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Experimental Lung Research Volume 18, 1992 - Issue 5
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Original Article

Passage of Aerosolized BSA and the Nona-peptide dDAVP via the Respiratory Tract in Young and Adult Rats

H. G. Folkesson Department of Animal Physiology, Department of Pharmacology, Astra Draco, and Department of Clinical Pharmacology, University of Lund, Lund, Sweden
,
B. R. Weström Department of Animal Physiology, Department of Pharmacology, Astra Draco, and Department of Clinical Pharmacology, University of Lund, Lund, Sweden
,
M. Dahlbäck Department of Animal Physiology, Department of Pharmacology, Astra Draco, and Department of Clinical Pharmacology, University of Lund, Lund, Sweden
,
S. Lundin Department of Animal Physiology, Department of Pharmacology, Astra Draco, and Department of Clinical Pharmacology, University of Lund, Lund, Sweden
&
B. W. Karlsson Department of Animal Physiology, Department of Pharmacology, Astra Draco, and Department of Clinical Pharmacology, University of Lund, Lund, Sweden
Pages 595-614 | Published online: 02 Jul 2009

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Yasuhisa Matsukawa, Hiroshi Yamahara, Fumiyoshi Yamashita, Vincent H.L. Lee, Edward D. Crandall & Kwang-Jin Kim. (1999) Rates of Protein Transport Across Rat Alveolar Epithelial Cell Monolayers. Journal of Drug Targeting 7:5, pages 335-342.
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Doris A. Wall. (1995) Pulmonary Absorption of Peptides and Proteins. Drug Delivery 2:1, pages 1-20.
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Articles from other publishers (24)

