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Archives of Andrology
Journal of Reproductive Systems
Volume 24, 1990 - Issue 2
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Original Article

Interaction Between Prostasomes and Spermatozoa From Human Semen

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Pages 147-157 | Received 01 Sep 1989, Accepted 01 Oct 1989, Published online: 09 Jul 2009

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Read on this site (9)

Bojana Milutinović, Sanja Goč, Ninoslav Mitić, Maja Kosanović & Miroslava Janković. (2019) Surface glycans contribute to differences between seminal prostasomes from normozoospermic and oligozoospermic men. Upsala Journal of Medical Sciences 124:2, pages 111-118.
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Göran K. Ronquist, Bo Ek, Gunnar Ronquist, Jane Morrell, Lena Carlsson & Anders Larsson. (2013) Biochemical characterization of stallion prostasomes and comparison to their human counterparts. Systems Biology in Reproductive Medicine 59:6, pages 297-303.
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Alistair B. Stewart, George H. Delves, Brian R. Birch, Alan J. Cooper & Bashir A. Lwaleed. (2009) Antiprostasome antibodies are not an appropriate prognostic marker for prostate cancer. Scandinavian Journal of Urology and Nephrology 43:2, pages 104-108.
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Gunnar Ronquist, Göran Frithz, Yu-Hui Wang & Torsten Lindeborg. (2009) Captopril may reduce biochemical (prostate-specific antigen) failure following radical prostatectomy for clinically localized prostate cancer. Scandinavian Journal of Urology and Nephrology 43:1, pages 32-36.
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B. Ove Nilsson, Meishan Jin & Gunnar Ronquist. (1996) Immunolocalization of Prostasomes in the Human Prostate. Upsala Journal of Medical Sciences 101:2, pages 149-157.
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N. A. Chowdhury, M. Kamada, M. Takikawa, H. Mori, H. Gima & T. Aono. (1996) Complement-Inhibiting Activity of Human Seminal Plasma and Semen Quality. Archives of Andrology 36:2, pages 109-118.
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G. Ronquist, R. Fabiani, M. Jin, B. O. Nilsson, K. Elenbring & S. Hjerten. (1996) Adherence of Human Prostasomes to Mouse Spermatozoa and Their Displacement by Monoclonal Antibodies as Revealed by Free Zone Electrophoresis. Archives of Andrology 36:2, pages 101-107.
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Roberto Fabiani. (1994) Functional and Biochemical Characteristics of Human Prostasomes. Upsala Journal of Medical Sciences 99:2, pages 73-111.
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Articles from other publishers (85)

Larsson Anders, Carlsson Lena, Khierallah Rasha, Holte Jan & Kallak Theodora Kunovac. (2023) Higher levels of Hepatocyte Growth Factor (HGF) in human seminal plasma in comparison with blood plasma and negative association with several motile sperm cells. Global Journal of Fertility and Research 8:1, pages 008-013.
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Sara Larriba, Francesc Vigués & Lluís Bassas. (2023) Using Small Non-Coding RNAs in Extracellular Vesicles of Semen as Biomarkers of Male Reproductive System Health: Opportunities and Challenges. International Journal of Molecular Sciences 24:6, pages 5447.
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Francis K. Fordjour, Chenxu Guo, Yiwei Ai, George G. Daaboul & Stephen J. Gould. (2022) A shared, stochastic pathway mediates exosome protein budding along plasma and endosome membranes. Journal of Biological Chemistry 298:10, pages 102394.
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Erwin L. Muñoz, Fernanda B. Fuentes, Ricardo N. Felmer, Marc Yeste & María E. Arias. (2022) Extracellular vesicles in mammalian reproduction: a review. Zygote 30:4, pages 440-463.
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Eleanor W. Vane, Shushan He, Lutz Maibaum & Abhinav Nath. (2020) Rapid Formation of Peptide/Lipid Coaggregates by the Amyloidogenic Seminal Peptide PAP248-286. Biophysical Journal 119:5, pages 924-938.
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John E. Schjenken & Sarah A. Robertson. (2020) The Female Response to Seminal Fluid. Physiological Reviews 100:3, pages 1077-1117.
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Maria Barceló, Manel Castells, Lluís Bassas, Francesc Vigués & Sara Larriba. (2019) Semen miRNAs Contained in Exosomes as Non-Invasive Biomarkers for Prostate Cancer Diagnosis. Scientific Reports 9:1.
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Valentina Murdica, Greta Chiara Cermisoni, Natasa Zarovni, Andrea Salonia, Paola Viganò & Riccardo Vago. (2019) Proteomic analysis reveals the negative modulator of sperm function glycodelin as over-represented in semen exosomes isolated from asthenozoospermic patients. Human Reproduction 34:8, pages 1416-1427.
