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Experimental Lung Research Volume 13, 1987 - Issue 3
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Original Article

An Ultrastructural Study of the Response of Hamster Bronchial Epithelium to Human Neutrophil Elastase

T. G. Christensen Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
,
R. Breuer Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
,
L. J. Hornstra Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
,
E. C. Lucey Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
,
P. J. Stone Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
&
G. L. Snider Pulmonary Center and the Departments of Pathology and Biochemistry, Boston University School of Medicine, Boston, MA; Mallory Institute of Pathology, the Boston Veterans Administration Medical Center, Boston, MA; Pulmonary Division, Hadassah University Hospital, Jerusalem, Israel
Pages 279-297 | Received 04 Aug 1986, Accepted 01 Feb 1987, Published online: 02 Jul 2009

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Kristen J. Nikula & Francis H. Y. Green. (2000) ANIMAL MODELS OF CHRONIC BRONCHITIS AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE. Inhalation Toxicology 12:sup4, pages 123-153.
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S. Jamil, R. Breuer & T. G. Christensen. (1997) Abnormal Mucous Cell Phenotype Induced by Neutrophil Elastase in Hamster Bronchi. Experimental Lung Research 23:4, pages 285-295.
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R. Breuer, T. G. Christensen, E. C. Lucey, G. Bolbochan, P. J. Stone & G. L. Snider. (1993) Elastase Causes Secretory Discharge in Bronchi of Hamsters with Elastase-Induced Secretory Cell Metaplasia. Experimental Lung Research 19:2, pages 273-282.
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V. K. Dimitriadis, T. G. Christensen, E. C. Lucey, G. L. Snider & C. G. Plopper. (1992) Changes in the Carbohydrate Content of Airway Epithelium Induced by Human Neutrophil Elastase in the Hamster. Experimental Lung Research 18:5, pages 731-742.
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Thomas G. Christensen, Raphael Breuer, Christopher E. Haddad, Edgar C. Lucey, Phillip J. Stone & Gordon L. Snider. (1992) Resistance of Hamster Bronchiolar Epithelium to Neutrophil Elastase: Investigation by Cell Surface Lectin Cytochemistry. Experimental Lung Research 18:1, pages 115-129.
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Thomas G. Christensen, Raphael Breuer, Edgar C. Lucey, Phillip J. Stone & Gordon L. Snider. (1989) Regional Difference in Airway Epithelial Response to Neutrophil Elastase: Tracheal Secretory Cells Discharge and Recover in Hamsters That Develop Bronchial Secretory-Cell Metaplasia. Experimental Lung Research 15:6, pages 943-959.
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E. C. Lucey, P. J. Stone, T. G. Christensen, R. Breuer & G. L. Snider. (1988) An 18-Month Study of the Effects on Hamster Lungs of Intratracheally Administered Human Neutrophil Elastase. Experimental Lung Research 14:5, pages 671-686.
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T. G. Christensen, R. Breuer, L. J. Hornstra, E. C. Lucey & G. L. Snider. (1987) The Ultrastructure of Hamster Bronchial Epithelium. Experimental Lung Research 13:3, pages 253-277.
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Charles G. Plopper & Dallas M. Hyde. 2015. Comparative Biology of the Normal Lung. Comparative Biology of the Normal Lung 83 92 .
Steven R. Hays & John V. Fahy. (2006) Characterizing Mucous Cell Remodeling in Cystic Fibrosis. American Journal of Respiratory and Critical Care Medicine 174:9, pages 1018-1024.
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H. Komatsu, S. Yamaguchi, N. Komorita, K. Goto, S. Takagi, H. Ochi & T. Okumoto. (2005) Inhibition of endotoxin- and antigen-induced airway inflammation by fudosteine, a mucoactive agent. Pulmonary Pharmacology & Therapeutics 18:2, pages 121-127.
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Duncan F. Rogers. (2005) Mucociliary dysfunction in COPD: effect of current pharmacotherapeutic options. Pulmonary Pharmacology & Therapeutics 18:1, pages 1-8.
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Markus O. Henke, Armin Renner, Rudolf M. Huber, Michael C. Seeds & Bruce K. Rubin. (2004) MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions. American Journal of Respiratory Cell and Molecular Biology 31:1, pages 86-91.
