Citations (70)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (2)
Jennifer Christine Gutierrez & Kathleen Hwang. (2017) The toxicity of methotrexate in male fertility and paternal teratogenicity. Expert Opinion on Drug Metabolism & Toxicology 13:1, pages 51-58.
Read now
Read now
Sumona Saha & Arnold Wald. (2012) Safety and efficacy of immunomodulators and biologics during pregnancy and lactation for the treatment of inflammatory bowel disease. Expert Opinion on Drug Safety 11:6, pages 947-957.
Read now
Read now
Articles from other publishers (68)
Abdullah Alhamam, Laurianne Rita Garabed, Sania Julian & Ryan Flannigan. (2023) The association of medications and supplements with human male reproductive health: a systematic review. Fertility and Sterility 120:6, pages 1112-1137.
Crossref
Crossref
Peter Zarén, Carl Turesson & Aleksander Giwercman. (2023) Methotrexate use among men—association with fertility and the perinatal health of their children: a Swedish nationwide register study. Fertility and Sterility 120:3, pages 661-669.
Crossref
Crossref
John Gubatan, Grant E. Barber, Ole Haagen Nielsen, Carsten Bogh Juhl, Cynthia Maxwell, Michael L. Eisenberg & Sarah E. Streett. (2023) Paternal Medications in Inflammatory Bowel Disease and Male Fertility and Reproductive Outcomes: A Systematic Review and Meta-analysis. Clinical Gastroenterology and Hepatology 21:9, pages 2222-2238.
Crossref
Crossref
Raluca Roxana Grigorescu, Ioana Alexandra Husar-Sburlan, Georgiana Rosulescu, Anca Bobirca, Razvan Cerban, Florin Bobirca & Madalina Marieta Florescu. (2023) Pregnancy in Patients with Inflammatory Bowel Diseases—A Literature Review. Life 13:2, pages 475.
Crossref
Crossref
Soumaya Boussaid, Yasmine Makhlouf, Sonia Rekik, Samia Jammali, Elhem Cheour, Hela Sahli, Mohamed Elleuch & Helmi Ben Saad. (2022) The effects of autoimmune rheumatic-related diseases on male reproductive health: A systematic review. Journal of Reproductive Immunology 150, pages 103472.
Crossref
Crossref
Charles Stephen Foster & Marisa Walsh. 2022. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology
7045
7071
.
Sara CACCIAPUOTI, Emanuele SCALA, Matteo MEGNA, Lucia GALLO, Giuseppina FONTANELLA, Angelo RUGGIERO, Silvia SAVASTANO & Gabriella FABBROCINI. (2021) Impact of current antipsoriatic systemic treatments on male and female fertility: what endocrinologists need to know. Minerva Endocrinology 46:3.
Crossref
Crossref
Nicolai B. Jensen, Signe D. Justesen, Agnete Larsen, Erik Ernst & Lars H. Pedersen. (2021) A systematic overview of the spermatotoxic and genotoxic effects of methotrexate, ganciclovir and mycophenolate mofetil. Acta Obstetricia et Gynecologica Scandinavica 100:9, pages 1557-1580.
Crossref
Crossref
Renata Finelli, Kristian Leisegang, Federica Finocchi, Salvatore De Masi, Ashok Agarwal & Giovanni Damiani. (2021) The impact of autoimmune systemic inflammation and associated medications on male reproductive health in patients with chronic rheumatological, dermatological, and gastroenterological diseases: A systematic review. American Journal of Reproductive Immunology 85:5.
Crossref
Crossref
Rena H Cao & Michael C Grimm. (2020) Pregnancy and medications in inflammatory bowel disease. Obstetric Medicine 14:1, pages 4-11.
Crossref
Crossref
I. Belinchón, M. Velasco, M. Ara-Martín, S. Armesto Alonso, O. Baniandrés Rodríguez, L. Ferrándiz Pulido, M. García-Bustinduy, J.A. Martínez-López, N. Martínez Sánchez, A. Pérez Ferriols, E. Pérez Pascual, R. Rivera Díaz, R. Ruiz-Villaverde, R. Taberner Ferrer, A. Vicente Villa & J.M. Carrascosa. (2021) Management of Psoriasis During Preconception, Pregnancy, Postpartum, and Breastfeeding: A Consensus Statement. Actas Dermo-Sifiliográficas (English Edition) 112:3, pages 225-241.