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Gretchen van Steenwyk, Ali Jawaid & Isabelle M. Mansuy. 2019. Nutritional Epigenomics. Nutritional Epigenomics 167 190 .
Janine Aucamp, Abel J. Bronkhorst, Christoffel P. S. Badenhorst & Piet J. Pretorius. (2016) A historical and evolutionary perspective on the biological significance of circulating DNA and extracellular vesicles. Cellular and Molecular Life Sciences 73:23, pages 4355-4381.
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Michał Skoczek, Magdalena Nosek & Paweł Weroński. (2016) Voltammetric monitoring of prostasome aggregation and self-fusion. Electrochimica Acta 190, pages 1078-1086.
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Louise Dubois, Karl (K). Göran Ronquist, Bo Ek, Gunnar Ronquist & Anders Larsson. (2015) Proteomic Profiling of Detergent Resistant Membranes (Lipid Rafts) of Prostasomes. Molecular & Cellular Proteomics 14:11, pages 3015-3022.
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Graham D. Johnson, Paula Mackie, Meritxell Jodar, Sergey Moskovtsev & Stephen A. Krawetz. (2015) Chromatin and extracellular vesicle associated sperm RNAs. Nucleic Acids Research 43:14, pages 6847-6859.
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Gunnar Ronquist. 2015. The Male Role in Pregnancy Loss and Embryo Implantation Failure. The Male Role in Pregnancy Loss and Embryo Implantation Failure 191 209 .
Anders WaldenströmGunnar Ronquist. (2014) Role of Exosomes in Myocardial Remodeling. Circulation Research 114:2, pages 315-324.
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K. Göran Ronquist, Bo Ek, Jane Morrell, Anneli Stavreus-Evers, Bodil Ström Holst, Patrice Humblot, Gunnar Ronquist & Anders Larsson. (2013) Prostasomes from four different species are able to produce extracellular adenosine triphosphate (ATP). Biochimica et Biophysica Acta (BBA) - General Subjects 1830:10, pages 4604-4610.
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R. Sullivan & F. Saez. (2013) Epididymosomes, prostasomes, and liposomes: their roles in mammalian male reproductive physiology. Reproduction 146:1, pages R21-R35.
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S. Inayat, A. Larsson, G. K. Ronquist, G. Ronquist, N. Egberg, R. Eliasson & L. Carlsson. (2012) High levels of cathepsins B, L and S in human seminal plasma and their association with prostasomes. Andrologia 44:6, pages 423-427.
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Göran K. Ronquist, Anders Larsson, Anneli Stavreus‐Evers & Gunnar Ronquist. (2012) Prostasomes are heterogeneous regarding size and appearance but affiliated to one DNA‐containing exosome family. The Prostate 72:16, pages 1736-1745.
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Anders Waldenström, Nina Gennebäck, Urban Hellman & Gunnar Ronquist. (2012) Cardiomyocyte Microvesicles Contain DNA/RNA and Convey Biological Messages to Target Cells. PLoS ONE 7:4, pages e34653.
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G. Ronquist. (2011) Prostasomes are mediators of intercellular communication: from basic research to clinical implications. Journal of Internal Medicine 271:4, pages 400-413.
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L. Carlsson, G. Ronquist, G. Ronquist, R. Eliasson, N. Egberg & A. Larsson. (2011) Association of cystatin C with prostasomes in human seminal plasma. International Journal of Andrology 34:4pt1, pages 363-368.
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Göran K. Ronquist, Anders Larsson, Gunnar Ronquist, Anders Isaksson, Julius Hreinsson, Lena Carlsson & Anneli Stavreus‐Evers. (2011) Prostasomal DNA characterization and transfer into human sperm. Molecular Reproduction and Development 78:7, pages 467-476.
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R. Tarazona, E. Delgado, M.C. Guarnizo, R.G. Roncero, S. Morgado, B. Sánchez-Correa, J.J. Gordillo, J. DeJulián & J.G. Casado. (2011) Human prostasomes express CD48 and interfere with NK cell function. Immunobiology 216:1-2, pages 41-46.
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Adil A. Babiker, Peetra U. Magnusson, Gunnar Ronquist, Bo Nilsson & Kristina Nilsson Ekdahl. (2010) Mapping pro‐ and antiangiogenic factors on the surface of prostasomes of normal and malignant cell origin. The Prostate 70:8, pages 834-847.
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H. Pons-Rejraji, B. Sion, F. Saez, F. Brugnon, L. Janny & G. Grizard. (2009) Rôles des dérivés actifs de l’oxygène (DAO) sur les spermatozoïdes humains et infertilité masculine. Gynécologie Obstétrique & Fertilité 37:6, pages 529-535.
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K. Göran Ronquist, Gunnar Ronquist, Lena Carlsson & Anders Larsson. (2009) Human prostasomes contain chromosomal DNA. The Prostate 69:7, pages 737-743.
