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Original Article

Response of Rat Alveolar Macrophages to Ozone: Quantitative Assessment of Population Size, Morphology, and Proliferation following Acute Exposure

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Pages 1-16 | Received 04 Oct 1987, Accepted 22 Feb 1988, Published online: 02 Jul 2009

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Gautam Damera, William F. Jester, Meiqi Jiang, Hengjiang Zhao, Homer W. Fogle, Michael Mittelman, Angela Haczku, Edwin Murphy, Indu Parikh & Reynold A. Panettieri$suffix/text()$suffix/text(). (2010) Inhibition of myristoylated alanine-rich C kinase substrate (MARCKS) protein inhibits ozone-induced airway neutrophilia and inflammation. Experimental Lung Research 36:2, pages 75-84.
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G. Lacroix, S. Tissot, F. Rogerieux, R. Beaulieu, L. Cornu, C. Gillet, F. Robidel, J. P. Lefèvre & F. Y. Bois. (2002) DECREASE IN OVALBUMIN-INDUCED PULMONARY ALLERGIC RESPONSE BY BENZALDEHYDE BUT NOT ACETALDEHYDE EXPOSURE IN A GUINEA PIG MODEL. Journal of Toxicology and Environmental Health, Part A 65:14, pages 995-1012.
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H. Van Loveren, P. J. A. Rombout, P. H. Fischer, E. Lebret & L. Van Bree. (1995) Modulation Of Host Defenses By Exposure To Oxidant Air Pollutants. Inhalation Toxicology 7:3, pages 405-423.
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Kenneth Donaldson, Geraldine M. Brown, David M. Brown, Joan Slight, William Maclaren & John M. G. Davis. (1993) Characteristics of Bronchoalveolar Leukocytes from the Lungs of Rats Inhaling 0.2–0.8 ppm OF Ozone. Inhalation Toxicology 5:1, pages 149-164.
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Ronald E. Rasmussen. (1992) Effects of Acute no, Exposure in the Weanling Ferret Lung. Inhalation Toxicology 4:4, pages 373-382.
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J. A. Hotchkiss, J. R. Harkema & R. F. Henderson. (1991) Effect of Cumulative Ozone Exposure on Ozone-Induced Nasal Epithelial Hyperplasia and Secretory Metaplasia in Rats. Experimental Lung Research 17:3, pages 589-600.
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Matthew I. Gilmour, Robert R. Hmieleski, Elizabeth A. Stafford & George J. Jakab. (1991) Suppression and Recovery of the Alveolar Macrophage Phagocytic System during Continuous Exposure to 0.5 ppm Ozone. Experimental Lung Research 17:3, pages 547-558.
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J. A. M. A. Dormans, P. J. A. Rombout & H. Van Loveren. (1990) Surface morphology and morphometry of rat alveolar macrophages after ozone exposure. Journal of Toxicology and Environmental Health 31:1, pages 53-70.
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Articles from other publishers (26)