Crossref
Crossref
I. Belinchón, M. Velasco, M. Ara-Martín, S. Armesto Alonso, O. Baniandrés Rodríguez, L. Ferrándiz Pulido, M. García-Bustinduy, J.A. Martínez-López, N. Martínez Sánchez, A. Pérez Ferriols, E. Pérez Pascual, R. Rivera Díaz, R. Ruiz-Villaverde, R. Taberner Ferrer, A. Vicente Villa & J.M. Carrascosa. (2021) Consenso sobre las actuaciones a seguir durante la edad fértil, el embarazo, el posparto y la lactancia en pacientes con psoriasis. Actas Dermo-Sifiliográficas 112:3, pages 225-241.
Crossref
Crossref
A. Nast, C. Smith, P.I. Spuls, G. Avila Valle, Z. Bata‐Csörgö, H. Boonen, E. De Jong, I. Garcia‐Doval, P. Gisondi, D. Kaur‐Knudsen, S. Mahil, T. Mälkönen, J.T. Maul, S. MburuU. Mrowietz, K. Reich, E. Remenyik, K.M. Rønholt, P.G. Sator, M. Schmitt‐Egenolf, M. Sikora, K. Strömer, O. Sundnes, D. TrigosG. Van Der Kraaij, N. Yawalkar & C. Dressler. (2021) EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris – Part 2: specific clinical and comorbid situations. Journal of the European Academy of Dermatology and Venereology 35:2, pages 281-317.
Crossref
Crossref
C. Stephen Foster & Marisa Walsh. 2020. Albert and Jakobiec's Principles and Practice of Ophthalmology. Albert and Jakobiec's Principles and Practice of Ophthalmology
1
27
.
Benjamin Yu, Anne L. Darves-Bornoz, Robert E. Brannigan & Joshua A. Halpern. (2020) Acute anejaculation, hypogonadism, and fertility preservation in the setting of neurosarcoidosis: case report and literature review. F&S Reports 1:3, pages 317-325.
Crossref
Crossref
L F Perez-Garcia, R J E M Dolhain, S Vorstenbosch, W Bramer, E van Puijenbroek, J M W Hazes & B te Winkel. (2020) The effect of paternal exposure to immunosuppressive drugs on sexual function, reproductive hormones, fertility, pregnancy and offspring outcomes: a systematic review. Human Reproduction Update 26:6, pages 961-1001.
Crossref
Crossref
Alan Menter, Joel M. Gelfand, Cody Connor, April W. Armstrong, Kelly M. Cordoro, Dawn M.R. Davis, Boni E. Elewski, Kenneth B. Gordon, Alice B. Gottlieb, Daniel H. Kaplan, Arthur Kavanaugh, Matthew Kiselica, Dario Kivelevitch, Neil J. Korman, Daniela Kroshinsky, Mark Lebwohl, Craig L. Leonardi, Jason Lichten, Henry W. Lim, Nehal N. Mehta, Amy S. Paller, Sylvia L. Parra, Arun L. Pathy, Elizabeth Farley Prater, Robert S. Rahimi, Reena N. Rupani, Michael Siegel, Benjamin Stoff, Bruce E. Strober, Elliot B. Tapper, Emily B. Wong, Jashin J. Wu, Vidhya Hariharan & Craig A. Elmets. (2020) Joint American Academy of Dermatology–National Psoriasis Foundation guidelines of care for the management of psoriasis with systemic nonbiologic therapies. Journal of the American Academy of Dermatology 82:6, pages 1445-1486.
Crossref
Crossref
Bonnie L. Bermas. (2020) Paternal safety of anti-rheumatic medications. Best Practice & Research Clinical Obstetrics & Gynaecology 64, pages 77-84.
