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Original Article

In Vivo Effects of Endotoxin on Nasal Epithelial Mucosubstances: Quantitative Histochemistry

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Pages 743-761 | Received 29 May 1990, Accepted 28 Aug 1990, Published online: 02 Jul 2009

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Morris B. Snipes, Jack R. Harkema, Jon A. Hotchkiss & David E. Bice. (1997) Neutrophil Involvement in the Retention and Clearance of Dust Intratracheally Instilled into the LUNGS of F344/N Rats. Experimental Lung Research 23:1, pages 65-84.
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Terry Gordon, Christine Nadziejko, Matthew Plant, Ian W. Rodger & Douglas J. Pon. (1996) One-Month Exposure to Inhaled Endotoxin Produces a Dose-Dependent Increase in Stored Mucosubstances in Rat Intrapulmonary Airways. Experimental Lung Research 22:5, pages 509-523.
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Articles from other publishers (29)

Pilar Patiño, Carolina Gallego, Nhora Martínez, Alba Rey & Carlos Iregui. (2022) Intranasal instillation of Pasteurella multocida lipopolysaccharide in rabbits causes interstitial lung damage. Research in Veterinary Science 152, pages 115-126.
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Magda Patricia Carrillo, Nhora María Martinez, María del Pilar Patiño & Carlos Arturo Iregui. (2015) Inhibition of Pasteurella multocida Adhesion to Rabbit Respiratory Epithelium Using Lectins . Veterinary Medicine International 2015, pages 1-10.
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Olivier Rolin, Will Smallridge, Michael Henry, Laura Goodfield, David Place & Eric T. Harvill. (2014) Toll-Like Receptor 4 Limits Transmission of Bordetella bronchiseptica. PLoS ONE 9:1, pages e85229.
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Stephan A. CareyCarol A. BallingerCharles G. PlopperRuth J. McDonaldAlfred A. Bartolucci, Edward M. PostlethwaitJack R. Harkema. (2011) Persistent rhinitis and epithelial remodeling induced by cyclic ozone exposure in the nasal airways of infant monkeys. American Journal of Physiology-Lung Cellular and Molecular Physiology 300:2, pages L242-L254.
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Juan Carlos Abanses, Shinobu Arima & Bruce K. Rubin. (2009) Vicks VapoRub Induces Mucin Secretion, Decreases Ciliary Beat Frequency, and Increases Tracheal Mucus Transport in the Ferret Trachea. Chest 135:1, pages 143-148.
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Yohannes A. Mebratu, Burton F. Dickey, Chris Evans & Yohannes Tesfaigzi. (2008) The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNγ-induced cell death. The Journal of Cell Biology 183:3, pages 429-439.
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James J. Pestka, Iwona Yike, Dorr G. Dearborn, Marsha D. W. Ward & Jack R. Harkema. (2008) Stachybotrys chartarum, Trichothecene Mycotoxins, and Damp Building–Related Illness: New Insights into a Public Health Enigma. Toxicological Sciences 104:1, pages 4-26.
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Jialing Xiang, Jules Rir-Sim-Ah & Yohannes Tesfaigzi. (2008) IL-9 and IL-13 Induce Mucous Cell Metaplasia That Is Reduced by IFN-γ in a Bax-Mediated Pathway. American Journal of Respiratory Cell and Molecular Biology 38:3, pages 310-317.
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Zahidul Islam, Chidozie J. Amuzie, Jack R. Harkema & James J. Pestka. (2007) Neurotoxicity and Inflammation in the Nasal Airways of Mice Exposed to the Macrocyclic Trichothecene Mycotoxin Roridin A: Kinetics and Potentiation by Bacterial Lipopolysaccharide Coexposure. Toxicological Sciences 98:2, pages 526-541.
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Joseph Pierce, Jules Rir-Sima-Ah, Isaac Estrada, Julie Wilder, Andreas Strasser & Yohannes Tesfaigzi. (2006) Loss of pro-apoptotic Bim promotes accumulation of pulmonary T lymphocytes and enhances allergen-induced goblet cell metaplasia. American Journal of Physiology-Lung Cellular and Molecular Physiology 291:5, pages L862-L870.
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Jack R. Harkema & James G. Wagner. (2005) Epithelial and inflammatory responses in the airways of laboratory rats coexposed to ozone and biogenic substances: Enhancement of toxicant-induced airway injury. Experimental and Toxicologic Pathology 57, pages 129-141.
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J. Foster Harris, Mark J. Fischer, Jon R. Hotchkiss, Brett P. Monia, Scott H. Randell, Jack R. Harkema & Yohannes Tesfaigzi. (2005) Bcl-2 Sustains Increased Mucous and Epithelial Cell Numbers in Metaplastic Airway Epithelium. American Journal of Respiratory and Critical Care Medicine 171:7, pages 764-772.
