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Ultrastructural Pathology Volume 4, 1983 - Issue 2-3
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Original Article

Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma): Ultrastructural and Immunohistochemical Demonstration of Neurofilaments

Markku Miettinen Department of Pathology, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki 29, Finland
,
Veli-Pekka Lehto Department of Pathology, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki 29, Finland
,
Ismo Virtanen Department of Pathology, University of Helsinki, Haartmaninkatu 3, SF-00290, Helsinki 29, Finland
,
Sirpa Asko-Seljavaara Division of Plastic Surgery, Helsinki University Central Hospital
,
Jaakko Pitkänen Division of Plastic Surgery, Helsinki University Central Hospital
&
Doris Dahl Harvard Medical School and Spinal Cord Injury Service, West Roxbury Veterans Administration Medical Center, Boston, Massachusetts, 02115
Pages 219-225 | Published online: 10 Jul 2009

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Read on this site (10)

Virve Koljonen. (2010) Merkel cell carcinoma: what we know now. Expert Review of Dermatology 5:3, pages 345-355.
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Michael J. Esposito, Stanley H. Shapiro & Hilda Laufer. (1994) Merkel Cell Tumor of the Penis. Journal of Histotechnology 17:4, pages 361-363.
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Adam Borit, Thomas E. Brooks, Nelson G. Ordóñez, Byron Arthur Kakulas & Lawrence F. Eng. (1986) Central Neural Antigens: Detection and Diagnostic Application. CRC Critical Reviews in Clinical Laboratory Sciences 23:3, pages 219-243.
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Roland Moll, Mary Osborn, Wolfgang Hartschuh, Ingrid Moll, Gustav Mahrle & Klaus Weber. (1986) Variability of Expression and Arrangement of Cytokeratin and Neurofilaments in Cutaneous Neuroendocrine Carcinomas (Merkel Cell Tumors): Immunocytochemical and Biochemical Analysis of Twelve Cases. Ultrastructural Pathology 10:6, pages 473-495.
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Anthony S-Y Leong, G. E. Phillips, A. S. Pieterse & J. Milios. (1986) Criteria for the Diagnosis of Primary Endocrine Carcinoma of the Skin (Merkel cell Carcinoma). A Histological, Immunohistochemical and Ultrastructural Study of 13 Cases. Pathology 18:4, pages 393-399.
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Anthony S-Y Leong & B. R. Dixon. (1986) Bidirectional Differentiation in a Large Cell Pleomorphic Primary Endocrine Carcinoma of the Skin (A Variant of Malignant Merkel Cell Tumour). Pathology 18:2, pages 256-261.
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Victor E. Gould, Inchul Lee & Samuel P. Hammar. (1985) Neuroendocrine Skin Carcinoma Coexpressing Cytokeratin and Neurofilament Proteins. Ultrastructural Pathology 9:1-2, pages 83-90.
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Michael A. McNutt, John W. Bolen, Allen M. Gown, Samuel P. Hammar & Arthur M. Vogel. (1985) Coexpression of Intermediate Filaments in Human Epithelial Neoplasms. Ultrastructural Pathology 9:1-2, pages 31-43.
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Markku Miettinen, Veli-Pekka Lehto & Ismo Virtanen. (1984) Antibodies to Intermediate Filament Proteins in the Diagnosis and Classification of Human Tumors. Ultrastructural Pathology 7:2-3, pages 83-107.
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William R. Green, R. Ilona Linnoila & Timothy J. Triche. (1984) Neuroendocrine Carcinoma of Skin with Simultaneous Cytokeratin Expression. Ultrastructural Pathology 6:2-3, pages 141-152.
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Articles from other publishers (42)

