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ORIGINAL ARTICLE

MiR-21 modulates human airway smooth muscle cell proliferation and migration in asthma through regulation of PTEN expression

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Pages 535-545 | Received 22 Apr 2015, Accepted 01 Sep 2015, Published online: 11 Dec 2015

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Yi Xiong, Yani Luo, Ting Yuwen, Jiana Li, Rongchang Chen & Fei Shi. (2023) The Regulatory Role of miR-107–Cdk6-Rb Pathway in Airway Smooth Muscle Cells in Asthma. Journal of Asthma and Allergy 16, pages 433-445.
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Haiying Yu, Ningning Qi & Qingxia Zhou. (2021) LncRNA H19 Inhibits Proliferation and Migration of Airway Smooth Muscle Cells Induced by PDGF-BB Through miR-21/PTEN/Akt Axis. Journal of Asthma and Allergy 14, pages 71-80.
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Hwa Young Lee, Hea Yon Lee, Joon Young Choi, Jung Hur, In Kyoung Kim, Young Kyoon Kim, Ji Young Kang & Sook Young Lee. (2017) Inhibition of MicroRNA-21 by an antagomir ameliorates allergic inflammation in a mouse model of asthma. Experimental Lung Research 43:3, pages 109-119.
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Articles from other publishers (42)

