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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 9
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Original Article

Absorption and disposition of ranitidine hydrochloride in rat and dog

P. J. Eddershaw Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
A. P. Chadwick Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
D. M. Higton Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
S. H. Fenwick Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
P. Linacre Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
W. N. Jenner Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
,
J. A. Bell Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
&
G. R. Manchee Bioanalysis and Drug Metabolism Division, Glaxo Wellcome Research and Development, Ware SG12 0DP, UK
 show all
Pages 947-956 | Received 25 Jan 1996, Published online: 27 Aug 2009

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D. M. CROSS & M. K. BAYLISS. (2000) A COMMENTARY ON THE USE OF HEPATOCYTES IN DRUG METABOLISM STUDIES DURING DRUG DISCOVERY AND DEVELOPMENT*. Drug Metabolism Reviews 32:2, pages 219-240.
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Articles from other publishers (13)

Nadia O. Bamfo, Chelsea Hosey-Cojocari, Leslie Z. Benet & Connie M. Remsberg. (2021) Examination of Urinary Excretion of Unchanged Drug in Humans and Preclinical Animal Models: Increasing the Predictability of Poor Metabolism in Humans. Pharmaceutical Research 38:7, pages 1139-1156.
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Emma Eckernäs & Christer Tannergren. (2021) Physiologically Based Biopharmaceutics Modeling of Regional and Colon Absorption in Dogs. Molecular Pharmaceutics 18:4, pages 1699-1710.
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Evence DaureLinda RossCynthia R. L. Webster. (2017) Gastroduodenal Ulceration in Small Animals: Part 2. Proton Pump Inhibitors and Histamine-2 Receptor Antagonists. Journal of the American Animal Hospital Association 53:1, pages 11-23.
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Francisco Afonso-Pereira, Sudaxshina Murdan, Joao Sousa, Francisco Veiga & Abdul W. Basit. (2016) Sex differences in excipient effects: Enhancement in ranitidine bioavailability in the presence of polyethylene glycol in male, but not female, rats. International Journal of Pharmaceutics 506:1-2, pages 237-241.
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Li Di, Karen Atkinson, Christine C. Orozco, Carrie Funk, Hui Zhang, Thomas S. McDonald, Beijing Tan, Jian Lin, Cheng Chang & R. Scott Obach. (2013) In Vitro–In Vivo Correlation for Low-Clearance Compounds Using Hepatocyte Relay Method. Drug Metabolism and Disposition 41:12, pages 2018-2023.
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Juefang Ding. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 3 .
Urban Fagerholm. (2007) Prediction of human pharmacokinetics — renal metabolic and excretion clearance. Journal of Pharmacy and Pharmacology 59:11, pages 1463-1471.
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D. van der MERWE & S. TAWDE. (2009) Antacids in the initial management of metallic zinc ingestion in dogs. Journal of Veterinary Pharmacology and Therapeutics 32:2, pages 203-206.
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E. W. Chung, E. N. M. Ho, D. K. K. Leung, F. P. W. Tang, K. C. H. Yiu & T. S. M. Wan. (2004) Detection of Anti-Ulcer Drugs and Their Metabolites in Horse Urine by Liquid Chromatography ? Mass Spectrometry. Chromatographia 59:S1, pages S29-S38.
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Toshihiro Wajima, Kazuya Fukumura, Yoshitaka Yano & Takayoshi Oguma. (2003) Prediction of Human Pharmacokinetics from Animal Data and Molecular Structural Parameters using Multivariate Regression Analysis: Oral Clearance. Journal of Pharmaceutical Sciences 92:12, pages 2427-2440.
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Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Martin K. Bayliss & David M. Cross. 2000. The Hepatocyte Review. The Hepatocyte Review 365 389 .
Hirohumi Ishikawa, Harunobu Ito, Masahide Higaki, Mika Higaki, Yoshimi Matsumoto, Toshiaki Kamimura, Yousuke Katsura, Tetsuo Tomishi, Yoshikazu Inoue, Hisashi Takasugi, Masaaki Tomoi, Steven Krakowka & Keizo Yoshida. (1999) FR145715, a novel histamine H2 receptor antagonist, with specific anti-Helicobacter pylori activities. European Journal of Pharmacology 378:3, pages 299-310.
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