Benjamin Johansson, Helka Sahi, Virve Koljonen & Tom Böhling. (2019) The expression of terminal deoxynucleotidyl transferase and paired box gene 5 in Merkel cell carcinomas and its relation to the presence of Merkel cell polyomavirus DNA. Journal of Cutaneous Pathology 46:1, pages 26-32.
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Stefan KraftScott R. Granter. (2014) Molecular Pathology of Skin Neoplasms of the Head and Neck. Archives of Pathology & Laboratory Medicine 138:6, pages 759-787.
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Timothy H. McCalmont. (2010) Paranuclear dots of neurofilament reliably identify Merkel cell carcinoma. Journal of Cutaneous Pathology 37:8, pages 822-823.
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David M. Mills, Dale R. Meyer, Joseph W. Sassani, Ahmed A. Hidayat & Frederick A. Jakobiec. 2008. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology. Albert &amp Jakobiec's Principles &amp Practice of Ophthalmology 3379 3394 .
Virve Koljonen. (2006) Merkel cell carcinoma. World Journal of Surgical Oncology 4:1.
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Hadi Yaziji & Allen M. Gown. (2000) Merkel cell carcinoma. Cancer 89:8, pages 1866-1867.
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Patricia TH Tai, Edward Yu, Jon Tonita & James Gilchrist. (2016) Merkel Cell Carcinoma of the Skin. Journal of Cutaneous Medicine and Surgery 4:4, pages 186-195.
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Tilman Schulz & Wolfgang Hartschuh. (1997) Merkel cells are absent in basal cell carcinomas but frequently found in trichoblastomas. An immunohistochemical study. Journal of Cutaneous Pathology 24:1, pages 14-24.
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MICHAEL L. HAAG, FRANK L. GLASS & NEIL A. FENSKE. (1995) Merkel Cell Carcinoma Diagnosis and Treatment. Dermatologic Surgery 21:8, pages 669-683.
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Ingrid Moll, Caedilie Kuhn & Roland Moll. (1995) Cytokeratin 20 Is a General Marker of Cutaneous Merkel Cells While Certain Neuronal Proteins Are Absent. Journal of Investigative Dermatology 104:6, pages 910-915.
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Hisashi Uhara, Yu‐Lai Wang, Sachiyo Matsumoto, Shigeo Kawachi & Toshiaki Saida. (2006) Expression of α subunit of guanine nucleotide‐binding protein G o in Merkel cell carcinoma . Journal of Cutaneous Pathology 22:2, pages 146-148.
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Maria P. Foschini & Vincenzo Eusebi. (1995) The spectrum of endocrine tumours of skin. Current Diagnostic Pathology 2:1, pages 2-9.
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Tero Kivelä & Ahti Tarkkanen. (1990) The Merkel cell and associated neoplasms in the eyelids and periocular region. Survey of Ophthalmology 35:3, pages 171-187.
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André J. Balaton, Fréderique Capron, Erno E. Baviéra, Pierre Meyrignac, Philippe Vauri & Phat N. Vuong. (1989) Neuroendocrine Carcinoma (Merkel Cell Tumor?) Presenting as a Subcutaneous Tumor. Pathology - Research and Practice 184:2, pages 211-216.
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I. Damjanov, B. Tuma & M. Dominis. (1989) Electron Microscopy of Large Cell Undifferentiated and Giant Cell Tumors. Pathology - Research and Practice 184:2, pages 137-160.
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S. Senatore, L. Zizzi, D. D'Astore, G. Saccani Jotti & M. Gabrielli. (2018) Neuroendocrine Carcinoma of the Skin (Merkel Cell Carcinoma): Immunocytochemical Study of a Case. The International Journal of Biological Markers 3:2, pages 129-134.
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Feroze N. Ghadially. 1988. Ultrastructural Pathology of the Cell and Matrix. Ultrastructural Pathology of the Cell and Matrix 839 936 .
A. Rocamora, N. Badía, R. Vives, R. Carrillo, J. Ulloa & A. Ledo. (1987) Epidermotropic primary neuroendocrine (Merkel cell) carcinoma of the skin with Pautrier-like microabscesses. Journal of the American Academy of Dermatology 16:6, pages 1163-1168.
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Yoshito Sadahira, Shu Nakamoto, Masaharu Mori, Chao Liang Hsueh & Michiyasu Awai. (2008) MERKEL CELL TUMOR COEXPRESSING CYTOKERATIN AND NEUROFILAMENT PROTEINS. Pathology International 37:2, pages 331-337.