Bo Xiao, Liangxian Li, Dong Yao & Biwen Mo. (2023) Noncoding RNAs in asthmatic airway smooth muscle cells. European Respiratory Review 32:168, pages 220184.
Crossref
Shenghao Cheng, Qingping Tang, Shaobing Xie, Sihui Wen, Hua Zhang, Zhihai Xie & Weihong Jiang. (2022) The Role of Noncoding RNA in Airway Allergic Diseases through Regulation of T Cell Subsets. Mediators of Inflammation 2022, pages 1-15.
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Jian Wang & Yuping Cheng. (2022) The interaction of hsa_circ_0002594 and eIF4A3 promotes T-helper 2 cell differentiation by the regulation of PTEN. Clinical and Experimental Medicine 23:3, pages 887-895.
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Shiqing Zhang, Peng Sun, Xinru Xiao, Yujie Hu, Yan Qian & Qian Zhang. (2022) MicroRNA-21 promotes epithelial-mesenchymal transition and migration of human bronchial epithelial cells by targeting poly (ADP-ribose) polymerase-1 and activating PI3K/AKT signaling. The Korean Journal of Physiology & Pharmacology 26:4, pages 239-253.
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Peng Sun, Shiqing Zhang, Di Wu, Yan Qian, Xinru Xiao & Qian Zhang. (2022) MiR-21 modulates proliferation and apoptosis of human airway smooth muscle cells by regulating autophagy via PARP-1/AMPK/mTOR signalling pathway. Respiratory Physiology & Neurobiology 301, pages 103891.
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Bangrong Cai, Liu Yang, Young Do Jung, Ying Zhang, Xinguang Liu, Peng Zhao & Jiansheng Li. (2022) PTEN: An Emerging Potential Target for Therapeutic Intervention in Respiratory Diseases. Oxidative Medicine and Cellular Longevity 2022, pages 1-26.
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Xin Qiao, Gang Hou, Yu-Lin He, Dong-Fang Song, Yi An, Abdullah Altawil, Xiao-Ming Zhou, Qiu-Yue Wang, Jian Kang & Yan Yin. (2022) The Novel Regulatory Role of the lncRNA–miRNA–mRNA Axis in Chronic Inflammatory Airway Diseases. Frontiers in Molecular Biosciences 9.
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Alan J. Knox, Rachel L. Clifford & Klaudia Kaczmarek. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 326 333 .
Dharmendra Kumar Soni & Roopa Biswas. (2021) Role of Non-Coding RNAs in Post-Transcriptional Regulation of Lung Diseases. Frontiers in Genetics 12.
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Ying Cheng, Ning Wang, Long Zhao, Cuicui Liu, Jing Wang, Cailing Ma & Xiaolan Shi. (2021) Knockdown of NOVA1 inhibits inflammation and migration of asthmatic airway smooth muscle cells to regulate PTEN/Akt pathway by targeting PTBP1. Molecular Immunology 138, pages 31-37.
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Pei Gao, Ying Ding, Bingru Yin & Haoxiang Gu. (2021) Long noncoding RNA LINC-PINT retards the abnormal growth of airway smooth muscle cells via regulating the microRNA-26a-5p/PTEN axis in asthma. International Immunopharmacology 99, pages 107997.
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Julie Weidner, Sabine Bartel, Ayse Kılıç, Ulrich M. Zissler, Harald Renz, Jürgen Schwarze, Carsten B. Schmidt‐Weber, Tania Maes, Ana Rebane, Susanne Krauss‐Etschmann & Madeleine Rådinger. (2020) Spotlight on microRNAs in allergy and asthma. Allergy 76:6, pages 1661-1678.
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Jung Hur, Chin Kook Rhee, Sook Young Lee, Young Kyoon Kim & Ji Young Kang. (2021) MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway. The Korean Journal of Internal Medicine 36:3, pages 706-720.
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Xiaoyu Hai, Guozhong Zhao, Zhaolong Li, Junli Wu, Xiangzhao Xu & Yaowen Yang. (2021) Effects of microRNA-103 on the Proliferation and Apoptosis of Pancreatic Cancer Cells via Targeting Phosphatase and Tensin Homolog Deleted on Chromosome Ten (PTEN) and Activating Phosphoinositide 3-Kinase/A Serine/Threonine Kinase (PI3K/Akt) Signaling Pathway. Journal of Biomaterials and Tissue Engineering 11:4, pages 690-696.
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Yan Ding, Yapeng Hou, Yanhong Liu, Xiaoyong Xie, Yong Cui & Hongguang Nie. (2021) Prospects for miR-21 as a Target in the Treatment of Lung Diseases. Current Pharmaceutical Design 27:3, pages 415-422.
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Xudong Li, Fan Zou, Yiyi Lu, Xinping Fan, Yuanyuan Wu, Xiaoli Feng, Xiuzhen Sun & Yun Liu. (2020) Notch1 contributes to TNF-α-induced proliferation and migration of airway smooth muscle cells through regulation of the Hes1/PTEN axis. International Immunopharmacology 88, pages 106911.
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Wei Huo, Yang Li, Yun Zhang & Hai Li. (2020) Mesenchymal stem cells‐derived exosomal microRNA‐21‐5p downregulates PDCD4 and ameliorates erectile dysfunction in a rat model of diabetes mellitus. The FASEB Journal 34:10, pages 13345-13360.
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Soudeh Ghafouri-Fard, Hamed Shoorei, Mohammad Taheri & Marek Sanak. (2020) Emerging role of non-coding RNAs in allergic disorders. Biomedicine & Pharmacotherapy 130, pages 110615.
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Yuanyuan Wu, Yiyi Lu, Fan Zou, Xinping Fan, Xudong Li, Hongni Zhang, Haijuan Chen, Xiuzhen Sun & Yun Liu. (2020) PTEN participates in airway remodeling of asthma by regulating CD38/Ca2+/CREB signaling. Aging 12:16, pages 16326-16340.
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Jose L. Gomez, Ailu Chen, Maria Paula Diaz, Nicholas Zirn, Amolika Gupta, Clemente Britto, Maor Sauler, Xiting Yan, Emma Stewart, Kyle Santerian, Nicole Grant, Qing Liu, Rebecca Fry, Julia Rager, Lauren Cohn, Neil Alexis & Geoffrey L. Chupp. (2020) A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma. American Journal of Respiratory and Critical Care Medicine 202:1, pages 51-64.
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Hui Zhang, Huan‐Li Yan, Xiang‐Yu Li & Yi‐Nan Guo. (2020) TNFSF14, a novel target of miR‐326, facilitates airway remodeling in airway smooth muscle cells via inducing extracellular matrix protein deposition and proliferation. The Kaohsiung Journal of Medical Sciences 36:7, pages 508-514.
