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Experimental Lung Research Volume 9, 1985 - Issue 1-2
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Original Article

Proteolytic Activity of Human Neutrophil Elastase and Porcine Pancreatic Trypsin Causes Bronchial Secretory Cell Metaplasia in Hamsters

Raphael Breuer Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, the Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, and the Evans Department of Clinical Research of University Hospital, Boston, Massachusetts
,
Edgar C. Lucey Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, the Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, and the Evans Department of Clinical Research of University Hospital, Boston, Massachusetts
,
Phillip J. Stone Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, the Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, and the Evans Department of Clinical Research of University Hospital, Boston, Massachusetts
,
Thomas G. Christensen Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, the Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, and the Evans Department of Clinical Research of University Hospital, Boston, Massachusetts
&
Gordon L. Snider Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, the Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, and the Evans Department of Clinical Research of University Hospital, Boston, Massachusetts
Pages 167-175 | Received 30 Jul 1984, Published online: 02 Jul 2009

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Kristen J. Nikula & Francis H. Y. Green. (2000) ANIMAL MODELS OF CHRONIC BRONCHITIS AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE. Inhalation Toxicology 12:sup4, pages 123-153.
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S. Jamil, R. Breuer & T. G. Christensen. (1997) Abnormal Mucous Cell Phenotype Induced by Neutrophil Elastase in Hamster Bronchi. Experimental Lung Research 23:4, pages 285-295.
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Thomas G. Christensen, Raphael Breuer, Christopher E. Haddad, Edgar C. Lucey, Phillip J. Stone & Gordon L. Snider. (1992) Resistance of Hamster Bronchiolar Epithelium to Neutrophil Elastase: Investigation by Cell Surface Lectin Cytochemistry. Experimental Lung Research 18:1, pages 115-129.
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E. C. Lucey, P. J. Stone, T. G. Christensen, R. Breuer & G. L. Snider. (1988) An 18-Month Study of the Effects on Hamster Lungs of Intratracheally Administered Human Neutrophil Elastase. Experimental Lung Research 14:5, pages 671-686.
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Articles from other publishers (22)

