Advanced search
Publication Cover
Experimental Lung Research Volume 2, 1981 - Issue 3
Submit an article Journal homepage
10
Views
79
CrossRef citations to date
0
Altmetric
Original Article

Identification of Cytochrome P-450 Isozymes in Nonciliated Bronchiolar Epithelial (Clara) and Alveolar Type II Cells Isolated from Rabbit Lung

Theodora R. Devereux Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
,
Cosette J. Serabjit-singh Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
,
Shelley R. Slaughter Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
,
C. Roland Wolf Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
,
Richard M. Philpot Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
&
James R. Fouts Laboratory of Pharmacology, National Institute of Environmental Health Sciences, N1H. P.O. Box 12233, Research Triangle Park, North Carolina, 27709
Pages 221-230 | Received 20 Dec 1980, Accepted 12 Mar 1981, Published online: 02 Jul 2009

Citations (79)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (10)

Brian R. Baer & Allan E. Rettie. (2006) CYP4B1: An Enigmatic P450 at the Interface between Xenobiotic and Endobiotic Metabolism. Drug Metabolism Reviews 38:3, pages 451-476.
Read now
Fred H. Royce & Charles G. Plopper. (1997) Effect of Chronic Daily Ozone Exposure on Clara Cell Secretory Protein mRNA Expression in the Adult Rat Lung. Experimental Lung Research 23:1, pages 51-64.
Read now
Heidi Foth. (1995) Role of the Lung in Accumulation and Metabolism of Xenobiotic Compounds — Implications for Chemically Induced Toxicity. Critical Reviews in Toxicology 25:2, pages 165-205.
Read now
T. T. Kawabata & K. L. White$suffix/text()$suffix/text(). (1990) Effects of naphthalene and naphthalene metabolites on the in vitro humoral immune response. Journal of Toxicology and Environmental Health 30:1, pages 53-67.
Read now
York E. Miller, Susan R. Walker, John S. Spencer, Ralph X Kubo & Robert J. Mason. (1989) Monoclonal Antibodies Specific for Antigens Expressed by Rat Type II Alveolar Epithelial and Nonciliated Bronchiolar Cells. Experimental Lung Research 15:4, pages 635-649.
Read now
Susan R. Walker, Sandra Hale, Alvin M. Malkinson & Robert J. Mason. (1989) Properties of Isolated Nonciliated Bronchiolar Cells from Mouse Lung. Experimental Lung Research 15:4, pages 553-573.
Read now
Leif-å Svensson & Anders Tunek. (1988) The design and bioactivation of presystemically stable prodrugs. Drug Metabolism Reviews 19:2, pages 165-194.
Read now
C. G. Plopper, D. L. Cranz, L. Kemp, C. J. Serabjit-Singh & R. M. Philpot. (1987) Immunohistochemical Demonstration of Cytochrome P-450 Monooxygenase in Clara Cells throughout the Tracheobronchial Airways of the Rabbit. Experimental Lung Research 13:1, pages 59-68.
Read now
Suzanne E. Patton, Linda B. Gilmore, Anton M. Jetten, Paul Nettesheim & Gary E. R. Hook. (1986) Biosynthesis and Release of Proteins by Isolated Pulmonary Clara Cells. Experimental Lung Research 11:4, pages 277-294.
Read now
Y. Takahashi, T. Miura & K. Kubota. (1985) In vivo effect of ozone inhalation on xenobiotic metabolism of lung and liver of rats. Journal of Toxicology and Environmental Health 15:6, pages 855-864.
Read now

Articles from other publishers (69)

Andrew J. Gow & Henry J. Forman. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 355 374 .
A. E. Bishop. (2004) Pulmonary epithelial stem cells. Cell Proliferation 37:1, pages 89-96.
Crossref
Junko Itoh, Yoko Kashida, Takao Watanabe, Kazuo Yasuhara, Tamotsu Takizawa, Makoto Ueda, Hiroyuki Yoshimura, Masao Hirose & Kunitoshi Mitsumori. (2002) Lack of Modifying Effect of Glycerol in Pulmonary Carcinogenesis in rasH2 Mice Induced by Urethane or 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Journal of Toxicologic Pathology 15:4, pages 215-220.