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Anton Poliakov, Michael Spilman, Terje Dokland, Christopher L. Amling & James A. Mobley. (2008) Structural heterogeneity and protein composition of exosome‐like vesicles (prostasomes) in human semen. The Prostate 69:2, pages 159-167.
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Anuj Goyal, Mridula Chopra & Alan Cooper. 2009. Lycopene. Lycopene 201 224 .
Laura Siciliano, Vito Marcianò & Amalia Carpino. (2008) Prostasome-like vesicles stimulate acrosome reaction of pig spermatozoa. Reproductive Biology and Endocrinology 6:1.
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R W KELLY, P HOLLAND, G SKIBINSKI, C HARRISON, L MCMILLAN, T HARGREAVE & K JAMES. (1991) Extracellular organelles (prostasomes) are immunosuppressive components of human semen. Clinical and Experimental Immunology 86:3, pages 550-556.
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Mark W. Duncan & Heather S. Thompson. (2007) Proteomics of semen and its constituents. PROTEOMICS – CLINICAL APPLICATIONS 1:8, pages 861-875.
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Benjamin Solomon & Mark W. Duncan. 2007. Proteomics of Human Body Fluids. Proteomics of Human Body Fluids 467 493 .
H.P. Burden, C.H. Holmes, R. Persad & K. Whittington. (2006) Prostasomes—their effects on human male reproduction and fertility. Human Reproduction Update 12:3, pages 283-292.
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Adil A. Babiker, Gunnar Ronquist, Bo Nilsson & Kristina Nilsson Ekdahl. (2006) Overexpression of ecto-protein kinases in prostasomes of metastatic cell origin. The Prostate 66:7, pages 675-686.
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Anders Larsson, Gunnar Ronquist, Christian Wülfing, Elke Eltze, Olaf Bettendorf, Lena Carlsson, B. Ove Nilsson & Axel Semjonow. (2006) Antiprostasome antibodies: Possible serum markers for prostate cancer metastasizing liability. Urologic Oncology: Seminars and Original Investigations 24:3, pages 195-200.
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Lidia L. Piehl, Humberto Cisale, Natalia Torres, Francisco Capani, Norma Sterin-Speziale & Alfredo Hager. (2006) Biochemical characterization and membrane fluidity of membranous vesicles isolated from boar seminal plasma. Animal Reproduction Science 92:3-4, pages 401-410.
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B. LWALEED, C. JACKSON, R. GREENFIELD, A. STEWART, G. DELVES, B. BIRCH & A. COOPER. (2006) Seminal tissue factor revisited. International Journal of Andrology 29:2, pages 360-367.
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LENA CARLSSON, GUNNAR RONQUIST, RUNE ELIASSON, NILS EGBERG & ANDERS LARSSON. (2006) Flow cytometric technique for determination of prostasomal quantity, size and expression of CD10, CD13, CD26 and CD59 in human seminal plasma. International Journal of Andrology 29:2, pages 331-338.
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Alessandro Zucchi, Ettore Mearini, Massimo Porena, Enrico Carlini, Carla Saccardi, Giuseppe Arienti & Carlo A. Palmerini. (2006) Cytosolic calcium levels in spermatozoa are modulated differently in healthy subjects and patients with varicocele. Fertility and Sterility 85:1, pages 144-148.
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Johan Malm, Emma Andersson Nordahl, Anders Bjartell, Ole E. Sørensen, Birgitta Frohm, Mieke A. Dentener & Arne Egesten. (2005) Lipopolysaccharide-binding protein is produced in the epididymis and associated with spermatozoa and prostasomes. Journal of Reproductive Immunology 66:1, pages 33-43.
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Lene Udby, Anders Bjartell, Johan Malm, Arne Egesten, Åke Lundwall, Jack B. Cowland, Niels Borregaard & Lars Kjeldsen. (2013) Characterization and Localization of Cysteine‐Rich Secretory Protein 3 (CRISP‐3) in the Human Male Reproductive Tract. Journal of Andrology 26:3, pages 333-342.
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BASHIR A. LWALEED, ROBERT GREENFIELD, ERIC ROYLE, Brian Birch & Alan J. Cooper. (2005) Seminal Factor VIII and von Willebrand Factor: a possible role of the conventional clotting system in human semen?. International Journal of Andrology 28:1, pages 31-38.
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Adil A. Babiker, Bo Nilsson, Gunnar Ronquist, Lena Carlsson & Kristina Nilsson Ekdahl. (2005) Transfer of functional prostasomal CD59 of metastatic prostatic cancer cell origin protects cells against complement attack. The Prostate 62:2, pages 105-114.
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L. Carlsson, A. Larsson, G. Ronquist & B. O. Nilsson. (2004) Prostasome antigens as targets for sperm agglutinating antibodies demonstrated by 1-D gel electrophoresis and immunoblottings. International Journal of Andrology 27:6, pages 360-367.