Crossref
Crossref
Yong Eun Park & Tae Oh Kim. (2020) Sexual Dysfunction and Fertility Problems in Men with Inflammatory Bowel Disease. The World Journal of Men's Health 38:3, pages 285.
Crossref
Crossref
Maria Mouyis, Julia D. Flint & Ian P. Giles. (2019) Safety of anti-rheumatic drugs in men trying to conceive: A systematic review and analysis of published evidence. Seminars in Arthritis and Rheumatism 48:5, pages 911-920.
Crossref
Crossref
M.C. Micu, M. Ostensen, P.M. Villiger, R. Micu & R. Ionescu. (2018) Paternal exposure to antirheumatic drugs—What physicians should know: Review of the literature. Seminars in Arthritis and Rheumatism 48:2, pages 343-355.
Crossref
Crossref
Dana Ley, Jeffrey Jones, John Parrish, Sana Salih, Freddy Caldera, Edna Tirado, Benjamin Leader & Sumona Saha. (2018) Methotrexate Reduces DNA Integrity in Sperm From Men With Inflammatory Bowel Disease. Gastroenterology 154:8, pages 2064-2067.e3.
Crossref
Crossref
Mariangela Allocca, Daniela Gilardi, Gionata Fiorino, Federica Furfaro, Laurent Peyrin-Biroulet & Silvio Danese. (2018) Sexual and reproductive issues and inflammatory bowel disease. European Journal of Gastroenterology & Hepatology 30:3, pages 316-322.
Crossref
Crossref
Piyush Kumar, Anupam Das, NiharikaRanjan Lal, Sourabh Jain & Anupama Ghosh. (2018) Safety of important dermatological drugs (retinoids, immune suppressants, anti androgens and thalidomide) in reproductively active males with respect to pregnancy outcome: A brief review of literature. Indian Journal of Dermatology, Venereology and Leprology 84:5, pages 539.
Crossref
Crossref
Rachel W. Winter, Michael Due Larsen, Bjarne Magnussen, Sonia Friedman, Heidi Kammerlander & Bente Mertz Nørgård. (2017) Birth outcomes after preconception paternal exposure to methotrexate: A nationwide cohort study. Reproductive Toxicology 74, pages 219-223.
Crossref
Crossref
Luke Martin, Sheala Mullaney, William Peche, Kathryn Peterson, Stephanie Chan, Ryan Morton, Yuan Wan, Chong Zhang, Angela P. Presson, Benjamin Emery, Kenneth Aston, Timothy Jenkins, Douglas Carrell & James Hotaling. (2017) Population-based Semen Analysis Results and Fertility Among Patients With Inflammatory Bowel Disease: Results From Subfertility Health Assisted Reproduction and the Environment (SHARE) Study. Urology 107, pages 114-119.
Crossref
Crossref
Jill K.J. Gaidos & Sunanda V. Kane. (2017) Sexuality, Fertility, and Pregnancy in Crohn's Disease. Gastroenterology Clinics of North America 46:3, pages 531-546.
Crossref
Crossref
Omid Zahedi Niaki, Sasha Bernatsky & Evelyne Vinet. (2017) Reproductive Issues in Males with SLE. Current Treatment Options in Rheumatology 3:3, pages 173-180.
Crossref
Crossref
Monika Østensen. (2017) Sexual and reproductive health in rheumatic disease. Nature Reviews Rheumatology 13:8, pages 485-493.
Crossref
Crossref
Anne Grosen, Jens Kelsen, Christian Lodberg Hvas, Emanuelle Bellaguarda & Stephen B. Hanauer. (2017) The Influence of Methotrexate Treatment on Male Fertility and Pregnancy Outcome After Paternal Exposure. Inflammatory Bowel Diseases 23:4, pages 561-569.
Crossref
Crossref
Krishna Prahlad Maremanda & G.B. Jena. (2017) Methotrexate-induced germ cell toxicity and the important role of zinc and SOD1: Investigation of molecular mechanisms. Biochemical and Biophysical Research Communications 483:1, pages 596-601.