Crossref
Catherine Benoit, Barbara Renaudon, Dany Salvail & Eric Rousseau. (2001) EETs relax airway smooth muscle via an EpDHF effect: BK Ca channel activation and hyperpolarization . American Journal of Physiology-Lung Cellular and Molecular Physiology 280:5, pages L965-L973.
Crossref
Alvin M Malkinson, Lori D Dwyer-Nield, Pamela L Rice & David Dinsdale. (1997) Mouse lung epithelial cell lines—tools for the study of differentiation and the neoplastic phenotype. Toxicology 123:1-2, pages 53-100.
Crossref
Anna Clouter & Roy J. Richards. (1997) Extracellular biotransformation potential in mouse airways. The International Journal of Biochemistry & Cell Biology 29:3, pages 521-527.
Crossref
Annie Buard, Annie Renier, Marie‐Claude Jaurand, Jean Bignon, Philippe Laurent & Philippe H. Beaune. (2005) Expression of cytochrome P450 in rat pleural mesothelial cells in secondary cultures. Journal of Cellular Physiology 160:1, pages 176-184.
Crossref
Shigeharu Kudo. (2005) Differentiation of clara cells and pneumocytes of the rat by means of enzyme‐ and immunohistochemistry. The Anatomical Record 238:1, pages 49-56.
Crossref
Hitoshi Kitamura, Thomas E. Gray, Anton M. Jetten, Yoshiaki Inayama & Paul Nettesheim. (2005) Enhanced Growth Potential of Cultured Rahbit Tracheal Epithelial Cells Following Exposure to N‐Methyl‐N′‐nitro‐N‐nitrosoguanidine. Japanese Journal of Cancer Research 84:11, pages 1113-1119.
Crossref
Taketoshi Suehiro, Teruyoshi Ishida, Kenji Sugio, Keizo Sugimachi & Katsuo Sueishi. (2006) Monoclonal antibody KP 16D3 as a prognostic marker in stage I lung adenocarcinoma. Journal of Surgical Oncology 54:1, pages 51-56.
Crossref
B. Nemery & P.H.M. Hoet. (1993) Use of isolated lung cells in pulmonary toxicology. Toxicology in Vitro 7:4, pages 359-364.
Crossref
Rune Becher, Marit Låg, Per E. Schwarze, Gunnar Brunborg, Erik J. Søderlund & Jørn A. Holme. (1993) Chemically induced DNA damage in isolated rabbit lung cells. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 285:2, pages 303-311.
Crossref
Alvin M. Malkinson, Francis B. Miley, Christine H. Chichester & Charles G. Plopper. 1993. In Vitro Biological Systems. In Vitro Biological Systems 123 133 .
JEFFREY BARON & JEFFREY M. VOIGT. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 41 75 .
THEODORA R. DEVEREUX, BARBARA A. DOMIN & RICHARD M. PHILPOT. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 25 40 .
James W. Fisher. 2011. Comprehensive Physiology. Comprehensive Physiology 2407 2438 .
Sisko Anttila, Eino Hietanen, Hard Vainio, Anne-Marie Camus, Harry V. Gelboin, Sang S. Park, Lasse Heikkilä, Antti Karjalainen & Helmut Bartsch. (1991) Smoking and peripheral type of cancer are related to high levels of pulmonary cytochrome P450IA in lung cancer patients. International Journal of Cancer 47:5, pages 681-685.
Crossref
Åke Ryrfeldt, Ian A. Cotgreave & Peter Moldéus. (2020) In Vitro Models to Study Mechanisms of Lung Toxicity . Alternatives to Laboratory Animals 18:1_part_1, pages 267-281.
Crossref
Jon E. Dahl, Rune Becher, Marit L�g, Hildegard M. Schuller & Erik Dybing. (1990) Formation of genotoxic products from N-nitrosoheptamethyleneimine (NHMI), 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) and N?-Nitrosonornicotine (NNN) by isolated rabbit lung cells. Cell Biology and Toxicology 6:4, pages 399-409.