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Alistair B. Stewart, William Anderson, George Delves, Bashir A. Lwaleed, Brian Birch & Alan Cooper. (2004) Prostasomes: a role in prostatic disease?. BJU International 94:7, pages 985-989.
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Lena Carlsson, Gunnar Ronquist, B. Ove Nilsson & Anders Larsson. (2004) Dominant Prostasome Immunogens for Sperm-Agglutinating Autoantibodies of Infertile Men. Journal of Andrology 25:5, pages 699-705.
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L. Carlsson, B. O. Nilsson, G. Ronquist, M. Lundquist & A. Larsson. (2004) A new test for immunological infertility: an ELISA based on prostasomes. International Journal of Andrology 27:3, pages 130-133.
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G Ronquist & B O Nilsson. (2004) The Janus-faced nature of prostasomes: their pluripotency favours the normal reproductive process and malignant prostate growth. Prostate Cancer and Prostatic Diseases 7:1, pages 21-31.
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Hanae Rejraji & Joeël R. Drevet. (2004) Sécrétions apocrines dans le tractus génital mâle: Roles potentiels dans la maturation des gamètesApocrine secretions in the male genital tract: putative roles in sperm maturation. Andrologie 14:1, pages 22-33.
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G. Arienti, E. Carlini, C. Saccardi & C. A. Palmerini. (2007) Role of human prostasomes in the activation of spermatozoa. Journal of Cellular and Molecular Medicine 8:1, pages 77-84.
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Lena Carlsson, Ove Nilsson, Anders Larsson, Mats Stridsberg, Göran Sahlén & Gunnar Ronquist. (2003) Characteristics of human prostasomes isolated from three different sources. The Prostate 54:4, pages 322-330.
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PIA EK, JOHAN MALM, HANS LILJA, LENA CARLSSON & GUNNAR RONQUIST. (2013) Exogenous Protein Kinases A and C, But Not Endogenous Prostasome‐Associated Protein Kinase, Phosphorylate Semenogelins I and II From Human Semen. Journal of Andrology 23:6, pages 806-814.
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ADIL A. BABIKER, GUNNAR RONQUIST, ULF R. NILSSON & BO NILSSON. (2002) Transfer of Prostasomal CD59 to CD59‐Deficient Red Blood Cells Results in Protection against Complement‐Mediated Hemolysis. American Journal of Reproductive Immunology 47:3, pages 183-192.
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F. Saez, G. Grizard & D. Boucher. (2001) Prostasomes, dérivés actifs de l’oxygène et sperme humainProstasomes, reactive oxygen species and human semen. Andrologie 11:2, pages 33-48.
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Jian Wang, Monalill Lundqvist, Lena Carlsson, Ove Nilsson, Örjan Lundkvist & Gunnar Ronquist. (2001) Prostasome-like granules from the PC-3 prostate cancer cell line increase the motility of washed human spermatozoa and adhere to the sperm. European Journal of Obstetrics & Gynecology and Reproductive Biology 96:1, pages 88-97.
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Lena Carlsson, Carl P�hlson, Magnus Bergquist, Gunnar Ronquist & Mats Stridsberg. (2000) Antibacterial activity of human prostasomes. The Prostate 44:4, pages 279-286.
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Felix G. Kravets, Jacky Lee, Baljeet Singh, Aron Trocchia, Srinivas N. Pentyala & S. Ali Khan. (2000) Prostasomes: Current concepts. The Prostate 43:3, pages 169-174.
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A. Minelli, C. Allegrucci, I. Mezzasoma, G. Ronquist, C. Lluis & R. Franco. (1999) CD26 and Adenosine Deaminase Interaction: Its Role in the Fusion Between Horse Membrane Vesicles and Spermatozoa1. Biology of Reproduction 61:3, pages 802-808.
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B. Ove Nilsson, Lars Egevad, Meishan Jin, Gunnar Ronquist & Christer Busch. (1999) Distribution of prostasomes in neoplastic epithelial prostate cells. The Prostate 39:1, pages 36-40.
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Samir Hamamah, Geneviève Grizard, Alain Fignon, Sharon T. Mortimer & David Mortimer. 1999. Male Sterility and Motility Disorders. Male Sterility and Motility Disorders 95 115 .
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B. Ove Nilsson, Meishan Jin, Barbro Einarsson, Bo-Eric Persson & Gunnar Ronquist. (1998) Monoclonal antibodies against human prostasomes. The Prostate 35:3, pages 178-184.
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Meishan Jin, B. Ove Nilsson, Anders Larsson, Ulf Hellman & Gunnar Ronquist. (1997) The Anti-Human Prostasome MAB 78 binds to an Antigen Distinct from PSA and PAP. The Journal of Urology, pages 1932-1936.
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