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Drug and Chemical Toxicology Volume 17, 1994 - Issue 1
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Research Article

Efficacy Comparison of Scopolamine (SCP) and Diazepam (DZ) Against Soman-Induced Lethality in Guinea Pigs

L. W. Harris U.S. Army MRICD, Aberdeen Proving Ground, MD, 21010
,
C. Gainings Medical College of Virginia, Richmond, VA
,
W. H. Carter Medical College of Virginia, Richmond, VA
,
D. R. Anderson U.S. Army MRICD, Aberdeen Proving Ground, MD, 21010
,
W. J. Lennox U.S. Army MRICD, Aberdeen Proving Ground, MD, 21010
,
S. L. Bowersox U.S. Army MRICD, Aberdeen Proving Ground, MD, 21010
&
R. P. Solana U.S. Army MRICD, Aberdeen Proving Ground, MD, 21010
 show all
Pages 35-50 | Published online: 27 Sep 2008

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Tsung-Ming Shih, Jeffrey A. Koenig & Cindy Acon Chen. (2019) Comparative effects of scopolamine and phencynonate on organophosphorus nerve agent-induced seizure activity, neuropathology and lethality. Toxicology Mechanisms and Methods 29:5, pages 322-333.
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Magnus M. Che, Soma Chanda, Jian Song, Bhupendra P. Doctor, Peter E. Rezk, Praveena Sabnekar, Michael W. Perkins, Alfred M. Sciuto & Madhusoodana P. Nambiar. (2011) Aerosolized scopolamine protects against microinstillation inhalation toxicity to sarin in guinea pigs. Toxicology Mechanisms and Methods 21:6, pages 463-472.
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Iris Kventsel, Matitiahu Berkovitch, Ahuva Reiss, Mordechai Bulkowstein & Eran Kozer. (2005) Scopolamine Treatment for Severe Extra-Pyramidal Signs Following Organophosphate (Chlorpyrifos) Ingestion. Clinical Toxicology 43:7, pages 877-879.
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Dana R. Anderson, Larrel W. Harris, Fat-Chun T. Chang, Wallace B. Baze, Benedict R. Capacio, Susan L. Byers & Willard J. Lennox. (1997) Antagonism of Soman-Induced Convulsions by Midazolam, Diazepam and Scopolamine. Drug and Chemical Toxicology 20:3, pages 115-131.
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Articles from other publishers (10)

E. Wigenstam, E. Forsberg, A. Bucht & L. Thors. (2021) Efficacy of atropine and scopolamine on airway contractions following exposure to the nerve agent VX. Toxicology and Applied Pharmacology 419, pages 115512.
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Reuben S. Maghembe, Andrew G. Mtewa & Jonathan T. Bvunzawabaya. 2021. Phytochemistry, the Military and Health. Phytochemistry, the Military and Health 69 118 .
Cecelia Jackson, Cherish Ardinger, Kristin M. Winter, John H. McDonough & Hilary S. McCarren. (2019) Validating a model of benzodiazepine refractory nerve agent-induced status epilepticus by evaluating the anticonvulsant and neuroprotective effects of scopolamine, memantine, and phenobarbital. Journal of Pharmacological and Toxicological Methods 97, pages 1-12.
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Marcio de Araujo Furtado, Franco Rossetti, Soma Chanda & Debra Yourick. (2012) Exposure to nerve agents: From status epilepticus to neuroinflammation, brain damage, neurogenesis and epilepsy. NeuroToxicology 33:6, pages 1476-1490.
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Michael W. Perkins, Zdenka Pierre, Peter Rezk, Jian Song, Samuel Oguntayo, Venee Morthole, Alfred M. Sciuto, Bhupendra P. Doctor & Madhusoodana P. Nambiar. (2011) Protective Effects of Aerosolized Scopolamine Against Soman-Induced Acute Respiratory Toxicity in Guinea Pigs. International Journal of Toxicology 30:6, pages 639-649.
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Yong-An Wang, Wen-Xia Zhou, Jiang-xiong Li, Yan-Qin Liu, Yong-Juan Yue, Jian-Quan Zheng, Ke-Liang Liu & Jin-Xiu Ruan. (2005) Anticonvulsant effects of phencynonate hydrochloride and other anticholinergic drugs in soman poisoning: Neurochemical mechanisms. Life Sciences 78:2, pages 210-223.
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Sebastien J. Wood & John E. H. Tattersall. (2001) An improved brain slice model of nerve agent-induced seizure activity. Journal of Applied Toxicology 21:S1, pages S83-S86.
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John H. McDonoughJr.Jr., L.Dean Zoeffel, Joseph McMonagle, Tracy L. Copeland, C.Dahlem Smith & Tsung-Ming Shih. (1999) Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs. Epilepsy Research 38:1, pages 1-14.
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Tsung-Ming Shih, John H. McDonoughJr.Jr. & Irwin Koplovitz. (1999) Anticonvulsants for soman-induced seizure activity. Journal of Biomedical Science 6:2, pages 86-96.
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JOHN H McDONOUGHJR.JR. & TSUNG-MING SHIH. (1997) Neuropharmacological Mechanisms of Nerve Agent-induced Seizure and Neuropathology 1 1The animals used in studies performed in, or sponsored by, this Institute were handled in accordance with the principles stated in the Guide for the Care and Use of Laboratory Animals, proposed by the Committee on Care and Use of Laboratory Animals of the Institute of Laboratory Animal Resources, National Research Council, DHHA, National Institute of Health Publication #85–23, 1985, and the Animal Welfare Act of 1966, as amended. The opinions, or assertions contained herein are the private views of the authors, and are not to be construed as reflecting the views of the Department of the Army or the Department of Defense.. Neuroscience & Biobehavioral Reviews 21:5, pages 559-579.
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