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Research Article

Morphological and biochemical investigation into the possible neuroprotective effects of kolaviron (Garcinia kola bioflavonoid) on the brains of rats exposed to vanadium

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Pages 371-380 | Received 03 Mar 2011, Accepted 04 Oct 2011, Published online: 31 Jan 2012

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Omamuyovwi M. Ijomone, Oritoke M. Aluko, Comfort O. A. Okoh & Azubuike P. Ebokaiwe. (2022) Nω-nitro-L-arginine, a nitric oxide synthase inhibitor, attenuates nickel-induced neurotoxicity. Drug and Chemical Toxicology 45:5, pages 2202-2211.
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Okezie Emmanuel, Miracle E. Uche, Emmanuel D. Dike, Lotanna R. Etumnu, Ositadinma C. Ugbogu & Eziuche A. Ugbogu. (2022) A review on garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities, and toxicology. Biomarkers 27:2, pages 101-117.
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Olumayowa O. Igado, Jan Glaser, Mario Ramos-Tirado, Ezgi Eylül Bankoğlu, Foluso A. Atiba, Ulrike Holzgrabe, Helga Stopper & James O. Olopade. (2018) Isolation of a novel compound (MIMO2) from the methanolic extract of Moringa oleifera leaves: protective effects against vanadium-induced cytotoxity. Drug and Chemical Toxicology 41:3, pages 249-258.
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Jan Tauchen, Adela Frankova, Anna Manourova, Irena Valterova, Bohdan Lojka & Olga Leuner. (2023) Garcinia kola: a critical review on chemistry and pharmacology of an important West African medicinal plant. Phytochemistry Reviews.
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Scholastica O. Anadozie, Olusola B. Adewale, Nicole R.S. Sibuyi, Adewale O. Fadaka, Chinwe C. Isitua, Hajierah Davids & Saartjie Roux. (2023) One-pot synthesis, characterisation and biological activities of gold nanoparticles prepared using aqueous seed extract of Garcinia kola. Process Biochemistry 128, pages 49-57.
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Damilare Rotimi, Jennifer Chidubem Amanze, Adebola Busola Ojo, Matthew Iyobhebhe, Tobiloba Christiana Elebiyo & Oluwafemi Adeleke Ojo. (2022) Kolaviron, A Biflavonoid Compound: Its Pharmacological Activity and Therapeutic Efficacy. Current Bioactive Compounds 18:5.
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Abdalla Ahmed Eldaw Elamin, Omur Gulsum Deniz & Suleyman Kaplan. (2022) The effects of Gum Arabic, curcumin (Curcuma longa) and Garcinia kola on the rat hippocampus after electromagnetic field exposure: A stereological and histological study. Journal of Chemical Neuroanatomy 120, pages 102060.
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Islam M D Alrazi, Tomisin H Ogunwa, Ayodele O Kolawole, Olusola O Elekofehinti, Olaposi I Omotuyi, Takayuki Miyanishi & Shinsaku Maruta. (2021) Kolaflavanone, a biflavonoid derived from medicinal plant Garcinia , is an inhibitor of mitotic kinesin Eg5 . The Journal of Biochemistry 170:5, pages 611-622.
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Ifeoluwa AwogbindinSamuel OnasanwoOluwatoyin EzekielInioluwa AkindoyeniYusuf MustaphaOlatunde Farombi. (2021) Neuroprotection of Kolaviron by Regulation of Nuclear Factor Erythroid 2-related Factor 2 in 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine Mice Model of Parkinson Disease. American Journal of Biopharmacy and Pharmaceutical Sciences 1, pages 5.
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Zemo Gamo Franklin, Amany Digal Ladagu, Ketcha Wanda Germain Jean Magloire, Oluwabusayo Rachael Folarin, Djiogue Sefirin, Taidinda Gilbert Tashara, Njamen Dieudonne & James Olukayode Olopade. (2021) Ameliorative effects of the aqueous extract of Khaya anthotheca (Welw.) C.DC (Meliaceae) in vanadium induced anxiety, memory loss and pathologies in the brain and ovary of mice. Journal of Ethnopharmacology 275, pages 114099.
