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Experimental Lung Research Volume 13, 1987 - Issue 1
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Original Article

Platelet Activating Factor Stimulates Secretion of Mucin by Explants of Rodent Airways in Organ Culture

Kenneth B. Adler Department of Pathology, College of Medicine, University of Vermont, Burlington, Nutley, NJ; Department of Pharmacology, Hoffmann La-Roche, Inc., Nutley, NJ
,
Janet E. Schwarz Department of Pathology, College of Medicine, University of Vermont, Burlington, Nutley, NJ; Department of Pharmacology, Hoffmann La-Roche, Inc., Nutley, NJ
,
Wayne H. Anderson Department of Pathology, College of Medicine, University of Vermont, Burlington, Nutley, NJ; Department of Pharmacology, Hoffmann La-Roche, Inc., Nutley, NJ
&
Ann F. Welton Department of Pathology, College of Medicine, University of Vermont, Burlington, Nutley, NJ; Department of Pharmacology, Hoffmann La-Roche, Inc., Nutley, NJ
Pages 25-43 | Received 13 May 1986, Accepted 28 Sep 1986, Published online: 02 Jul 2009

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Jizhen Lin, Youngki Kim, Christopher Lees & Steven K. Juhn. (1996) Effects of Platelet-Activating Factor (PAF) Receptor Blockage on Mucous Glycoprotein Secretion in Cultured Chinchilla Middle Ear Epithelium. Acta Oto-Laryngologica 116:1, pages 69-73.
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Thomas L Benfield & Jens D Lundgren. (1994) PAF receptor antagonists in the treatment of asthma. Expert Opinion on Investigational Drugs 3:7, pages 733-742.
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John R. Dodam, Neil C. Olson & Mitchell Friedman. (1994) Differential Effects of Tumor Necrosis Factor-α and Platelet-Activating Factor on Bovine Pulmonary Artery Endothelial Cells in Vitro. Experimental Lung Research 20:2, pages 131-141.
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Jon A. Hotchkiss, Michelle A. Stam & Jack R. Harkema. (1993) Platelet Activating Factor Stimulates Rapid Mucin Secretion in Rat Nasal Airways In Vivo. Experimental Lung Research 19:5, pages 545-557.
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Leah A. Cohn & Kenneth B. Adler. (1992) Interactions Between Airway Epithelium and Mediators of Inflammation. Experimental Lung Research 18:3, pages 299-322.
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Tong Wu, Jens D. Lundgren, R. Dwaine Rieves, Martin E. Doerfler, Carolea Logun & James H. Shelhamer. (1991) Platelet-Activating Factor Stimulates Eicosanoid Production in Cultured Feline Tracheal Explants. Experimental Lung Research 17:6, pages 1079-1094.
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K. Chul Kim. (1991) Biochemistry and Pharmacology of Mucin-like Glycoproteins Produced by Cultured Airway Epithelial Cells. Experimental Lung Research 17:3, pages 533-545.
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Stephen E. Alpert, Constance M. Kramer, John R. Brashler & Michael K. Bach. (1990) Generation of Lipoxygenase Metabolites of Arachidonic Acid by Monolayer Cultures of Tracheal Epithelial Cells and Intact Tracheal Segments from Rabbits. Experimental Lung Research 16:3, pages 211-233.
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S. T. Hoffstein, P. E. Malo, P. Bugelski & E. B. Wheeldon. (1990) Leukotriene D4 (LTD4) Induces Mucus Secretion from Goblet Cells in the Guinea Pig Respiratory Epithelium. Experimental Lung Research 16:6, pages 711-725.
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Articles from other publishers (31)

