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Research Article

Vernolide-A, a sesquiterpene lactone from Vernonia cinerea, induces apoptosis in B16F-10 melanoma cells by modulating p53 and caspase-3 gene expressions and regulating NF-κB-mediated bcl-2 activation

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Pages 261-270 | Received 22 May 2010, Accepted 24 Aug 2010, Published online: 07 Jun 2011

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Jimsy Johnson & Leyon Varghese. (2023) Tumor Reduction Potentials of Vernonia Cinerea Sesquiterpenes by Induction of Ferroptosis. Journal of Herbs, Spices & Medicinal Plants 29:4, pages 438-451.
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Priyanka Maiti, Mahesha Nand, Tushar Joshi, Muthannan Andavar Ramakrishnan & Subhash Chandra. (2021) Identification of luteolin -7-glucoside and epicatechin gallate from Vernonia cinerea, as novel EGFR L858R kinase inhibitors against lung cancer: Docking and simulation-based study. Journal of Biomolecular Structure and Dynamics 39:14, pages 5048-5057.
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Nittya K. Dogra & Suresh Kumar. (2015) A review on ethno-medicinal uses and pharmacology of Vernonia cinerea Less.. Natural Product Research 29:12, pages 1102-1117.
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D. Divya Theja & S. Nirmala. (2023) A review of Vernonia cinerea L. ethno-medicinal uses and pharmacology shows that it could be a useful plant for medical purposes. Intelligent Pharmacy.
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Narahari N. Palei, S. Navaneetha Krishnan, R. Jayaraman, S. Hemanth Reddy, Anna Balaji, Malay K. Samanta & Bibhash C. Mohanta. (2023) Green Synthesis of Silver Nanoparticles of Vernonia cinerea Leaf Extract and their In vitro Cytotoxicity Activity against Neuroblastoma SHSY-5Y Cell Lines, Antimicrobial and Antioxidant Studies. Recent Patents on Nanotechnology 17:3, pages 270-280.
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Claudio Tabolacci, Daniela De Vita, Antonio Facchiano, Giuseppina Bozzuto, Simone Beninati, Cristina Maria Failla, Marta Di Martile, Carla Lintas, Carlo Mischiati, Annarita Stringaro, Donatella Del Bufalo & Francesco Facchiano. (2023) Phytochemicals as Immunomodulatory Agents in Melanoma. International Journal of Molecular Sciences 24:3, pages 2657.
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Elizabeth Thomas, Vidya Gopalakrishnan, Ranganatha R. Somasagara, Bibha Choudhary & Sathees C. Raghavan. (2016) Extract of Vernonia condensata, Inhibits Tumor Progression and Improves Survival of Tumor-allograft Bearing Mouse. Scientific Reports 6:1.
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Agilan Balupillai, Rajendra N. Prasad, Karthikeyan Ramasamy, Ganesan Muthusamy, Mohana Shanmugham, Kanimozhi Govindasamy & Srithar Gunaseelan. (2015) Caffeic Acid Inhibits UVB-induced Inflammation and Photocarcinogenesis Through Activation of Peroxisome Proliferator-activated Receptor- γ in Mouse Skin . Photochemistry and Photobiology 91:6, pages 1458-1468.
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Poyil Pratheeshkumar, Young-Ok Son, Xin Wang, Sasidharan Padmaja Divya, Binoy Joseph, John Andrew Hitron, Lei Wang, Donghern Kim, Yuanqin Yin, Ram Vinod Roy, Jian Lu, Zhuo Zhang, Yitao Wang & Xianglin Shi. (2014) Cyanidin-3-glucoside inhibits UVB-induced oxidative damage and inflammation by regulating MAP kinase and NF-κB signaling pathways in SKH-1 hairless mice skin. Toxicology and Applied Pharmacology 280:1, pages 127-137.
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Ngeh J. Toyang & Rob Verpoorte. (2013) A review of the medicinal potentials of plants of the genus Vernonia (Asteraceae). Journal of Ethnopharmacology 146:3, pages 681-723.
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Ngeh J. Toyang, Hippolyte K. Wabo, Eugene N. Ateh, Harry Davis, Pierre Tane, Luc B. Sondengam, Joseph Bryant & Rob Verpoorte. (2013) Cytotoxic sesquiterpene lactones from the leaves of Vernonia guineensis Benth. (Asteraceae). Journal of Ethnopharmacology 146:2, pages 552-556.
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Karel Pacak, Marta Sirova, Alessio Giubellino, Lubomira Lencesova, Lucia Csaderova, Marcela Laukova, Sona Hudecova & Olga Krizanova. (2012) NF‐κB inhibition significantly upregulates the norepinephrine transporter system, causes apoptosis in pheochromocytoma cell lines and prevents metastasis in an animal model. International Journal of Cancer 131:10, pages 2445-2455.
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Muhammad Khan, Fei Yi, Azhar Rasul, Ting Li, Nan Wang, Hongwen Gao, Rong Gao & Tonghui Ma. (2012) Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 64:9, pages 783-794.
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