Crossref
Craig B. Marcus, Neil M. Wilson, Ingegerd M. Keith, Colin R. Jefcoate & Curtis J. Omiecinski. (1990) Selective expression of cytochrome P450 isozymes by 4-n-alkyl-methylenedioxybenzenes in rat lung cells. Archives of Biochemistry and Biophysics 277:1, pages 17-25.
Crossref
S. Dutta, M. Chatterjee, T.N. Teknos & R.W. Carlson. (1990) A study of ozone-induced edema in the isolated rat lung in relation to arachidonic acid metabolism, mixed-function oxidases and angiotensin converting enzyme activities. Pulmonary Pharmacology 3:2, pages 65-72.
Crossref
Jeffrey Baron & Jeffrey M. Voigt. (1990) Localization, distribution, and induction of xenobiotic-metabolizing enzymes and aryl hydrocarbon hydroxylase activity within lung. Pharmacology & Therapeutics 47:3, pages 419-445.
Crossref
Kym A.F. O'Brien, Claus Suverkropp, Sarathchandra Kanekal, Charles G. Plopper & Alan R. Buckpitt. (1989) Tolerance to multiple doses of the pulmonary toxicant, naphthalene. Toxicology and Applied Pharmacology 99:3, pages 487-500.
Crossref
Alan R. Buckpitt & Ronald B. Franklin. (1989) Relationship of naphthalene and 2-methylnaphthaline metabolism to pulmonary bronchiolar epithelial cell necrosis. Pharmacology & Therapeutics 41:1-2, pages 393-410.
Crossref
Theodora R. Devereux, Barbara A. Domin & Richard M. Philpot. (1989) Xenobiotic metabolism by isolated pulmonary cells. Pharmacology & Therapeutics 41:1-2, pages 243-256.
Crossref
Tzuu‐Huei Ueng, Martha D. Peiperl & Alvito P. Alvares. (2006) Chromatographic and catalytic properties of multiple forms of rabbit pulmonary cytochromes P‐450. Journal of Biochemical Toxicology 3:4, pages 343-352.
Crossref
A. Lopez, M. Prior, L. E. Lilue, C. Gulayets & O. S. Atwal. (2016) Histologic and Ultrastructural Alterations in Lungs of Rats Exposed to Sub-lethal Concentrations of Hydrogen Sulfide. Veterinary Pathology 25:5, pages 376-384.
Crossref
Paul R. Richieri & Alan R. Buckpitt. (1988) Glutathione depletion by naphthalene in isolated hepatocytes and by naphthalene oxide in vivo. Biochemical Pharmacology 37:12, pages 2473-2478.
Crossref
David P. Penney. 1988. 231 269 .
Pia Larsson & Hans Tj?lve. (1988) Tracing tissues with 4-ipomeanol-metabolizing capacity in rats. Chemico-Biological Interactions 67:1-2, pages 1-24.
Crossref
H. Iwainsky. 1988. Antituberculosis Drugs. Antituberculosis Drugs 399 553 .
Eivor Elovaara, Antti Zitting, Juha Nickels & Antero Aitio. (1987) m-Xylene inhalation destroys cytochrome P-450 in rat lung at low exposure. Archives of Toxicology 61:1, pages 21-26.
Crossref
Ann F. Welton, Margaret O'Donnell & Douglas W. Morgan. 1987. Advances in Clinical Chemistry Volume 26. Advances in Clinical Chemistry Volume 26 293 383 .
F. De Matteis & E. A. LockLewis L. Smith & Benoit Nemery. 1987. Selectivity and Molecular Mechanisms of Toxicity. Selectivity and Molecular Mechanisms of Toxicity 3 26 .
John R. Foster, Clifford R. Elcombe, Alan R. Boobis, Donald S. Davies, Dorothea Sesardic, Jamie McQuade, Richard T. Robson, Christopher Hayward & Edward A. Lock. (1986) Immunocytochemical localization of cytochrome P-450 in hepatic and extra-hepatic tissues of the rat with a monoclonal antibody against cytochrome P-450 c. Biochemical Pharmacology 35:24, pages 4543-4554.