Crossref
Crossref
Erma Z. Drobnis & Ajay K. NangiaErma Z. Drobnis & Ajay K. Nangia. 2017. Impacts of Medications on Male Fertility. Impacts of Medications on Male Fertility
179
210
.
Takeshi Shin & Hiroshi Okada. (2016) Infertility in men with inflammatory bowel disease. World Journal of Gastrointestinal Pharmacology and Therapeutics 7:3, pages 361.
Crossref
Crossref
Elena Pentsova & Andrew B. Lassman. 2013. Fertility Preservation in Male Cancer Patients. Fertility Preservation in Male Cancer Patients
150
160
.
. 2013. Fertility Preservation in Male Cancer Patients. Fertility Preservation in Male Cancer Patients
104
171
.
Kubilay Inci & Levent Mert Gunay. 2012. Male Infertility. Male Infertility
297
306
.
Kristine Busse & John Koo. (2018) A Practical Approach to the Use of Methotrexate. Psoriasis Forum 16a:3, pages 48-59.
Crossref
Crossref
Marcus Martineau, Dorian O Haskard & Catherine Nelson-Piercy. (2010) Behçet's syndrome in pregnancy. Obstetric Medicine 3:1, pages 2-7.
Crossref
Crossref
Alan Menter, Neil J. Korman, Craig A. Elmets, Steven R. Feldman, Joel M. Gelfand, Kenneth B. Gordon, Alice B. Gottlieb, John Y.M. Koo, Mark Lebwohl, Henry W. Lim, Abby S. Van Voorhees, Karl R. Beutner & Reva Bhushan. (2009) Guidelines of care for the management of psoriasis and psoriatic arthritis. Journal of the American Academy of Dermatology 61:3, pages 451-485.
Crossref
Crossref
Robert E. Kalb, Bruce Strober, Gerald Weinstein & Mark Lebwohl. (2009) Methotrexate and psoriasis: 2009 National Psoriasis Foundation Consensus Conference. Journal of the American Academy of Dermatology 60:5, pages 824-837.
Crossref
Crossref
Linda A. Feagins & Sunanda V. Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. American Journal of Gastroenterology 104:3, pages 768-773.
Crossref
Crossref
Linda A Feagins & Sunanda V Kane. (2009) Sexual and Reproductive Issues for Men With Inflammatory Bowel Disease. The American Journal of Gastroenterology 104:3, pages 768-773.
Crossref
Crossref
C. Stephen Foster, Sumru Onal & Joan M. O'Brien. 2008. Albert & Jakobiec's Principles & Practice of Ophthalmology. Albert & Jakobiec's Principles & Practice of Ophthalmology
4401
4416
.
Leah R. Griggs & David A. Schwartz. (2006) Successful Paternity of a Healthy Child While Taking Methotrexate for Crohn's Disease. The American Journal of Gastroenterology 101:12, pages 2893-2894.
Crossref
Crossref
Katherine K. Temprano, Rama Bandlamudi & Terry L. Moore. (2005) Antirheumatic Drugs in Pregnancy and Lactation. Seminars in Arthritis and Rheumatism 35:2, pages 112-121.
Crossref
Crossref
H. Zachariae. 2003. Textbook of Psoriasis. Textbook of Psoriasis
208
246
.
Carol A. Wallace. (1998) The use of methotrexate in childhood rheumatic diseases. Arthritis & Rheumatism 41:3, pages 381-391.
Crossref
Crossref
Gary S. Hoffman. (2005) Treatment of wegener's granulomatosis: Time to change the standard of care?. Arthritis & Rheumatism 40:12, pages 2099-2104.
Crossref
Crossref
Samireh Said, Edward W.B. Jeffes & Gerald D. Weinstein. (1997) Methotrexate. Clinics in Dermatology 15:5, pages 781-797.
Crossref
Crossref
Lawrence H Brent, David A Beckman & Robert L Brent. (1997) The effects of antirheumatic drugs on reproductive function. Reproductive Toxicology 11:4, pages 561-577.
Crossref
Crossref
Henk van den Berg, Nelia E. Langeveld, Cees H. N. Veenhof & Henk Behrendt. (1997) Treatment of isolated testicular recurrence of acute lymphoblastic leukemia without radiotherapy. Cancer 79:11, pages 2257-2262.