Gregory J. Smith, Adelaide Tovar, Matt Kanke, Yong Wang, Jessy S. Deshane, Praveen Sethupathy & Samir N. P. Kelada. (2021) Ozone‐induced changes in the murine lung extracellular vesicle small RNA landscape. Physiological Reports 9:18.
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Jennifer Tegtmeier, Marcel Brosch, Kathrin Janitzky, Hans-Jochen Heinze, Frank W. Ohl & Michael T. Lippert. (2018) CAVE: An Open-Source Tool for Combined Analysis of Head-Mounted Calcium Imaging and Behavior in MATLAB. Frontiers in Neuroscience 12.
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Brita Kilburg-Basnyat, Sky W Reece, Miranda J Crouch, Bin Luo, Andria D Boone, Michael Yaeger, Myles Hodge, Christine Psaltis, Johanna L Hannan, Jonathan Manke, Michael L Armstrong, Nichole Reisdorph, Robert M Tighe, Saame Raza Shaikh & Kymberly M Gowdy. (2018) Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation. Toxicological Sciences 163:2, pages 466-477.
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Karin A. Zemski Berry & Robert C. Murphy. (2016) Phospholipid Ozonation Products Activate the 5-Lipoxygenase Pathway in Macrophages. Chemical Research in Toxicology 29:8, pages 1355-1364.
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Zhuowei Li, Robert M. Tighe, Feifei Feng, Julie G. Ledford & John W. Hollingsworth. (2013) Genes of Innate Immunity and the Biological Response to Inhaled Ozone. Journal of Biochemical and Molecular Toxicology 27:1, pages 3-16.
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Robert M. Tighe, Zhuowei Li, Erin N. Potts, Sarah Frush, Ningshan Liu, Michael D. Gunn, W. Michael Foster, Paul W. Noble & John W. Hollingsworth. (2011) Ozone Inhalation Promotes CX3CR1-Dependent Maturation of Resident Lung Macrophages That Limit Oxidative Stress and Inflammation. The Journal of Immunology 187:9, pages 4800-4808.
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Paul M. O'Byrne, Mark D. Inman & Donald M. McDonald. 2005. Mucosal Immunology. Mucosal Immunology 1403 1414 .
Eliezer Bermúdez, Shiaw-Fen Ferng, C.Elizabeth Castro & Mohammad G. Mustafa. (1999) DNA Strand Breaks Caused by Exposure to Ozone and Nitrogen Dioxide. Environmental Research 81:1, pages 72-80.
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Svetlana Prokhorova, Naimish Patel & Debra L. Laskin. (1998) Regulation of alveolar macrophage and type II cell DNA synthesis: effects of ozone inhalation. American Journal of Physiology-Lung Cellular and Molecular Physiology 275:6, pages L1200-L1207.
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Ron A. Herbert, James R. Hailey, Sondra Grumbein, Billy J. Chou, Robert C. Sills, Joseph K. Haseman, Thomas Goehl, Rodney A. Miller, Joseph H. Roycroft & Gary A. Boorman. (2016) Two-Year and Lifetime Toxicity and Carcinogenicity Studies of Ozone in B6C3F1 Mice. Toxicologic Pathology 24:5, pages 539-548.
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Wil H. M. Stevens & Paul M. O’Byrne. 1996. Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo. Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo 95 119 .
K. Sahu & R.K. Das. (1995) Micronucleus assay in pulmonary alveolar macrophages, a simple model to detect genotoxicity of environmental agents entering through the inhalation route. Mutation Research Letters 347:2, pages 61-65.
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R.K. Das, K. Sahu & B.C. Dash. (1994) Induction of chromosome aberrations and micronuclei in pulmonary alveolar macrophages of rats following inhalation of mosquito coil smoke. Mutation Research/Genetic Toxicology 320:4, pages 285-292.
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K.J. Pendino, C.R. Gardner, J.D. Laskin & D.L. Laskin. (1993) Induction of functionally active platelet-activating factor receptors in rat alveolar macrophages.. Journal of Biological Chemistry 268:26, pages 19165-19168.
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B. Nemery & P.H.M. Hoet. (1993) Use of isolated lung cells in pulmonary toxicology. Toxicology in Vitro 7:4, pages 359-364.
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Katarina Victorin. (1992) Review of the genotoxicity of ozone. Mutation Research/Reviews in Genetic Toxicology 277:3, pages 221-238.
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P FritschR Masse. (1992) Overview of pulmonary alveolar macrophage renewal in normal rats and during different pathological processes.. Environmental Health Perspectives 97, pages 59-67.
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D.S. Boehme, J.A. Hotchkiss & R.F. Henderson. (1992) Glutathione and GSH-dependent enzymes in bronchoalveolar lavage fluid cells in response to ozone. Experimental and Molecular Pathology 56:1, pages 37-48.
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Ronald S. Oosting, Lambert M.G. van Golde, Jan Verhoef & Leendert van Bree. (1991) Species differences in impairment and recovery of alveolar macrophage functions following single and repeated ozone exposures. Toxicology and Applied Pharmacology 110:1, pages 170-178.
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P. J. Haley, B. A. Muggenburg, D. N. Weissman & D. E. Bice. (2005) Comparative morphology and morphometry of alveolar macrophages from six species. American Journal of Anatomy 191:4, pages 401-407.
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David Gordon & Stephen M. Schwartz. (1991) Cell proliferation in human atherosclerosis. Trends in Cardiovascular Medicine 1:1, pages 24-28.
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Mary E. Brandes & Jacob N. Finkelstein. (1990) The production of alveolar macrophage-derived growth-regulating proteins in response to lung injury. Toxicology Letters 54:1, pages 3-22.
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K. Rithidech, J.A. Hotchkiss, W.C. Griffith, R.F. Henderson & A.L. Brooks. (1990) Chromosome damage in rat pulmonary alveolar macrophages following ozone inhalation. Mutation Research/Genetic Toxicology 241:1, pages 67-73.
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Elaine S. Wright, Daniel Dziedzic & Candace S. Wheeler. (1990) Cellular, biochemical and functional effects of ozone: new research and perspectives on ozone health effects. Toxicology Letters 51:2, pages 125-145.
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Takamichi Ichinose & Masaru Sagai. (1989) Biochemical effects of combined gases of nitrogen dioxide and ozone III. Synergistic effects on lipid peroxidation and antioxidative protective systems in the lungs of rats and guinea pigs. Toxicology 59:3, pages 259-270.
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Jon A. Hotchkiss, Jack R. Harkema, James D. Sun & Rogene F. Henderson. (1989) Comparison of acute ozone-induced nasal and pulmonary inflammatory responses in rats. Toxicology and Applied Pharmacology 98:2, pages 289-302.
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