Crossref
Alan R. Buckpitt & Linda S. Bahnson. (1986) Naphthalene metabolism by human lung microsomal enzymes. Toxicology 41:3, pages 333-341.
Crossref
Happei Miyakawa, Enrique Baraona, Jui C. Chang, Marvin D. Lesser & Charles S. Lieber. (2007) Oxidation of Ethanol to Acetaldehyde by Bronchopulmonary Washings: Role of Bacteria. Alcoholism: Clinical and Experimental Research 10:5, pages 517-520.
Crossref
P.G. Forkert, V. Stringer & W.J. Racz. (1986) Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice. Experimental and Molecular Pathology 45:1, pages 44-58.
Crossref
Alan R. Buckpitt, Linda S. Bahnson & Ronald B. Franklin. (1986) Comparison of the arachidonic acid and NADPH-dependent microsomal metabolism of naphthalene and 2-methylnaphthalene and the effect of indomethacin on the bronchiolar necrosis. Biochemical Pharmacology 35:4, pages 645-650.
Crossref
Aron B. Fisher & Henry J. Forman. 2011. Comprehensive Physiology. Comprehensive Physiology 231 254 .
Thomas E. Massey & James R. Fouts. (1985) Mixed-function oxidase activity in enriched populations of ciliated cells freshly isolated from rabbit tracheas. Cell Biology and Toxicology 1:4, pages 297-308.
Crossref
Tore Aune, Theodora R. Devereux & Kristi Tveito. (1985) Metabolism of 2-acetylaminofluorene by clara cells, type II cells and alveolar macrophages isolated from rabbit lung, and use of a new chamber incubation mutagenicity test system. Cell Biology and Toxicology 1:3, pages 109-122.
Crossref
Kym A.F. O'Brien, Lewis L. Smith & Gerald M. Cohen. (1985) Differences in naphthalene-induced toxicity in the mouse and rat. Chemico-Biological Interactions 55, pages 109-122.
Crossref
Theodora R. Devereux, Janet J. Diliberto & James R. Fouts. (1985) Cytochrome P-450 monooxygenase, epoxide hydrolase and flavin monooxygenase activities in clara cells and alveolar type II cells isolated from rabbit. Cell Biology and Toxicology 1:2, pages 57-65.
Crossref
D. L. Dungworth, W. S. Tyler & C. E. Plopper. 1985. Toxicology of Inhaled Materials. Toxicology of Inhaled Materials 229 258 .
A. B. Fisher. 1985. Toxicology of Inhaled Materials. Toxicology of Inhaled Materials 149 179 .
T. E. Gram. 1985. Toxicology of Inhaled Materials. Toxicology of Inhaled Materials 421 470 .
Minro Watanabe, Ikuko Sagami, Tetsuo Ohmachi & Hiroshi Fujii. 1985. P-450 and Chemical Carcinogenesis. P-450 and Chemical Carcinogenesis 19 36 .
Eva Brittebo & Ingvar Brandt. (1984) Metabolism of chlorobenzene in the mucosa of the murine respiratory tract. Lung 162:1, pages 79-88.
Crossref
G. Lungarella, I. Barni-Comparini & L. Fonzi. (1984) Pulmonary changes induced in rabbits by long-term exposure to n-hexane. Archives of Toxicology 55:4, pages 224-228.
Crossref
J. Gandy, F.A.F. Ali, L. Hasegawa & T. Imamura. (1984) Morphological alterations of rat lung bronchiolar epithelium produced by various trialkyl phosphorothioates. Toxicology 32:1, pages 37-46.
Crossref
Eva B. Brittebo & Maria Åhlman. (1984) Metabolism of a nasal carcinogen, phenacetin, in the mucosa of the upper respiratory tract. Chemico-Biological Interactions 50:2, pages 233-245.
