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Original Article

The Beige Mouse: Role of Neutrophil Elastase in the Development of Pulmonary Emphysema

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Pages 785-800 | Received 09 Nov 1988, Accepted 19 Apr 1989, Published online: 02 Jul 2009

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Monica Yonashiro Marcelino, Natalia Langenfeld Fuoco, Carolina Arruda de Faria, Rodrigo de Las Heras Kozma, Lais Fernanda Marques & João Tadeu Ribeiro-Paes. (2014) Animal models in chronic obstructive pulmonary disease—an overview. Experimental Lung Research 40:6, pages 259-271.
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Thomas H. March, Francis H. Y. Green, Fletcher F. Hahn & Kristen J. Nikula. (2000) ANIMAL MODELS OF EMPHYSEMA AND THEIR RELEVANCE TO STUDIES OF PARTICLE-INDUCED DISEASE. Inhalation Toxicology 12:sup4, pages 155-187.
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Velin Dominique & Loor Francis. (1995) Interactions of the Scid or Beige Mutations with the Viable Motheaten Mutation. Autoimmunity 22:4, pages 199-207.
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Yih-Loong Lai & Louis Diamond. (1990) Inhibition of Porcine Pancreatic Elastase-Induced Emphysema by Eglin-c. Experimental Lung Research 16:5, pages 547-557.
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Sandra Pérez-Rial, Álvaro Girón-Martínez & Germán Peces-Barba. (2015) Modelos animales de enfermedad pulmonar obstructiva crónica. Archivos de Bronconeumología 51:3, pages 121-127.
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J. Craig Fox & Mary F. Fitzgerald. (2004) Models of chronic obstructive pulmonary disease: a review of current status. Drug Discovery Today: Disease Models 1:3, pages 319-328.
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Kang-Hyeon Choe, Laimute Taraseviciene-Stewart, Robertas Scerbavicius, Lajos Gera, Rubin M. Tuder & Norbert F. Voelkel. (2003) Methylprednisolone Causes Matrix Metalloproteinase–dependent Emphysema in Adult Rats. American Journal of Respiratory and Critical Care Medicine 167:11, pages 1516-1521.
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Juanita H. J. Vernooy, Mieke A. Dentener, Robert J. van Suylen, Wim A. Buurman & Emiel F. M. Wouters. (2002) Long-Term Intratracheal Lipopolysaccharide Exposure in Mice Results in Chronic Lung Inflammation and Persistent Pathology. American Journal of Respiratory Cell and Molecular Biology 26:1, pages 152-159.
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E. Cavarra, P.A. Martorana, B. Bartalesi, S. Fineschi, F. Gambelli, M. Lucattelli, L. Ortiz & G. Lungarella. (2001) Genetic deficiency of α 1 ‐PI in mice influences lung responses to bleomycin . European Respiratory Journal 17:3, pages 474-480.
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GORDANA VLAHOVIC, MICHAEL L. RUSSELL, ROBERT R. MERCER & JAMES D. CRAPO. (1999) Cellular and Connective Tissue Changes in Alveolar Septal Walls in Emphysema. American Journal of Respiratory and Critical Care Medicine 160:6, pages 2086-2092.
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Mary Dolores O'Donnell, Clare Marie O'Connor, Muiris Xavier FitzGerald, Giuseppe Lungarella, Eleonora Cavarra & Piero A Martorana. (1999) Ultrastructure of lung elastin and collagen in mouse models of spontaneous emphysema. Matrix Biology 18:4, pages 357-360.
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Eleonora Cavarra, Piero A. Martorana, Margherita de Santi, Barbara Bartalesi, Simone Cortese, Federica Gambelli & Giuseppe Lungarella. (1999) Neutrophil Influx into the Lungs of Beige Mice Is Followed by Elastolytic Damage and Emphysema. American Journal of Respiratory Cell and Molecular Biology 20:2, pages 264-269.
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Giuseppe Lungarella, Eleonora Cavarra & Piero A. Martorana. 1999. Molecular Biology of the Lung. Molecular Biology of the Lung 19 36 .
Eleonora Cavarra, Piero A. Martorana, Simone Cortese, Federica Gambelli, Paolo Di Simplicio & Giuseppe Lungarella. (1997) Neutrophils in Beige Mice Secrete Normal Amounts of Cathepsin G and a 46 kDa Latent Form of Elastase that Can Be Activated Extracellularly by Proteolytic Activity. Biological Chemistry 378:5.
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Toyohiro Hirai, Masanori Hosokawa, Kenzo Kawakami, Yasutaka Takubo, Naoki Sakai, Yoshitaka Oku, Kazuo Chin, Motoharu Ohi, Keiichi Higuchi, Kenshi Kuno & Michiaki Mishima. (1995) Age-related changes in the static and dynamic mechanical properties of mouse lungs. Respiration Physiology 102:2-3, pages 195-203.
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Gordon L. Snider, Edgar C. Lucey & Phillip J. Stone. (1994) Pitfalls in Antiprotease Therapy of Emphysema. American Journal of Respiratory and Critical Care Medicine 150:6_pt_2, pages S131-S137.
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Arjan Rudolphus, Jan Stolk, Joop H. Dijkman & Johannes A. Kramps. (1993) Inhibition of Lipopolysaccharide-induced Pulmonary Emphysema by Intratracheally Instilled Recombinant Secretory Leukocyte Proteinase Inhibitor. American Review of Respiratory Disease 147:2, pages 442-447.
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Jan Stolk, Arjan Rudolphus, Philip Davies, Don Osinga, Joop H. Dijkman, Lilly Agarwal, Kevin P. Keenan, Dan Fletcher & Johannes A. Kramps. (2005) Induction of emphysema and bronchial mucus cell hyperplasia by intratracheal instillation of lipopolysaccharide in the hamster. The Journal of Pathology 167:3, pages 349-356.
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PHILIP DAVIES, B. M. ASHE, R. J. BONNEY, C. DORN, P. FINKE, D. FLETCHER, W. A. HANLON, J. L. HUMES, A. MAYCOCK, R. A. MUMFORD, M. A. NAVIA, E. E. OPAS, S. PACHOLOK, S. SHAH, M. ZIMMERMAN & J. B. DOHERTY. (1991) The Discovery and Biologic Properties of Cephalosporin-Based Inhibitors of PMN Elastase. Annals of the New York Academy of Sciences 624:1, pages 219-229.
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J. A. KRAMPS, A. RUDOLPHUS, J. STOLK, L. N. A. WILLEMS & J. H. DIJKMAN. (1991) Role of Antileukoprotease in the Human Lung. Annals of the New York Academy of Sciences 624:1, pages 97-108.
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A. Shock & G.J. Laurent. (1990) Leucocytes and pulmonary disorders: Mobilization, activation and role in pathology. Molecular Aspects of Medicine 11:6, pages 425-526.
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