Kurt H. Albertine. 2016. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 3 21.e5 .
Jonathan H. Widdicombe & Jeffrey J. Wine. (2015) Airway Gland Structure and Function. Physiological Reviews 95:4, pages 1241-1319.
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Mark T. Whary. 2014. Biology and Diseases of the Ferret. Biology and Diseases of the Ferret 81 122 .
Suresh Pavuluri, Veronica Hanus & Dale R. Bergren. (2013) Interaction of tobacco smoke exposure and ovalbumin-sensitization promotes goblet cell and submucosal gland metaplasia in guinea pigs. Respiratory Physiology & Neurobiology 189:3, pages 639-645.
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Kurt H. Albertine. 2010. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 3 25 .
Judith A. Voynow & Bruce K. Rubin. (2009) Mucins, Mucus, and Sputum. Chest 135:2, pages 505-512.
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Rene Schmidt, Petra Staats, David A Groneberg & Ulrich Wagner. (2008) Effect of montelukast on platelet activating factor- and tachykinin induced mucus secretion in the rat. Journal of Occupational Medicine and Toxicology 3:1.
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J Widdicombe. 2004. Therapy for Mucus-Clearance Disorders. Therapy for Mucus-Clearance Disorders 43 85 .
Kenneth B. Adler & Yuehua Li. (2001) Airway Epithelium and Mucus. American Journal of Respiratory Cell and Molecular Biology 25:4, pages 397-400.
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William R. HendersonJr.Jr., Jiangyang Lu, Karen M. Poole, Gregory N. Dietsch & Emil Y. Chi. (2000) Recombinant Human Platelet-Activating Factor- Acetylhydrolase Inhibits Airway Inflammation and Hyperreactivity in Mouse Asthma Model. The Journal of Immunology 164:6, pages 3360-3367.
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G. SCOTT GIEBINK. (1999) Otitis Media: The Chinchilla Model1. Microbial Drug Resistance 5:1, pages 57-72.
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C. William Davis. 1997. Airway Mucus: Basic Mechanisms and Clinical Perspectives. Airway Mucus: Basic Mechanisms and Clinical Perspectives 149 177 .
Jizhen Lin, Youngki Kim, Frank Ondrey, Chris Lees & Steven K. Juhn. (2016) Effect of Lipoxygenase Inhibition on Mucous Glycoprotein Secretion from Chinchilla Middle Ear Fpithelial Cells in Vitro. Annals of Otology, Rhinology & Laryngology 105:11, pages 916-921.
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Lori G. Rochelle, Bernard M. Fischer, Thomas M. Krunkosky, David T. Wright & Kenneth B. Adler. (1996) Environmental Toxins Induce Intracellular Responses of Airway Epithelium Through Reactive Species of Oxygen and Nitrogen. Chest 109:3, pages 35S-39S.
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T. Wu, R. D. Rieves, C. Logun & J. H. Shelhamer. (1995) Platelet-activating factor stimulates eicosanoid production in cultured feline tracheal epithelial cells. Lung 173:2, pages 89-103.
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Kenneth B. Adler, Bernard M. Fischer, David T. Wright, Leah A. Cohn & Susanne Becker. (1994) Interactions between Respiratory Epithelial Cells and Cytokines: Relationships to Lung Inflammation. Annals of the New York Academy of Sciences 725:1, pages 128-145.
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G. Stewart. 1994. Lipid Mediators. Lipid Mediators 221 295 .
Dom Spina. 1994. Airways Smooth Muscle: Development, and Regulation of Contractility. Airways Smooth Muscle: Development, and Regulation of Contractility 259 289 .
Duncan F. Rogers. 1994. Airways Smooth Muscle: Development, and Regulation of Contractility. Airways Smooth Muscle: Development, and Regulation of Contractility 375 409 .
Michael I. Lethem. (1993) The role of tracheobronchial mucus in drug administration to the airways. Advanced Drug Delivery Reviews 11:3, pages 271-298.
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J.D. Lundgren & J.N. Baraniuk. (1992) Mucus secretion and inflammation. Pulmonary Pharmacology 5:2, pages 81-96.
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Kenneth B. Adler, Nancy J. Akley & Wayne C. Glasgow. (1992) Platelet-activating Factor Provokes Release of Mucin-like Glycoproteins from Guinea Pig Respiratory Epithelial Cells via a Lipoxygenase-dependent Mechanism. American Journal of Respiratory Cell and Molecular Biology 6:5, pages 550-556.
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R. Dwaine Rieves, Julie Goff, Tong Wu, Pierre Larivee, Carolea Logun & James H. Shelhamer. (1992) Airway Epithelial Cell Mucin Release: Immunologic Quantitation and Response to Platelet-activating Factor. American Journal of Respiratory Cell and Molecular Biology 6:2, pages 158-167.
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Arvind K. Virmani, Bashoo Naziruddin, Vinay C. Desai, Jon P. Lowry, Donald C. Graves & Goverdhan P. Sachdev. (1992) Evidence for secretion of high molecular weight mucins by canine tracheal epithelial cells in primary culture: Effects of select secretagogues on mucin secretion. In Vitro Cellular & Developmental Biology - Animal 28:2, pages 120-127.
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Jun Tamaoki, Noritaka Sakai, Kazuo Isono, Toshinori Kanemura, Isao Yamawaki & Takao Takizawa. (1991) Effects of platelet-activating factor on bioelectric properties of cultured tracheal and bronchial epithelia. Journal of Allergy and Clinical Immunology 87:6, pages 1042-1049.
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P. J. Barnes, K. F. Chung & C. P. Page. 1991. Pharmacology of Asthma. Pharmacology of Asthma 53 106 .
Adam Wanner. (1990) Utility of Animal Models in the Study of Human Airway Disease. Chest 98:1, pages 211-217.
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J. D. Lundgren, M. Kaliner, C. Logun & J. H. Shelhamer. (1990) Platelet activating factor and tracheobronchial respiratory glycoconjugate release in feline and human explants: Involvement of the lipoxygenase pathway. Agents and Actions 30:3-4, pages 329-337.
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Jens D. Lundgren & James H. Shelhamer. (1990) Pathogenesis of airway mucus hypersecretion. Journal of Allergy and Clinical Immunology 85:2, pages 399-417.
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Kwang C. Kim, Javid Nassiri & Jerome S. Brody. (1989) Mechanisms of Airway Goblet Cell Mucin Release: Studies with Cultured Tracheal Surface Epithelial Cells. American Journal of Respiratory Cell and Molecular Biology 1:2, pages 137-143.
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Linda M. McManus & Stephanie I. Deavers. (1989) Platelet Activating Factor in Pulmonary Pathobiology. Clinics in Chest Medicine 10:1, pages 107-118.
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