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Zhaochuan Yang, Zhenghai Qu, Mingji Yi, Zhidong Lv, Yanxia Wang, Yanchun Shan, Ni Ran & Xinjie Liu. (2020) MiR-204-5p Inhibits Transforming Growth Factor-β1-Induced Proliferation and Extracellular Matrix Production of Airway Smooth Muscle Cells by Regulating Six1 in Asthma. International Archives of Allergy and Immunology 181:4, pages 239-248.
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Sébastien Bonnet, Olivier Boucherat, Roxane Paulin, Danchen Wu, Charles C. T. Hindmarch, Stephen L. Archer, Rui Song, Joseph B. MooreIVIV, Steeve Provencher, Lubo Zhang & Shizuka Uchida. (2020) Clinical value of non-coding RNAs in cardiovascular, pulmonary, and muscle diseases. American Journal of Physiology-Cell Physiology 318:1, pages C1-C28.
Crossref
Mengying Li, Zijie Zhang, Xiuge Gu, Ye Jin, Cheng Feng, Shuangyan Yang & Fulan Wei. (2019) MicroRNA‐21 affects mechanical force–induced midpalatal suture remodelling. Cell Proliferation 53:1.
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Congshan Jiang, Yuanxu Guo, Hongchuan Yu, Shemin Lu & Liesu Meng. (2019) Pleiotropic microRNA-21 in pulmonary remodeling: novel insights for molecular mechanism and present advancements. Allergy, Asthma & Clinical Immunology 15:1.
Crossref
Seyed Reza Mousavi, Ali Ahmadi, Sadegh Azimzadeh Jamalkandi & Jafar Salimian. (2019) Involvement of microRNAs in physiological and pathological processes in asthma. Journal of Cellular Physiology 234:12, pages 21547-21559.
Crossref
X. Huang, B. Liu & L. Tian. (2019) Intranasal concentration gradient of yupingfeng promotes induction of microRNA-21 by PTEN to reverse activation of OVA mimicking allergic rhinitis. Revue Française d'Allergologie 59:7, pages 481-486.
Crossref
Changchun Hou, Yan Chen, Xiaolin Huang, Qinghua Huang, Mengze Li & Xiaoyu Tan. (2019) miR-19 targets PTEN and mediates high mobility group protein B1(HMGB1)-induced proliferation and migration of human airway smooth muscle cells. PLOS ONE 14:6, pages e0219081.
Crossref
Klaudia A. Kaczmarek, Rachel L. Clifford & Alan J. Knox. (2019) Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma. Chest 155:4, pages 816-824.
Crossref
Yan Chen, Lujun Qiao, Zewen Zhang, Guoxin Hu, Jian Zhang & Hongjia Li. (2019) Let‑7a inhibits proliferation and promotes apoptosis of human asthmatic airway smooth muscle cells. Experimental and Therapeutic Medicine.
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Lei Fang, Xinggang Wang, Qingzhu Sun, Eleni Papakonstantinou, Chongteck S’ng, Michael Tamm, Daiana Stolz & Michael Roth. (2019) IgE Downregulates PTEN through MicroRNA-21-5p and Stimulates Airway Smooth Muscle Cell Remodeling. International Journal of Molecular Sciences 20:4, pages 875.
Crossref
Xun Li, Chuang Li, Ganghua Zhu, Wenhui Yuan & Zi-an Xiao. (2019) TGF-β1 Induces Epithelial-Mesenchymal Transition of Chronic Sinusitis with Nasal Polyps through MicroRNA-21. International Archives of Allergy and Immunology 179:4, pages 304-319.
Crossref
Lu Liu, Yilin Pan, Cui Zhai, Yanting Zhu, Rui Ke, Wenhua Shi, Jian Wang, Xin Yan, Xiaofan Su, Yang Song, Li Gao & Manxiang Li. (2018) Activation of peroxisome proliferation–activated receptor‐γ inhibits transforming growth factor‐β1‐induced airway smooth muscle cell proliferation by suppressing Smad–miR‐21 signaling. Journal of Cellular Physiology 234:1, pages 669-681.
Crossref
Rong Jin, Sujuan Hu, Xiaomei Liu, Renzheng Guan, Ling Lu & Rongjun Lin. (2018) Intranasal instillation of miR‑410 targeting IL‑4/IL‑13 attenuates airway inflammation in OVA‑induced asthmatic mice. Molecular Medicine Reports.
Crossref
Jin Tang & Lingying Luo. (2018) MicroRNA-20b-5p inhibits platelet-derived growth factor-induced proliferation of human fetal airway smooth muscle cells by targeting signal transducer and activator of transcription 3. Biomedicine & Pharmacotherapy 102, pages 34-40.
Crossref
Yamei Ji, Xin Yang & Huixia Su. (2018) Overexpression of microRNA-375 impedes platelet-derived growth factor-induced proliferation and migration of human fetal airway smooth muscle cells by targeting Janus kinase 2. Biomedicine & Pharmacotherapy 98, pages 69-75.
Crossref
Yujia Shi, Xingli Fu, Qi Cao, Zhengdao Mao, Yi Chen, Yun Sun, Zhiguang Liu & Qian Zhang. (2018) Overexpression of miR-155-5p Inhibits the Proliferation and Migration of IL-13-Induced Human Bronchial Smooth Muscle Cells by Suppressing TGF-β-Activated Kinase 1/MAP3K7-Binding Protein 2. Allergy, Asthma & Immunology Research 10:3, pages 260.
Crossref
Ruili Zhao, Ke Shi & Pei Fan. (2017) miR-21-5p is associated with the regulation of estradiol benzoate and oxytocin induced primary dysmenorrhea in rat uterus: a bioinformatic study. Genes & Genomics 39:11, pages 1255-1263.
Crossref
Jose L. Gomez, Xiting Yan, Carole T. Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova, Deborah A. Meyers, Eugene R. Bleecker, Gina M. Crisafi, Nizar N. Jarjour, Linda Rogers, Joan Reibman & Geoffrey L. Chupp. (2017) Characterisation of asthma subgroups associated with circulating YKL-40 levels. European Respiratory Journal 50:4, pages 1700800.
Crossref
Zhihong Wang, Yifan Wu, Jianing Wang, Chuangnian Zhang, Hongyu Yan, Meifeng Zhu, Kai Wang, Chen Li, Qingbo XuDeling Kong. (2017) Effect of Resveratrol on Modulation of Endothelial Cells and Macrophages for Rapid Vascular Regeneration from Electrospun Poly(ε-caprolactone) Scaffolds. ACS Applied Materials & Interfaces 9:23, pages 19541-19551.
Crossref
N. Coll-Bonfill, B. de la Cruz-Thea, M. V. Pisano & M. M. Musri. (2016) Noncoding RNAs in smooth muscle cell homeostasis: implications in phenotypic switch and vascular disorders. Pflügers Archiv - European Journal of Physiology 468:6, pages 1071-1087.
Crossref
Izabela Szymczak, Joanna Wieczfinska & Rafal Pawliczak. (2016) Molecular Background of miRNA Role in Asthma and COPD: An Updated Insight. BioMed Research International 2016, pages 1-10.
Crossref

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