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Olumayowa O. Igado, Anna Andrioli, Idris A. Azeez, Francesco Girolamo, Mariella Errede, Oluwasanmi O. Aina, Jan Glaser, Ulrike Holzgrabe, Marina Bentivoglio & James O. Olopade. (2020) The ameliorative effects of a phenolic derivative of Moringa oleifera leave against vanadium-induced neurotoxicity in mice. IBRO Reports 9, pages 164-182.
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Ebenezer O. Farombi, Ifeoluwa O. Awogbindin, Precious D. Olorunkalu, Emmanuel Ogbuewu, Bisola F. Oyetunde, Alberta E. Agedah & Philip A. Adeniyi. (2020) Kolaviron protects against nigrostriatal degeneration and gut oxidative damage in a stereotaxic rotenone model of Parkinson’s disease. Psychopharmacology 237:11, pages 3225-3236.
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A. D. Ladagu, F. E. Olopade, O. R. Folarin, T. O. Elufioye, J. V. Wallach, M. B. Dybek, J. O. Olopade & A. Adejare. (2020) Novel NMDA-receptor antagonists ameliorate vanadium neurotoxicity. Naunyn-Schmiedeberg's Archives of Pharmacology 393:9, pages 1729-1738.
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Adeshina O Adekeye, Gold J Irawo & Adedamola Adediran Fafure. (2020) Ficus exasperata Vahl leaves extract attenuates motor deficit in vanadium-induced parkinsonism mice . Anatomy & Cell Biology 53:2, pages 183-193.
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Ebenezer O. Farombi, Ifeoluwa O. Awogbindin, Temitope H. Farombi, Johnson O. Oladele, Edirin R. Izomoh, Oladimeji B. Aladelokun, Ibukunoluwa O. Ezekiel, Oluwabunmi I. Adebambo & Victoria O. Abah. (2019) Neuroprotective role of kolaviron in striatal redo-inflammation associated with rotenone model of Parkinson’s disease. NeuroToxicology 73, pages 132-141.
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Oluwaseun A. Mustapha, Matthew A. Olude, Stephen T. Bello, Ayobami Taiwo, Afusat Jagun & James O. Olopade. (2018) Peripheral axonopathy in sciatic nerve of adult Wistar rats following exposure to vanadium. Journal of the Peripheral Nervous System 24:1, pages 94-99.
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Olamide Elizabeth Adebiyi, Funsho Olakitike Olayemi, James Olukayode Olopade & Ning-Hua Tan. (2019) Βeta-sitosterol enhances motor coordination, attenuates memory loss and demyelination in a vanadium-induced model of experimental neurotoxicity. Pathophysiology 26:1, pages 21-29.
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Afolabi Clement Akinmoladun, Temitope Hannah Farombi & Ebenezer Olatunde Farombi. 2019. Encyclopedia of Food Chemistry. Encyclopedia of Food Chemistry 370 386 .
Isaac A. Adedara, Olatunde Owoeye, Ifeoluwa O. Awogbindin, Babajide O. Ajayi, Joao B.T. Rocha & Ebenezer O. Farombi. (2018) Diphenyl diselenide abrogates brain oxidative injury and neurobehavioural deficits associated with pesticide chlorpyrifos exposure in rats. Chemico-Biological Interactions 296, pages 105-116.
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O. R. Folarin, O. A. Adaramoye, O. O. Akanni & J. O. Olopade. (2017) Changes in the brain antioxidant profile after chronic vanadium administration in mice. Metabolic Brain Disease 33:2, pages 377-385.
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Ademola Adetokunbo Oyagbemi, Temitayo Olutayo Omobowale, James Olukayode Olopade & Ebenezer Olatunde Farombi. (2018) Kolaviron and Garcinia kola attenuate doxorubicin-induced cardiotoxicity in Wistar rats . Journal of Complementary and Integrative Medicine 15:1.