Crossref
Crossref
Kristi L. Lenz & Amy W. Valley. (2016) Review : Infertility after chemotherapy: A review of the risks and strategies for prevention. Journal of Oncology Pharmacy Practice 2:2, pages 75-100.
Crossref
Crossref
Edward W.B. JeffesIIIIII & Gerald D. Weinstein. (1995) Methotrexate and Other Chemotherapeutic Agents Used to Treat Psoriasis. Dermatologic Clinics 13:4, pages 875-890.
Crossref
Crossref
David J. Handelsman. (1994) Testicular Dysfunction in Systemic Disease. Endocrinology and Metabolism Clinics of North America 23:4, pages 839-856.
Crossref
Crossref
Laura F. Morris, Mary J. Harrod, M. Alan Menter & Alan K. Silverman. (1993) Methotrexate and reproduction in men: Case report and recommendations. Journal of the American Academy of Dermatology 29:5, pages 913-916.
Crossref
Crossref
Jenny A. Crittenden, David J. Handelsman & Graeme J. Stewart. (1992) Semen analysis in human immunodeficiency virus infection. Fertility and Sterility 57:6, pages 1294-1299.
Crossref
Crossref
Christopher J. Scully, Cynthia J. Anderson & Grant W. Cannon. (1991) Long-term methotrexate therapy for rheumatoid arthritis. Seminars in Arthritis and Rheumatism 20:5, pages 317-331.
Crossref
Crossref
Carol A. Wallace, W. Archie Bleyer, David D. Sherry, Kathy L. Salmonson & Ralph J. Wedgwood. (2005) Toxicity and serum levels of methotrexate in children with juvenile rheumatoid arthritis. Arthritis & Rheumatism 32:6, pages 677-681.
Crossref
Crossref
James R. Davidson, Frank M. Graziano & Ralph J. Rothenberg. (2005) Methotrexate therapy for severe systemic lupus erythematosus. Arthritis & Rheumatism 30:10, pages 1195-1196.
Crossref
Crossref
Donald R. Miller, Peter W. Letendre, Douglas J. DeJong & Justus J. Fiechtner. (2012) Methotrexate in Rheumatoid Arthritis: An Update. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 6:4, pages 170-178.
Crossref
Crossref
Edward E. Wallach, Marian D. Damewood & Louise B. Grochow. (1986) Prospects for Fertility after Chemotherapy or Radiation for Neoplastic Disease. Fertility and Sterility 45:4, pages 443-459.
Crossref
Crossref
Peter W. Letendre, Douglas J. DeJong & Donald R. Miller. (2017) The Use of Methotrexate in Rheumatoid Arthritis. Drug Intelligence & Clinical Pharmacy 19:5, pages 349-358.
Crossref
Crossref
Nicholas Christophidis. (1984) Methotrexate. Clinics in Rheumatic Diseases 10:2, pages 401-415.
Crossref
Crossref
Robert F. Willkens. (1983) Reappraisal of the use of methotrexate in rheumatic disease. The American Journal of Medicine 75:4, pages 19-25.
Crossref
Crossref
Ramona M. Chapman. (1983) Gonadal injury resulting from chemotherapy. American Journal of Industrial Medicine 4:1, pages 149-161.
Crossref
Crossref
Ramona M. Chapman. (1983) Gonadal Injury Resulting From Chemotherapy. American Journal of Industrial Medicine 4:1-2, pages 149-161.
Crossref
Crossref
Henry H. RoenigkJr.Jr., Robert Auerbach, Howard I. Maibach & Gerald D. Weinstein. (1982) Methotrexate guidelines—revised. Journal of the American Academy of Dermatology 6:2, pages 145-155.
Crossref
Crossref
D. J. HANDELSMAN, V. L. RALEC, D. J. TILLER, J. S. HORVATH & J. R. TURTLE. (2008) TESTICULAR FUNCTION AFTER RENAL TRANSPLANTATION. Clinical Endocrinology 14:5, pages 527-538.
Crossref
Crossref