Lillian Chow, David Smith, Khushboo Chokshi, Wendy Ezegbunam, Prangthip Charoenpong, Kimberly Foley, Adrian Cargill & Patrick Geraghty. 2018. COPD - An Update in Pathogenesis and Clinical Management. COPD - An Update in Pathogenesis and Clinical Management.
Marisa L. MeyerErin N. Potts-Kant, Andrew J. Ghio, Bernard M. FischerW. Michael Foster & Judith A. Voynow. (2012) NAD(P)H quinone oxidoreductase 1 regulates neutrophil elastase-induced mucous cell metaplasia. American Journal of Physiology-Lung Cellular and Molecular Physiology 303:3, pages L181-L188.
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Hongwei Yao, Indika Edirisinghe, Se-Ran Yang, Saravanan Rajendrasozhan, Aruna Kode, Samuel Caito, David Adenuga & Irfan Rahman. (2008) Genetic Ablation of NADPH Oxidase Enhances Susceptibility to Cigarette Smoke-Induced Lung Inflammation and Emphysema in Mice. The American Journal of Pathology 172:5, pages 1222-1237.
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Ali RoghanianJean-Michel Sallenave. (2008) Neutrophil Elastase (NE) and NE Inhibitors: Canonical and Noncanonical Functions in Lung Chronic Inflammatory Diseases (Cystic Fibrosis and Chronic Obstructive Pulmonary Disease). Journal of Aerosol Medicine and Pulmonary Drug Delivery 21:1, pages 125-144.
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Ali Roghanian & Jean-Michel Sallenave. (2008) Neutrophil Elastase (NE) and NE Inhibitors: Canonical and Noncanonical Functions in Lung Chronic Inflammatory Diseases (Cystic Fibrosis and Chronic Obstructive Pulmonary Disease). Journal of Aerosol Medicine 0:0, pages 080207080519480-20.
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Mary Callaghan Rose & Judith A. Voynow. (2006) Respiratory Tract Mucin Genes and Mucin Glycoproteins in Health and Disease. Physiological Reviews 86:1, pages 245-278.
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Judith A. Voynow, Bernard M. Fischer, David E. Malarkey, Lauranell H. Burch, Teresa Wong, Malinda Longphre, Samuel B. Ho & W. Michael Foster. (2004) Neutrophil elastase induces mucus cell metaplasia in mouse lung. American Journal of Physiology-Lung Cellular and Molecular Physiology 287:6, pages L1293-L1302.
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Markus O. Henke, Armin Renner, Rudolf M. Huber, Michael C. Seeds & Bruce K. Rubin. (2004) MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. American Journal of Respiratory Cell and Molecular Biology 31:1, pages 86-91.
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George D. Leikauf, Michael T. Borchers, Daniel R. Prows & Leigh G. Simpson. (2002) Mucin Apoprotein Expression in COPD. Chest 121:5, pages 166S-182S.
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Judith A. Voynow, Lisa Rosenthal Young, Yiqiong Wang, Teresa Horger, Mary C. Rose & Bernard M. Fischer. (1999) Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells . American Journal of Physiology-Lung Cellular and Molecular Physiology 276:5, pages L835-L843.
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Shu Hashimoto, Shuichiro Maruoka, Yasuhiro Gon, Ken Matsumoto, Ikuko Takeshita & Takashi Horie. (1999) Mitogen-activated protein kinase involves neutrophil elastase-induced morphological changes in human bronchial epithelial cells. Life Sciences 64:16, pages 1465-1471.
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Dechun Li & Peter K. Jeffery. 1997. Airway Mucus: Basic Mechanisms and Clinical Perspectives. Airway Mucus: Basic Mechanisms and Clinical Perspectives 227 273 .
Takaaki Ito, Yoshiaki Ikemi, Kaoru Ohmori, Hitoshi Kitamura & Masayoshi Kanisawa. (1994) Airway epithelial cell changes in rats exposed to 0.25 ppm ozone for 20 months. Experimental and Toxicologic Pathology 46:1, pages 1-6.
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R. Breuer, T. G. Christensen, Y. Wax, G. Bolbochan, E. C. Lucey, P. J. Stone & G. L. Snider. (1993) Relationship of Secretory Granule Content and Proliferative Intensity in the Secretory Compartment of the Hamster Bronchial Epithelium. American Journal of Respiratory Cell and Molecular Biology 8:5, pages 480-485.
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T D Tetley. (1993) New perspectives on basic mechanisms in lung disease. 6. Proteinase imbalance: its role in lung disease.. Thorax 48:5, pages 560-565.
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Kathleen A. Rickard, Janice Taylor & Stephen I. Rennard. (1992) Observations of Development of Resistance to Detachment of Cultured Bovine Bronchial Epithelial Cells in Response to Protease Treatment. American Journal of Respiratory Cell and Molecular Biology 6:4, pages 414-420.
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Gordon L. Snider. (1992) Animal Models of Chronic Airways Injury. Chest 101:3, pages 74S-79S.
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STEPHEN I. RENNARD, KATHLEEN RICKARD, JOE D. BECKMANN, GUILLERMO HUERTA, SEKIYA KOYAMA, RICHARD A. ROBBINS, DEBRA ROMBERGER, JOHN SPURZEM & AUSTIN B. THOMPSON. (1991) Protease Injury in Airways Disease. Annals of the New York Academy of Sciences 624:1, pages 278-285.
Crossref
Thomas G. Christensen, Raphael Breuer, Edgar C. Lucey, Linda J. Hornstra, Phillip J. Stone & Gordon L. Snider. (1990) Lectin Cytochemistry Reveals Differences between Hamster Trachea and Bronchus in the Composition of Epithelial Surface Glycoconjugates and in the Response of Secretory Cells to Neutrophil Elastase. American Journal of Respiratory Cell and Molecular Biology 3:1, pages 61-69.
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Jens D. Lundgren & James H. Shelhamer. (1990) Pathogenesis of airway mucus hypersecretion. Journal of Allergy and Clinical Immunology 85:2, pages 399-417.
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R. Breuer, T. G. Christensen, R. M. Niles, P. J. Stone & G. L. Snider. (1989) Human Neutrophil Elastase Causes Glycoconjugate Release from the Epithelial Cell Surface of Hamster Trachea in Organ Culture. American Review of Respiratory Disease 139:3, pages 779-782.
Crossref
T.G. Christensen, E.C. Lucey, R. Breuer & G.L. Snider. (1988) Acid-induced secretory cell metaplasia in hamster bronchi. Environmental Research 45:1, pages 78-90.
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