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Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 10
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Original Article

Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation

L. L. De Zwart Leiden/Amsterdam Center for Drug Research, Division of Molecular Toxicology, Free University, Amsterdam, The Netherlands
,
R. C. A. Hermanns Leiden/Amsterdam Center for Drug Research, Division of Toxicology, University of Leiden, Leiden, The Netherlands
,
J. H. N. Meerman Leiden/Amsterdam Center for Drug Research, Division of Toxicology, University of Leiden, Leiden, The Netherlands
,
J. N. M. Commandeur Leiden/Amsterdam Center for Drug Research, Division of Molecular Toxicology, Free University, Amsterdam, The Netherlands
&
N. P. E. Vermeulen Leiden/Amsterdam Center for Drug Research, Division of Molecular Toxicology, Free University, Amsterdam, The Netherlands
Pages 1087-1100 | Received 17 Apr 1996, Published online: 27 Aug 2009

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F. Guéraud, M. Atalay, N. Bresgen, A. Cipak, P. M. Eckl, L. Huc, I. Jouanin, W. Siems & K. Uchida. (2010) Chemistry and biochemistry of lipid peroxidation products. Free Radical Research 44:10, pages 1098-1124.
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Jon Zárate, Encarnación Goicoechea, Jesús Pascual, Enrique Echevarría & Mariá D. Guillén. (2009) A study of the toxic effect of oxidized sunflower oil containing 4-hydroperoxy-2-nonenal and 4-hydroxy-2-nonenal on cortical TrkA receptor expression in rats. Nutritional Neuroscience 12:6, pages 249-259.
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Articles from other publishers (18)

Barbara M. A. van Vugt-Lussenburg, Liliana Capinha, Jelle Reinen, Martijn Rooseboom, Michel Kranendonk, Rob C. A. Onderwater & Paul Jennings. (2022) “ Commandeuring ” Xenobiotic Metabolism: Advances in Understanding Xenobiotic Metabolism . Chemical Research in Toxicology 35:7, pages 1184-1201.
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Françoise Guéraud. (2017) 4-Hydroxynonenal metabolites and adducts in pre-carcinogenic conditions and cancer. Free Radical Biology and Medicine 111, pages 196-208.
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Roberta Moschini, Eleonora Peroni, Rossella Rotondo, Giovanni Renzone, Dominique Melck, Mario Cappiello, Massimo Srebot, Elio Napolitano, Andrea Motta, Andrea Scaloni, Umberto Mura & Antonella Del-Corso. (2015) NADP+-dependent dehydrogenase activity of carbonyl reductase on glutathionylhydroxynonanal as a new pathway for hydroxynonenal detoxification. Free Radical Biology and Medicine 83, pages 66-76.
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Julia Keller, Maryse Baradat, Isabelle Jouanin, Laurent Debrauwer & Françoise Guéraud. (2015) “Twin peaks”: Searching for 4-hydroxynonenal urinary metabolites after oral administration in rats. Redox Biology 4, pages 136-148.
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Reiko Kiwamoto, Ivonne M. C. M. Rietjens & Ans Punt. (2012) A Physiologically Based in Silico Model for trans -2-Hexenal Detoxification and DNA Adduct Formation in Rat . Chemical Research in Toxicology 25:12, pages 2630-2641.
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Immaculate Amunom, Laura J. Dieter, Viola Tamasi, Jian Cai, Daniel J. Conklin, Sanjay Srivastava, Martha V. Martin, F. Peter Guengerich & Russell A. Prough. (2011) Cytochromes P450 Catalyze the Reduction of α,β-Unsaturated Aldehydes. Chemical Research in Toxicology 24:8, pages 1223-1230.
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Françoise Guéraud. 2010. Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications. Biomarkers for Antioxidant Defense and Oxidative Damage: Principles and Practical Applications 117 135 .
Arnis Kuksis, Gregory Dolnikowski, Jean - Luc Wolfender, Dwight Matthews, Matej Oresic, Bruce German, Claudio Corradini, Nicole Packer & Michael AffolterArnis Kuksis. 2010. Mass Spectrometry and Nutrition Research. Mass Spectrometry and Nutrition Research 102 162 .
Heather C. Kuiper, Cristobal L. Miranda, John D. Sowell & Jan F. Stevens. (2008) Mercapturic Acid Conjugates of 4-Hydroxy-2-nonenal and 4-Oxo-2-nonenal Metabolites Are in Vivo Markers of Oxidative Stress. Journal of Biological Chemistry 283:25, pages 17131-17138.
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Marica Orioli, Giancarlo Aldini, Maria Carmela Benfatto, Roberto Maffei Facino & Marina Carini. (2007) HNE Michael Adducts to Histidine and Histidine-Containing Peptides as Biomarkers of Lipid-Derived Carbonyl Stress in Urines:  LC−MS/MS Profiling in Zucker Obese Rats. Analytical Chemistry 79:23, pages 9174-9184.
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Immaculate Amunom, Laura J. Stephens, Viola Tamasi, Jian Cai, William M. PierceJr.Jr., Daniel J. Conklin, Aruni Bhatnagar, S. Srivastava, Martha V. Martin, F. Peter Guengerich & Russell A. Prough. (2007) Cytochromes P450 catalyze oxidation of α,β-unsaturated aldehydes. Archives of Biochemistry and Biophysics 464:2, pages 187-196.
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Ginger L. Milne, Ling Gao, Alessio Porta, Giuseppe Zanoni, Giovanni Vidari & Jason D. Morrow. (2005) Identification of the Major Urinary Metabolite of the Highly Reactive Cyclopentenone Isoprostane 15-A2t-Isoprostane in Vivo. Journal of Biological Chemistry 280:26, pages 25178-25184.
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FranÇOise Guéraud, Fabienne Crouzet, Jacques Alary, Dinesh Rao, Laurent Debrauwer, FranÇOis Laurent & Jean-Pierre Cravedi. (2005) Enantioselective metabolism of (R)- and (S)-4-hydroxy-2-nonenal in rat. BioFactors 24:1-4, pages 97-104.
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Jacques Alary, Françoise Guéraud & Jean-Pierre Cravedi. (2003) Fate of 4-hydroxynonenal in vivo: disposition and metabolic pathways. Molecular Aspects of Medicine 24:4-5, pages 177-187.
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Arthur J.L. Cooper, Sam A. Bruschi & M.W. Anders. (2002) Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochemical Pharmacology 64:4, pages 553-564.
Crossref
Piet J.M. Boon, H.Susana Marinho, Roelof Oosting & Gerard J. Mulder. (1999) Glutathione Conjugation of 4-Hydroxy-trans-2,3-nonenal in the Rat in Vivo, the Isolated Perfused Liver and Erythrocytes. Toxicology and Applied Pharmacology 159:3, pages 214-223.
Crossref
Yijun Deng & Robert G. Salomon. (1998) Synthesis of [9- 3 H]- trans -4-Hydroxy-2-nonenal . The Journal of Organic Chemistry 63:10, pages 3504-3507.
Crossref
Loeckie L De Zwart, Jennifer Venhorst, Marjolein Groot, Jan N.M Commandeur, Ralph C.A Hermanns, John H.M Meerman, Ben L.M Van Baar & Nico P.E Vermeulen. (1997) Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection. Journal of Chromatography B: Biomedical Sciences and Applications 694:2, pages 277-287.
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