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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 9
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Original Article

Metabolite kinetics of ondansetron in rat. Comparison of hepatic microsomes, isolated hepatocytes and liver slices, with in vivo disposition

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Pages 897-907 | Received 28 Mar 1996, Published online: 27 Aug 2009

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Read on this site (5)

Brian G. Lake & Roger J. Price. (2013) Evaluation of the metabolism and hepatotoxicity of xenobiotics utilizing precision-cut slices. Xenobiotica 43:1, pages 41-53.
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R. De Kanter, M. Monshouwer, A. L. Draaisma, M. H. De Jager, I. A. M. De Graaf, J. H. Proost, D. K. F. Meijer & G. M. M. Groothuis. (2004) Prediction of whole-body metabolic clearance of drugs through the combined use of slices from rat liver, lung, kidney, small intestine and colon. Xenobiotica 34:3, pages 229-241.
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R. De Kanter, M. H. De Jager, A. L. Draaisma, J. U. Jurva, P. Olinga, D. K. F. Meijer & G. M. M. Groothuis. (2002) Drug-metabolizing activity of human and rat liver, lung, kidney and intestine slices. Xenobiotica 32:5, pages 349-362.
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D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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J. Brian Houston & David J. Carlile. (1997) Prediction of Hepatic Clearance from Microsomes, Hepatocytes, and Liver Slices. Drug Metabolism Reviews 29:4, pages 891-922.
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Articles from other publishers (17)

Mingyu Duan, Li Qin, Dafang Zhong & Peng Zhang. (2019) Rapid structure identification of nineteen metabolites of ondansetron in human urine using LC/MS n . Biomedical Chromatography 33:10.
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Mingyu Duan, Li Qin, Dafang Zhong & Peng Zhang. (2018) Identification of novel ondansetron metabolites using LC/MSn and NMR. Journal of Chromatography B 1095, pages 138-141.
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Si H Yang & Myung G Lee. (2008) Effects of cytochrome P450 (CYP) inducers and inhibitors on ondansetron pharmacokinetics in rats: involvement of hepatic CYP2D subfamily and 3A1/2 in ondansetron metabolism. Journal of Pharmacy and Pharmacology 60:7, pages 853-861.
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Urban Fagerholm. (2007) Prediction of human pharmacokinetics—evaluation of methods for prediction of hepatic metabolic clearance. Journal of Pharmacy and Pharmacology 59:6, pages 803-828.
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Masato Chiba, Yasuyuki Ishii & Yuichi Sugiyama. (2009) Prediction of Hepatic Clearance in Human From In Vitro Data for Successful Drug Development. The AAPS Journal 11:2.
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Si H. Yang & Myung G. Lee. (2008) Dose‐independent pharmacokinetics of ondansetron in rats: contribution of hepatic and intestinal first‐pass effects to low bioavailability. Biopharmaceutics & Drug Disposition 29:7, pages 414-426.
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Hayley S. Brown, Anthony Chadwick & J. Brian Houston. (2007) Use of Isolated Hepatocyte Preparations for Cytochrome P450 Inhibition Studies: Comparison with Microsomes for K i Determination . Drug Metabolism and Disposition 35:11, pages 2119-2126.
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H. Axelsson, C. Granhall, E. Floby, Y. Jaksch, M. Svedling & A.-K. Sohlenius-Sternbeck. (2003) Rates of metabolism of chlorzoxazone, dextromethorphan, 7-ethoxycoumarin, imipramine, quinidine, testosterone and verapamil by fresh and cryopreserved rat liver slices, and some comparisons with microsomes. Toxicology in Vitro 17:4, pages 481-488.
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Bert Haenen, Cathy Rompelberg, Klaas van Twillert, Martin Hamzink, Jan Dormans & Jan van Eijkeren. (2002) Utility of Rat Liver Slices to Estimate Hepatic Clearance for Application in Physiologically Based Pharmacokinetic Modeling: A Study with Tolbutamide, a Compound with Low Extraction Efficiency. Drug Metabolism and Disposition 30:3, pages 307-313.
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Gregory L KedderisJohn C Lipscomb. (2016) Application of in vitro biotransformation data and pharmacokinetic modeling to risk assessment. Toxicology and Industrial Health 17:5-10, pages 315-321.
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Carole Lerche-Langrand & Herve J. Toutain. (2000) Precision-cut liver slices: characteristics and use for in vitro pharmaco-toxicology. Toxicology 153:1-3, pages 221-253.
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Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle & Steven A. Wrighton. (2000) Present and future in vitro approaches for drug metabolism. Journal of Pharmacological and Toxicological Methods 44:1, pages 313-324.
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Roger J. Price, Anthony B. Renwick, Paula T. Barton, J. Brian Houston & Brian G. Lake. (2020) Influence of Slice Thickness and Culture Conditions on the Metabolism of 7-Ethoxycoumarin in Precision-cut Rat Liver Slices. Alternatives to Laboratory Animals 26:4, pages 541-548.
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Gregory L. Kedderis. (1997) Extrapolation of in vitro enzyme induction data to humans in vivo. Chemico-Biological Interactions 107:1-2, pages 109-121.
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C.J. Waterfield, J. Delaney, M.D.J. Kerai & J.A. Timbrell. (1997) Correlations between in vivo and in vitro effects of toxic compounds: Studies with hydrazine. Toxicology in Vitro 11:3, pages 217-227.
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P. Olinga, D.K.F. Meijer, M.J.H. Slooff & G.M.M. Groothuis. (1997) Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue. Toxicology in Vitro 12:1, pages 77-100.
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Peter H. Bach, Alison E.M. Vickers, Robyn Fisher, Andreas Baumann, Eva Brittebo, David J. Carlile, Henk J. Koster, Brian G. Lake, Florence Salmon, Thomas W. Sawyer & Greg Skibinski. (2020) The Use of Tissue Slices for Pharmacotoxicology Studies. Alternatives to Laboratory Animals 24:6, pages 893-919.
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