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Bernard M. Fischer, Jacob G. Cuellar, Meredith L. Diehl, Akira M. deFreytas, Jin Zhang, Kermit L. Carraway & Judith A. Voynow. (2003) Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 284:4, pages L671-L679.
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Bernard M. Fischer & Judith A. Voynow. (2002) Neutrophil Elastase Induces MUC 5AC Gene Expression in Airway Epithelium via a Pathway Involving Reactive Oxygen Species . American Journal of Respiratory Cell and Molecular Biology 26:4, pages 447-452.
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E. M. App, R. Bals, J. Behr, G. Döring, M. Griese, H. Lindemann, A. Schuster & C. Vogelmeier. 2001. Cystische Fibrose. Cystische Fibrose 121 184 .
Peter Greaves. 2000. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 203 253 .
Gerd Döring. (1999) Serine proteinase inhibitor therapy in α 1 ‐antitrypsin inhibitor deficiency and cystic fibrosis . Pediatric Pulmonology 28:5, pages 363-375.
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Judith A. Voynow, Lisa Rosenthal Young, Yiqiong Wang, Teresa Horger, Mary C. Rose & Bernard M. Fischer. (1999) Neutrophil elastase increases MUC5AC mRNA and protein expression in respiratory epithelial cells . American Journal of Physiology-Lung Cellular and Molecular Physiology 276:5, pages L835-L843.
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Dechun Li & Peter K. Jeffery. 1997. Airway Mucus: Basic Mechanisms and Clinical Perspectives. Airway Mucus: Basic Mechanisms and Clinical Perspectives 227 273 .
Stephen I. Rennard. (1996) Repair mechanisms in asthma. Journal of Allergy and Clinical Immunology 98:6, pages S278-S286.
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Sabine Rehm. 1996. Respiratory System. Respiratory System 158 173 .
Sabine Rehm, William Lijinsky, Barbara J. Thomas & Barbara H. Kasprzak. (1993) Clara cell antigen in normal and migratory dysplastic Clara cells, and bronchioloalveolar carcinoma of Syrian hamsters induced by N-nitrosomethyl-n-heptylamine. Virchows Archiv B Cell Pathology Including Molecular Pathology 64:1, pages 181-190.
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R. Breuer, T. G. Christensen, Y. Wax, G. Bolbochan, E. C. Lucey, P. J. Stone & G. L. Snider. (1993) Relationship of Secretory Granule Content and Proliferative Intensity in the Secretory Compartment of the Hamster Bronchial Epithelium. American Journal of Respiratory Cell and Molecular Biology 8:5, pages 480-485.
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C.G. PLOPPER. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 1 24 .
Gordon L. Snider. (1992) Animal Models of Chronic Airways Injury. Chest 101:3, pages 74S-79S.
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M FroscoC FahedT ChaseJrJrJ D Macmillan. (1992) Inhibition of Aspergillus fumigatus elastase with monoclonal antibodies produced by using denatured elastase as an immunogen. Infection and Immunity 60:3, pages 735-741.
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H.M. Nields, G.L. Snider, R. Breuer & Th. Christensen. (1991) Reversible pancreatic elastase-induced bronchial secretory cell metaplasia in the rat. Experimental pathology 41:4, pages 185-193.
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Elizabeth M. McDowell, Andrea M. DeSanti, Carnell Newkirk & Judy M. Strum. (1990) Effects of vitamin A-deficiency and inflammation on the conducting airway epithelium of Syrian golden hamsters. Virchows Archiv B Cell Pathology Including Molecular Pathology 59:1, pages 231-242.
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Thomas G. Christensen, Raphael Breuer, Edgar C. Lucey, Linda J. Hornstra, Phillip J. Stone & Gordon L. Snider. (1990) Lectin Cytochemistry Reveals Differences between Hamster Trachea and Bronchus in the Composition of Epithelial Surface Glycoconjugates and in the Response of Secretory Cells to Neutrophil Elastase. American Journal of Respiratory Cell and Molecular Biology 3:1, pages 61-69.
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Adam Wanner. (1990) The Role of Mucus in Chronic Obstructive Pulmonary Disease. Chest 97:2, pages 11s-15s.
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T.G. Christensen, E.C. Lucey, R. Breuer & G.L. Snider. (1988) Acid-induced secretory cell metaplasia in hamster bronchi. Environmental Research 45:1, pages 78-90.
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