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Ingrid Moll, Roland Moll & Werner W Franke. (1986) Formation of Epidermal and Dermal Merkel Cells During Human Fetal Skin Development. Journal of Investigative Dermatology 87:6, pages 779-787.
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P.A. HALL, A.J. D'ARDENNE, M.G. BUTLER, P.M. STEARN, S.G. SUBBUSWAMY, A.J. BLACKSHAW & D.A. LEVISON. (2007) Cytokeratin and laminin immunostaining in the diagnosis of cutaneous neuro‐endocrine (Merkel cell) tumours. Histopathology 10:11, pages 1179-1190.
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Hector Battifora & Elvio G. Silva. (1986) The use of antikeratin antibodies in the immunohistochemical distinction between neuroendocrine (merkel cell) carcinoma of the skin, lymphoma, and oat cell carcinoma. Cancer 58:5, pages 1040-1046.
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L.K. Trejdosiewicz, Jennifer Southgate, J.T. Kemshead & Gisèle M. Hodges. (1986) Phenotypic analysis of cultured melanoma cells. Experimental Cell Research 164:2, pages 388-398.
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Francis P. Kuhajda, Jean L. Olson & Risa B. Mann. (1986) Merkel cell (small cell) carcinoma of the skin: Immunohistochemical and ultrastructural demonstration of distinctive perinuclear cytokeratin aggregates and a possible association with B cell neoplasms. The Histochemical Journal 18:5, pages 239-244.
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M. Drijkoningen, C. De Wolf-Peeters, E. Van Limbergen & V. Desmet. (1986) Merkel cell tumor of the skin: An immunohistochemical study. Human Pathology 17:3, pages 301-307.
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Chikao Torikata, Makio Mukai, Hirobumi Kawakita & Keizo Kageyama. (1986) NEUROFILAMENTS OF KULTSCHITSKY CELLS IN HUMAN LUNG. Pathology International 36:1, pages 93-104.
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Yves Merot, Randall J. Margolis, Doris Dahl, Jean-H Saurat & Martin C MihmJrJr. (1986) Coexpression of Neurofilament and Keratin Proteins in Cutaneous Neuroendocrince Carcinoma Cells. Journal of Investigative Dermatology 86:1, pages 74-77.
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Veli-Pekka Lehto, Jonas Bergh & Ismo Virtanen. 1986. Lung Cancer: Basic and Clinical Aspects. Lung Cancer: Basic and Clinical Aspects 1 30 .
I. VIRTANEN, M. MIETTINEN, V. -P. LEHTO, A. -L. KARINIEMI & R. PAASIVUO. (1985) Diagnostic Application of Monoclonal Antibodies to Intermediate Filaments. Annals of the New York Academy of Sciences 455:1 Intermediate, pages 635-648.
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E. BIRGITTE LANE, JIRÍ BÁRTEK, PATRICIA E. PURKIS & IRENE M. LEIGH. (1985) Keratin Antigens in Differentiating Skin. Annals of the New York Academy of Sciences 455:1 Intermediate, pages 241-258.
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Emily L. Leff, John S. J. Brooks & John Q. Trojanowski. (1985) Expression of neurofilament and neuron-specific enolase in small cell tumors of skin using immunohistochemistry. Cancer 56:3, pages 625-631.
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Kenji Matsuo, Akira Sakamoto, Kioko Kawai, HIDEO Tschiyama & Akimi Miyata. (2008) SMALL CELL CARCINOMA OF THE SKIN “NON‐MERKEL CELL TYPE”. Pathology International 35:4, pages 1029-1036.
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H. H�fler, H. Kerl, E. Lackinger, G. Helleis & H. Denk. (1985) The intermediate filament cytoskeleton of cutaneous neuroendocrine carcinoma (Merkel cell tumour). Virchows Archiv A Pathological Anatomy and Histopathology 406:3, pages 339-350.
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Roland Moll, Ingrid Moll & Werner W. Franke. (1984) Identification of Merkel cells in human skin by specific cytokeratin antibodies:. Differentiation 28:2, pages 136-154.
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Jean-H Saurat, Yves Merot, Liliane Didierjean & Doris Dahl. (1984) Normal Rabbit Merkel Cells Do Not Express Neurofilament Proteins. Journal of Investigative Dermatology 82:6, pages 641-642.
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D. Dahl, M. Grossi & A. Bignami. (1984) Masking of epitopes in tissue sections. Histochemistry 81:6, pages 525-531.
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