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Experimental Lung Research Volume 14, 1988 - Issue 1
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Original Article

Transition from Normal to Hypersecretory Bronchial Mucus in a Canine Model of Bronchitis: Changes in Yield and Composition

K. Ramakrishnan Bhaskar Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, 02115; Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, Massachusetts, 02115; Departments of Medicine, Beth Israel Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115
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Jeffrey M. Drazen Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, 02115; Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, Massachusetts, 02115; Departments of Medicine, Beth Israel Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115
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Donna Defeudis O'sullivan Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, 02115; Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, Massachusetts, 02115; Departments of Medicine, Beth Israel Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115
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Paul M. Scanlon Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, 02115; Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, Massachusetts, 02115; Departments of Medicine, Beth Israel Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115
&
Lynne M. Reid Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts, 02115; Department of Environmental Science and Physiology, Harvard School of Public Health, Boston, Massachusetts, 02115; Departments of Medicine, Beth Israel Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, 02115
Pages 101-120 | Received 25 Nov 1986, Accepted 11 Apr 1987, Published online: 02 Jul 2009

Citations (17)

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S. Jamil, R. Breuer & T. G. Christensen. (1997) Abnormal Mucous Cell Phenotype Induced by Neutrophil Elastase in Hamster Bronchi. Experimental Lung Research 23:4, pages 285-295.
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Richard B. Schlesinger. (1990) The Interaction of Inhaled Toxicants with Respiratory Tract Clearance Mechanisms. Critical Reviews in Toxicology 20:4, pages 257-286.
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Helen Opaskar Hincman, K. Ramakrishnan Bhaskar, Donna Defeudis O'sullivan, Robert Brown & Lynne Reid. (1990) Lipids in Airway Mucus of Acute Quadriplegic Patients. Experimental Lung Research 16:4, pages 369-385.
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K. Chul Kim & B. N. Singh. (1990) Hydrophobicity of Mucin-Like Glycoproteins Secreted by Cultured Tracheal Epithelial Cells: Association with Lipids. Experimental Lung Research 16:3, pages 279-292.
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Kwang C. Kim, Helen Opaskar-Hincman & K. Ramakrishnan Bhaskar. (1989) Secretions from Primary Hamster Tracheal Surface Epithelial Cells in Culture: Mucin-Like Glycoproteins, Proteoglycans, and Lipids. Experimental Lung Research 15:2, pages 299-314.
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Articles from other publishers (12)

Eleanor C. Hawkins, Adam J. Birkenheuer, Henry S. Marr, Allison R. Rogala, Edward E. Large & Kenneth B. Adler. (2007) Quantification of mucin gene expression in tracheobronchial epithelium of healthy dogs and dogs with chronic bronchitis. American Journal of Veterinary Research 68:4, pages 435-440.
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Stephanie A. Shore. 2002. Asthma and COPD. Asthma and COPD 79 88 .
J. M. Drazen, T. Takebayashi, N. C. Long, G. T. DE Sanctis & S. A. Shore. (1999) Animal models of asthma and chronic bronchitis. Clinical & Experimental Allergy 29, pages 37-47.
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Chikako Kishioka, Takeshi Shimizu, Kenichiro Fujita, Yasuhiko Ito, Yuichi Majima & Yasuo Sakakura. (2018) Monoclonal Antibody-Detectable Carbohydrate Epitopes of Human Nasal Secretions are Differentially Expressed in Tissue and Diseases. American Journal of Rhinology 13:1, pages 37-43.
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David C. Underwood. 1999. In Vivo Models of Inflammation. In Vivo Models of Inflammation 159 177 .
David E. Sims & Margaret M. Horne. (1997) Heterogeneity of the composition and thickness of tracheal mucus in rats. American Journal of Physiology-Lung Cellular and Molecular Physiology 273:5, pages L1036-L1041.
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Edward M. Postlethwait, Shannon D. Langford, Lydia M. Jacobson & Akhil Bidani. (1995) NO2 reactive absorption substrates in rat pulmonary surface lining fluids. Free Radical Biology and Medicine 19:5, pages 553-563.
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Robert P. Tomkiewicz, Gary M. Albers, Oscar E. Ramirez, Bruce K. Rubin, George T. De Sanctis & Malcolm King. (1995) Species differences in the physical and transport properties of airway secretions. Canadian Journal of Physiology and Pharmacology 73:2, pages 165-171.
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Berthold Jany, Marianne Gallup, Tohru Tsuda & Carol Basbaum. (1991) Mucin gene expression in rat airways following infection and irritation. Biochemical and Biophysical Research Communications 181:1, pages 1-8.
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Berthold Jany & Carol B. Basbaum. (1991) Modification of Mucin Gene Expression in Airway Disease. American Review of Respiratory Disease 144:3_pt_2, pages S38-S41.
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K. Ramakrishnan Bhaskar, Robert Brown, Donna Defeudis O'Sullivan, Stephen Melia, Marie Duggan & Lynne Reid. (1991) Bronchial Mucus Hypersecretion in Acute Quadriplegia: Macromolecular Yields and Glycoconjugate Composition. American Review of Respiratory Disease 143:3, pages 640-648.
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Takeshi Koshino, K. Ramakrishnan Bhaskar, Lynne M. Reid, Craig Gerard, Angeline Warner, Stephanie A. Shore, Kristin Anderson, Greg Butler, Hideya Iijima & Jeffrey M. Drazen. (1990) Recovery of an Epitope Recognized by a Novel Monoclonal Antibody from Airway Lavage during Experimental Induction of Chronic Bronchitis. American Journal of Respiratory Cell and Molecular Biology 2:5, pages 453-462.
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