Thomas Schupp & Patrick M Plehiers. (2022) Absorption, distribution, metabolism, and excretion of methylene diphenyl diisocyanate and toluene diisocyanate: Many similarities and few differences. Toxicology and Industrial Health 38:9, pages 500-528.
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Andrew M. Shen & Tamara Minko. (2020) Pharmacokinetics of inhaled nanotherapeutics for pulmonary delivery. Journal of Controlled Release 326, pages 222-244.
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Janet C. Gould, Irvith Carvajal, Todd Davidson, Jessica Graham, Jedd Hillegass, Susan Julien, Alex Kozhich, Bonnie Wang, Hui Wei, Aaron P. Yamniuk, Neil Mathias, Helen G. Haggerty & Michael Graziano. (2018) Bioavailability of protein therapeutics in rats following inhalation exposure: Relevance to occupational exposure limit calculations. Regulatory Toxicology and Pharmacology 100, pages 35-44.
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Shadabul Haque, Victoria M. McLeod, Seth Jones, Sandy Fung, Michael Whittaker, Michelle McIntosh, Colin Pouton, David J. Owen, Christopher J.H. Porter & Lisa M. Kaminskas. (2017) Effect of increased surface hydrophobicity via drug conjugation on the clearance of inhaled PEGylated polylysine dendrimers. European Journal of Pharmaceutics and Biopharmaceutics 119, pages 408-418.
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Janet Gould, Courtney M. Callis, David G. Dolan, Brad Stanard & Patricia A. Weideman. (2016) Special endpoint and product specific considerations in pharmaceutical acceptable daily exposure derivation. Regulatory Toxicology and Pharmacology 79, pages S79-S93.
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Nitesh K. Kunda, Iman M. Alfagih, Imran Y. Saleem & Gillian A. Hutcheon. 2015. Pulmonary Drug Delivery. Pulmonary Drug Delivery 301 320 .
Richard J. Prankerd, Tri-Hung Nguyen, Jibriil P. Ibrahim, Robert J. Bischof, Gemma C. Nassta, Livesey D. Olerile, Adrian S. Russell, Felix Meiser, Helena C. Parkington, Harold A. Coleman, David A. V. Morton & Michelle P. McIntosh. (2013) Pulmonary Delivery of an Ultra-Fine Oxytocin Dry Powder Formulation: Potential for Treatment of Postpartum Haemorrhage in Developing Countries. PLoS ONE 8:12, pages e82965.
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Gemma M. Ryan, Lisa M. Kaminskas, Brian D. Kelly, David J. Owen, Michelle P. McIntosh & Christopher J. H. Porter. (2013) Pulmonary Administration of PEGylated Polylysine Dendrimers: Absorption from the Lung versus Retention within the Lung Is Highly Size-Dependent. Molecular Pharmaceutics 10:8, pages 2986-2995.
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Yasmin Buchäckert, Sebastian Rummel, Christine U. Vohwinkel, Nieves M. Gabrielli, Benno A. Grzesik, Konstantin Mayer, Susanne Herold, Rory E. Morty, Werner Seeger & István Vadász. (2012) Megalin mediates transepithelial albumin clearance from the alveolar space of intact rabbit lungs. The Journal of Physiology 590:20, pages 5167-5181.
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Fernanda Andrade, Mafalda Videira, Domingos Ferreira & Bruno Sarmento. (2011) Nanocarriers for pulmonary administration of peptides and therapeutic proteins. Nanomedicine 6:1, pages 123-141.
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Hemal Tandel, Kiruba Florence & Ambikanandan Misra. 2011. Challenges in Delivery of Therapeutic Genomics and Proteomics. Challenges in Delivery of Therapeutic Genomics and Proteomics 429 479 .
Ewa SelgFernando AcevedoRolf NybomBo BlomgrenÅke RyrfeldtPer Gerde. (2010) Delivering Horseradish Peroxidase as a Respirable Powder to the Isolated, Perfused, and Ventilated Lung of the Rat: The Pulmonary Disposition of an Inhaled Model Biopharmaceutical. Journal of Aerosol Medicine and Pulmonary Drug Delivery 23:5, pages 273-284.
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Fergus Manford, Yanira Riffo-Vasquez, Domenico Spina, Clive P Page, Andrew J Hutt, Vanessa Moore, Fredrik Johansson & Ben Forbes. (2008) Lack of difference in pulmonary absorption of digoxin, a P-glycoprotein substrate, in mdr1a -deficient and mdr1a -competent mice . Journal of Pharmacy and Pharmacology 60:10, pages 1305-1310.
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Randolph H. Hastings, Hans G. Folkesson & Michael A. Matthay. (2004) Mechanisms of alveolar protein clearance in the intact lung. American Journal of Physiology-Lung Cellular and Molecular Physiology 286:4, pages L679-L689.
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Ann Tronde, George Baran, Stefan Eirefelt, Hans Lennernäs & Ursula Hultkvist Bengtsson. (2002) Miniaturized Nebulization Catheters: A New Approach for Delivery of Defined Aerosol Doses to the Rat Lung. Journal of Aerosol Medicine 15:3, pages 283-296.
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Eva Krondahl, Ann Tronde, Stefan Eirefelt, Heidi Forsmo-Bruce, Gunilla Ekstr?m, Ursula Hultkvist Bengtsson & Hans Lennern?s. (2002) Regional differences in bioavailability of an opioid tetrapeptide in vivo in rats after administration to the respiratory tract. Peptides 23:3, pages 479-488.
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CEDRIC HERMANS & ALFRED BERNARD. (1999) Lung Epithelium–specific Proteins. American Journal of Respiratory and Critical Care Medicine 159:2, pages 646-678.
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Bo L. Koch, ÅSa A. Edvinsson & Lars-Owe D. Koskinen. (1999) Inhalation of substance P and thiorphan: acute toxicity and effects on respiration in conscious guinea pigs. Journal of Applied Toxicology 19:1, pages 19-23.
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HANS G. FOLKESSON, BJÖRN R. WESTRÖM & BÖRJE W. KARLSSON. (1998) Effects of Systemic and Local Immunization on Alveolar Epithelial Permeability to Protein in the Rat. American Journal of Respiratory and Critical Care Medicine 157:1, pages 324-327.
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Yasuhisa Matsukawa, Vincent H.L. Lee, Edward D. Crandall & Kwang-Jin Kim. (1997) Size-Dependent Dextran Transport across Rat Alveolar Epithelial Cell Monolayers. Journal of Pharmaceutical Sciences 86:3, pages 305-309.
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Kwang-Jin Kim & Edward D. Crandall. 1996. Models for Assessing Drug Absorption and Metabolism. Models for Assessing Drug Absorption and Metabolism 325 346 .
Pratik Saha, Kwang-Jin Kim, Hiroshi Yamahara, Edward D. Crandall & Vincent H.L. Lee. (1994) Influence of lipophilicity on β-blocker permeation across rat alveolar epithelial cell monolayers. Journal of Controlled Release 32:2, pages 191-200.
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A. Adjei & P. Gupta. (1994) Pulmonary delivery of therapeutic peptides and proteins. Journal of Controlled Release 29:3, pages 361-373.
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H. G. FOLKESSON, B. R. WESTRÖM, S. G. PIERZYNOWSKI, J. SVENDSEN & B. W. KARLSSON. (2008) Lung to blood passage of albumin and a nona‐peptide after intratracheal instillation in the young developing pig. Acta Physiologica Scandinavica 147:2, pages 173-178.
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