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Afolabi Clement Akinmoladun, Ibrahim Olabayode Saliu, Boyede Dele Olowookere, Olubukola Benedicta Ojo, Mary Tolulope Olaleye, Ebenezer Olatunde Farombi & Afolabi Akintunde Akindahunsi. (2018) Improvement of 2-Vessel Occlusion Cerebral Ischaemia/Reperfusion-Induced Corticostriatal Electrolyte and Redox Imbalance, Lactic Acidosis and Modified Acetylcholinesterase Activity by Kolaviron Correlates with Reduction in Neurobehavioural Deficits. Annals of Neurosciences 25:1, pages 53-62.
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Abhijit Dey. 2017. Neuroprotective Natural Products. Neuroprotective Natural Products 185 246 .
Isaac A. Adedara, Valerie C. Ego, Temitayo I. Subair, Oluwasetemi Oyediran & Ebenezer O. Farombi. (2017) Quercetin Improves Neurobehavioral Performance Through Restoration of Brain Antioxidant Status and Acetylcholinesterase Activity in Manganese-Treated Rats. Neurochemical Research 42:4, pages 1219-1229.
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Mohammed Farahna, Paul F. Seke Etet, Sayed Y. Osman, Kıymet K. Yurt, Naheed Amir, Lorella Vecchio, Isınsu Aydin, Yousef H. Aldebasi, Azimullah Sheikh, John C. Chijuka, Süleyman Kaplan & Abdu Adem. (2017) Garcinia kola aqueous suspension prevents cerebellar neurodegeneration in long-term diabetic rat – a type 1 diabetes mellitus model. Journal of Ethnopharmacology 195, pages 159-165.
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Isaac A. Adedara, Amos O. Abolaji, Umar F. Idris, Bolanle F. Olabiyi, Esther M. Onibiyo, TeminiJesu D. Ojuade & Ebenezer O. Farombi. (2017) Neuroprotective influence of taurine on fluoride-induced biochemical and behavioral deficits in rats. Chemico-Biological Interactions 261, pages 1-10.
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Solomon Umukoro, Oritoke Modupe Aluko, Anthony T. Eduviere & Olatunde Owoeye. (2016) Evaluation of adaptogenic-like property of methyl jasmonate in mice exposed to unpredictable chronic mild stress. Brain Research Bulletin 121, pages 105-114.
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Samuel A. Onasanwo, Ravikanth Velagapudi, Abdelmeneim El-Bakoush & Olumayokun A. Olajide. (2016) Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism. Molecular and Cellular Biochemistry 414:1-2, pages 23-36.
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Olayemi J. Olajide, Bernard U. Enaibe, Oluwamolakun O. Bankole, Oluwole B. Akinola, Babafemi J. Laoye & Olalekan M. Ogundele. (2015) Kolaviron was protective against sodium azide (NaN3) induced oxidative stress in the prefrontal cortex. Metabolic Brain Disease 31:1, pages 25-35.
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Isaac A. Adedara, Olatunde Owoeye, Motunrayo A. Aiyegbusi, Joshua O. Dagunduro, Yetunde M. Daramola & Ebenezer O. Farombi. (2015) Kolaviron protects against benzo[a]pyrene-induced functional alterations along the brain-pituitary-gonadal axis in male rats. Environmental Toxicology and Pharmacology 40:2, pages 459-470.
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Hong Li & Yajia Lan. (2014) Re: Regarding letter by MacGregor and Du concerning “Vanadium exposure-induced neurobehavioral alterations among Chinese workers”. NeuroToxicology 44, pages 367-368.
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Adaramoye Oluwatosin, Akinpelu Tolulope, Kosoko Ayokulehin, Okorie Patricia, Kehinde Aderemi, Falade Catherine & Ademowo Olusegun. (2014) Antimalarial potential of kolaviron, a biflavonoid from Garcinia kola seeds, against Plasmodium berghei infection in Swiss albino mice. Asian Pacific Journal of Tropical Medicine 7:2, pages 97-104.
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