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Research Article

Biological Conversion of N-Phenyl-2-Naphthylamine to 2-Naphthylamine in the Sprague-Dawley Rat

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Pages 295-309 | Published online: 27 Sep 2008

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Jiachang Gong, Timothy Eley, Bing He, Vinod Arora, Thomas Philip, Hao Jiang, John Easter, W. Griffith Humphreys, Ramaswamy A. Iyer & Wenying Li. (2016) Characterization of ADME properties of [14C]asunaprevir (BMS-650032) in humans. Xenobiotica 46:1, pages 52-64.
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Tobias Weiss, Thomas Brüning & Hermann M. Bolt. (2007) Dephenylation of the Rubber Chemical N-Phenyl-2-Naphthylamine to Carcinogenic 2-Naphthylamine: A Classical Problem Revisited. Critical Reviews in Toxicology 37:7, pages 553-566.
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Articles from other publishers (6)

Raman Sharma, Matthew S. Dowling, Kentaro Futatsugi & Amit S. Kalgutkar. (2023) Mitigating a Bioactivation Liability with an Azetidine-Based Inhibitor of Diacylglycerol Acyltransferase 2 (DGAT2) En Route to the Discovery of the Clinical Candidate Ervogastat. Chemical Research in Toxicology 36:6, pages 934-946.
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Kentaro Futatsugi, Shawn Cabral, Daniel W. Kung, Kim Huard, Esther Lee, Markus Boehm, Jonathan Bauman, Ronald W. Clark, Steven B. Coffey, Collin Crowley, Anne-Marie Dechert-Schmitt, Matthew S. Dowling, Robert Dullea, James R. Gosset, Amit S. Kalgutkar, Kou Kou, Qifang Li, Yajing Lian, Paula M. Loria, Allyn T. Londregan, Mark Niosi, Christine Orozco, John C. Pettersen, Jeffrey A. Pfefferkorn, Jana Polivkova, Trenton T. Ross, Raman Sharma, Ingrid A. Stock, Gregory Tesz, Hanna Wisniewska, Bryan Goodwin & David A. Price. (2022) Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis. Journal of Medicinal Chemistry 65:22, pages 15000-15013.
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Kitmin Chen, Alexander S. Edgar, Camille H. Wong & Dali Yang. (2022) Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry: A Strategy for Optimization, Characterization, and Quantification of Antioxidant Nitro Derivatives. ACS Omega 7:36, pages 32701-32707.
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Eike Maximilian Marek, Stephan Koslitz, Tobias Weiss, Manigé Fartasch, Gerhard Schlüter, Heiko Udo Käfferlein & Thomas Brüning. (2017) Quantification of N-phenyl-2-naphthylamine by gas chromatography and isotope-dilution mass spectrometry and its percutaneous absorption ex vivo under workplace conditions. Archives of Toxicology 91:11, pages 3587-3596.
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Tobias Weiss, Hermann M. Bolt, Gerhard Schlüter, Stephan Koslitz, Dirk Taeger, Peter Welge & Thomas Brüning. (2013) Metabolic dephenylation of the rubber antioxidant N-phenyl-2-naphthylamine to carcinogenic 2-naphthylamine in rats. Archives of Toxicology 87:7, pages 1265-1272.
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Souheil Laham & Marc Potvin. (1984) Comparative N-dephenylation of N-phenyl-2-naphthylamine in Sprague-Dawley rats and New Zealand White rabbits. Chemosphere 13:5-6, pages 657-667.
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