Crossref
T R Devereux. (1984) Alveolar type II and Clara cells: isolation and xenobiotic metabolism.. Environmental Health Perspectives 56, pages 95-101.
Crossref
I Linnoila & P Petrusz. (1984) Immunohistochemical techniques and their applications in the histopathology of the respiratory system.. Environmental Health Perspectives 56, pages 131-148.
Crossref
Klaas R. Krijgsheld, Michael C. Lowe, Edward G. Mimnaugh, Michael A. Trush, Erika Ginsburg & Theodore E. Gram. (1984) Selective damage to nonciliated bronchiolar epithelial cells in relation to impairment of pulmonary monooxygenase activities by 1,1-dichloroethylene in mice. Toxicology and Applied Pharmacology 74:2, pages 201-213.
Crossref
Klaas R. Krijgsheld & Theodore E. Gram. (1984) Selective induction of renal microsomal cytochrome P-450-linked monooxygenases by 1,1-dichloroethylene in mice. Biochemical Pharmacology 33:12, pages 1951-1956.
Crossref
Norma Fakjian & Alan R. Buckpitt. (1984) Metabolism of bromobenzene to glutathione adducts in lung slices from mice treated with pneumotoxicants. Biochemical Pharmacology 33:9, pages 1479-1486.
Crossref
R M Philpot & B R Smith. (1984) Role of cytochrome P-450 and related enzymes in the pulmonary metabolism of xenobiotics.. Environmental Health Perspectives 55, pages 359-367.
Crossref
A B Fisher. (1984) Intermediary metabolism of the lung.. Environmental Health Perspectives 55, pages 149-158.
Crossref
Aron B. Fisher & Jayne Reicherter. (1984) Pentose pathway of glucose metabolism in isolated granular pneumocytes. Biochemical Pharmacology 33:8, pages 1349-1353.
Crossref
B. A. Domin, C. J. Serabjit-Singh, R. R. Vanderslice, T. R. Devereux, J. R. Fouts, J. R. Bend & R. M. Philpot. 1984. IUPHAR 9th International Congress of Pharmacology London 1984. IUPHAR 9th International Congress of Pharmacology London 1984 219 224 .
James A. Bond, Charles E. Mitchell & Albert P. Li. (1983) Metabolism and macromolecular covalent binding of benzo[a]pyrene in cultured fischer-344 rat lung type II epithelial cells. Biochemical Pharmacology 32:24, pages 3771-3776.
Crossref
Hans Tjälve & Boël Löfberg. (1983) Extrahepatic sites of metabolism of carbon tetrachloride in rats. Chemico-Biological Interactions 46:3, pages 299-316.
Crossref
Charles G. Plopper, Janice L. Alley, Cosette J. Serabjitsingh & Richard M. Philpot. (2005) Cytodifferentiation of the nonciliated bronchiolar epithelial (Clara) cell during rabbit lung maturation: An ultrastructural and morphometric study. American Journal of Anatomy 167:3, pages 329-357.
Crossref
Gregory Smart & Alan R. Buckpitt. (1983) Formation of reactive naphthalene metabolites by target vs non-target tissue microsomes: Methods for the separation of three glutathione adducts. Biochemical Pharmacology 32:5, pages 943-946.
Crossref
Jeffrey Baron & Thomas T. Kawabata. 1983. Biological Basis of Detoxication. Biological Basis of Detoxication 105 135 .
Eva B. Brittebo. (2009) N‐Demethylation of Aminopyrine by the Nasal Mucosa in Mice and Rats. Acta Pharmacologica et Toxicologica 51:3, pages 227-232.
Crossref
James R. Fouts. (1982) The metabolism of xenobiotics by isolated pulmonary and skin cells. Trends in Pharmacological Sciences 3, pages 164-166.
Crossref
John R. Bend, Brian R. Smith, Louise M. Ball, John L. Plummer, C. Roland Wolf, Richard M. Philpot, Theodora R. Devereux & James R. Fouts. 1982. Biological Reactive Intermediates—II. Biological Reactive Intermediates—II 541 554 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.