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Yohannes Tesfaigzi, J. Foster Harris, Jon A. Hotchkiss & Jack R. Harkema. (2004) DNA synthesis and Bcl-2 expression during development of mucous cell metaplasia in airway epithelium of rats exposed to LPS. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:2, pages L268-L274.
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Sumihisa Sueyoshi, Yuki Miyata, Yoshihiro Masumoto, Yuji Ishibashi, Shigeki Matsuzawa, Naoki Harano, Kiyoyuki Tsuru & Shigeru Imai. (2004) Reduced Airway Inflammation and Remodeling in Parallel with Mucin 5AC Protein Expression Decreased by S-Carboxymethylcysteine, a Mucoregulant, in the Airways of Rats Exposed to Sulfur Dioxide. International Archives of Allergy and Immunology 134:4, pages 273-280.
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Jennifer E. Foster, Katherine Gott, Mark R. Schuyler, Wieslaw Kozak & Yohannes Tesfaigzi. (2003) LPS-induced neutrophilic inflammation and Bcl-2 expression in metaplastic mucous cells. American Journal of Physiology-Lung Cellular and Molecular Physiology 285:2, pages L405-L414.
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Marja J. Nell & Jan J. Grote. (2016) Effects of Bacterial Toxins on Air-Exposed Cultured Human Respiratory Sinus Epithelium. Annals of Otology, Rhinology & Laryngology 112:5, pages 461-468.
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J G WagnerJ A HotchkissJ R Harkema. (2001) Effects of ozone and endotoxin coexposure on rat airway epithelium: potentiation of toxicant-induced alterations.. Environmental Health Perspectives 109:suppl 4, pages 591-598.
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Takeshi Shimizu, Yukimitsu Takahashi, Yuichi Majima, Kazuhiko Takeuchi & Yasuo Sakakura. (2016) Role of Neutrophil Elastase in Endotoxin-Induced Mucus Hypersecretion in Rat Nasal Epithelium. Annals of Otology, Rhinology & Laryngology 109:11, pages 1049-1054.
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Hye Y. Cho, Jon A. Hotchkiss, Catherine B. Bennett & Jack R. Harkema. (1999) Effects of Pre-existing Rhinitis on Ozone-Induced Mucous Cell Metaplasia in Rat Nasal Epithelium. Toxicology and Applied Pharmacology 158:2, pages 92-102.
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Jack R. Harkema, Jon A. Hotchkiss, Edward B. Barr, Catherine B. Bennett, Marianne Gallup, Jong Kwon Lee & Carol Basbaum. (1999) Long-Lasting Effects of Chronic Ozone Exposure on Rat Nasal Epithelium. American Journal of Respiratory Cell and Molecular Biology 20:3, pages 517-529.
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Michelle V. Fanucchi, Jon A. Hotchkiss & Jack R. Harkema. (1998) Endotoxin Potentiates Ozone-Induced Mucous Cell Metaplasia in Rat Nasal Epithelium. Toxicology and Applied Pharmacology 152:1, pages 1-9.
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Austin S. Rose, Jiri Prazma, Scott H. Randell, Henry C. Baggett, Andrew P. Lane & Harold C. Pillsbury. (2016) Nitric Oxide Mediates Mucin Secretion in Endotoxin‐Induced Otitis Media with Effusion. Otolaryngology–Head and Neck Surgery 116:3, pages 308-316.
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Dechun Li & Peter K. Jeffery. 1997. Airway Mucus: Basic Mechanisms and Clinical Perspectives. Airway Mucus: Basic Mechanisms and Clinical Perspectives 227 273 .
M.B. Snipes, A.L. Barnett, J.R. Harkema, J.A. Hotchkiss, A.H. Rebar & L.J. Reddick. (2009) Specific Biological Effects of an Anti‐Rat PMN Antiserum Intraperitoneally Injected into F344/N Rats. Veterinary Clinical Pathology 24:1, pages 11-17.
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H. Ohmori, A.F. Dohrman, M. Gallup, T. Tsuda, H. Kai, J.R. GumJrJr, Y.S. Kim & C.B. Basbaum. (1994) Molecular cloning of the amino-terminal region of a rat MUC 2 mucin gene homologue. Evidence for expression in both intestine and airway.. Journal of Biological Chemistry 269:27, pages 17833-17840.
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J M SametP W Cheng. (1994) The role of airway mucus in pulmonary toxicology.. Environmental Health Perspectives 102:suppl 2, pages 89-103.
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J. R. Harkema & J. A. Hotchkiss. (2005) In vivo effects of endotoxin on DNA synthesis in rat nasal epithelium. Microscopy Research and Technique 26:5, pages 457-465.
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Jack R. Harkema & Jon A. Hotchkiss. (1993) Ozone- and endotoxin-induced mucous cell metaplasias in rat airway epithelium: Novel animal models to study toxicant-induced epithelial transformation in airways. Toxicology Letters 68:1-2, pages 251-263.
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Rogene F. Henderson, Jack R. Harkema, Jon A. Hotchkiss & Déa S. Boehme. (1991) Effect of blood leucocyte depletion on the inflammatory response of the lung to quartz. Toxicology and Applied Pharmacology 109:1, pages 127-136.
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