Skin In Vitro. International Journal of Toxicology 29:3, pages 268-276.
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Yan Li & Kenneth E. McMartin. (2009) Strain differences in urinary factors that promote calcium oxalate crystal formation in the kidneys of ethylene glycol-treated rats. American Journal of Physiology-Renal Physiology 296:5, pages F1080-F1087.
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Edward W. Carney, Belen Tornesi, Daniel A. Markham, Reza J. Rasoulpour & Nigel Moore. (2008) Species‐specificity of ethylene glycol‐induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit. Birth Defects Research Part B: Developmental and Reproductive Toxicology 83:6, pages 573-581.
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Swapna Upadhyay, Joern Carstens, Dominik Klein, Thomas H. Faller, Stephan Halbach, Werner Kirchinger, Winfried Kessler, György A. Csanády & Johannes G. Filser. (2008) Inhalation and epidermal exposure of volunteers to ethylene glycol: Kinetics of absorption, urinary excretion, and metabolism to glycolate and oxalate. Toxicology Letters 178:2, pages 131-141.
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Mike L. Green, Marguerite Hatch & Robert W. Freel. (2005) Ethylene glycol induces hyperoxaluria without metabolic acidosis in rats. American Journal of Physiology-Renal Physiology 289:3, pages F536-F543.
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R. A. Corley, M. J. Bartels, E. W. Carney, K. K. Weitz, J. J. Soelberg, R. A. Gies & K. D. Thrall. (2005) Development of a Physiologically Based Pharmacokinetic Model for Ethylene Glycol and Its Metabolite, Glycolic Acid, in Rats and Humans. Toxicological Sciences 85:1, pages 476-490.
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Robert Hess, Michael J. Bartels & Lynn H. Pottenger. (2004) Ethylene glycol: an estimate of tolerable levels of exposure based on a review of animal and human data. Archives of Toxicology 78:12, pages 671-680.
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Ryuichi Hasegawa, Mutsuko Koizumi & Akihiko Hirose. (2004) Principles of risk assessment for determining the safety of chemicals: Recent assessment of residual solvents in drugs and di(2-ethylhexyl) phthalate. Congenital Anomalies 44:2, pages 51-59.
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. (2004) NTP-CERHR Expert Panel report on the reproductive and developmental toxicity of ethylene glycol. Reproductive Toxicology 18:4, pages 457-532.
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Finis L. Cavender & Edward J. Sowinski. 2003. Patty's Toxicology. Patty's Toxicology.
Saeed R. Khan, Joanne M. Johnson, Ammon B. Peck, Janet G. Cornelius & Patricia A. Glenton. (2002) Expression of Osteopontin in Rat Kidneys: Induction During Ethylene Glycol Induced Calcium Oxalate Nephrolithiasis. Journal of Urology 168:3, pages 1173-1181.
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L. H. Couch & P. C. Howard. (2002) Quantification of glycolic acid in cosmetic products using reversed phase high performance liquid chromatography. International Journal of Cosmetic Science 24:2, pages 89-95.
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Mark J. Graham, Stanley T. Crooke, Kristina M. Lemonidis, Hans J. Gaus, Michael V. Templin & Rosanne M. Crooke. (2001) Hepatic distribution of a phosphorothioate oligodeoxynucleotide within rodents following intravenous administration212Abbreviations: HSV, herpes simplex virus; CGE, capillary gel electrophoresis; and HPLC/ES-MS, high performance liquid chromatography/electrospray-mass spectrometry.1Johnston J, ISIS Pharmaceuticals, personal communication. Cited with permission.. Biochemical Pharmacology 62:3, pages 297-306.
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L. H. Pottenger, E. W. Carney & M. J. Bartels. (2001) Dose-Dependent Nonlinear Pharmacokinetics of Ethylene Glycol Metabolites in Pregnant (GD 10) and Nonpregnant Sprague-Dawley Rats following Oral Administration of Ethylene Glycol. Toxicological Sciences 62:1, pages 10-19.
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