173
Views
41
CrossRef citations to date
0
Altmetric
Original Article

Solvent extraction employing a static micromixer: A simple, robust and versatile technology for the microencapsulation of proteins

, , &
Pages 67-85 | Received 03 Jan 2002, Accepted 26 Mar 2002, Published online: 02 Jul 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Articles from other publishers (40)

Ye Zhang, Yong Gao, Peng Wang, Duo Na, Zhenming Yang & Jinsong Zhang. (2022) Solvent extraction of Ce(III) and Pr(III) with P507 using SiC foam as a static mixer. Journal of Rare Earths 40:4, pages 676-686.
Crossref
Jiajia Xu, Xueye Chen, Yanlin Liu & Zhen Yao. (2018) Numerical study on micromixers with smart-rhombic structure. International Journal of Modern Physics B 32:27, pages 1850301.
Crossref
Mahtab Izadi, Masoud Rahimi & Reza Beigzadeh. (2018) An investigation of mixing performance in helically coiled microchannels by the Villermaux/Dushman reaction. Chemical Engineering Research and Design 134, pages 507-517.
Crossref
Mubashshir Ansari, Kwang-Yong Kim & Sun Kim. (2018) Numerical and Experimental Study on Mixing Performances of Simple and Vortex Micro T-Mixers. Micromachines 9:5, pages 204.
Crossref
Yanlin Zhang, Robert W. Cattrall & Spas D. Kolev. (2017) Fast and Environmentally Friendly Microfluidic Technique for the Fabrication of Polymer Microspheres. Langmuir 33:51, pages 14691-14698.
Crossref
Shilpa Sivashankar, Sumeyra Agambayev, Yousof Mashraei, Er Qiang Li, Sigurdur T. Thoroddsen & Khaled Nabil Salama. (2016) A “twisted” microfluidic mixer suitable for a wide range of flow rate applications. Biomicrofluidics 10:3.
Crossref
Peng Liu, Yi Zhong & Yan Luo. (2014) Preparation of monodisperse biodegradable magnetic microspheres using a T-shaped microchannel reactor. Materials Letters 117, pages 37-40.
Crossref
F.R. Formiga, E. Garbayo, P. Díaz-Herráez, G. Abizanda, T. Simón-Yarza, E. Tamayo, F. Prósper & M.J. Blanco-Prieto. (2013) Biodegradation and heart retention of polymeric microparticles in a rat model of myocardial ischemia. European Journal of Pharmaceutics and Biopharmaceutics 85:3, pages 665-672.
Crossref
Annina M. Hafner, Blaise Corthésy & Hans P. Merkle. (2013) Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant. Advanced Drug Delivery Reviews 65:10, pages 1386-1399.
Crossref
Xiangsong Feng, Yukun Ren & Hongyuan Jiang. (2013) An effective splitting-and-recombination micromixer with self-rotated contact surface for wide Reynolds number range applications. Biomicrofluidics 7:5.
Crossref
Qinhua Zuo, Jianbo Lu, An Hong, Dagen Zhong, Shasha Xie, Quan Liu, Yuexin Huang, Yunfeng Shi, Liumin He & Wei Xue. (2012) Preparation and characterization of PEM-coated alginate microgels for controlled release of protein. Biomedical Materials 7:3, pages 035012.
Crossref
Ronald X. Xu. (2011) Multifunctional microbubbles and nanobubbles for photoacoustic imaging. Contrast Media & Molecular Imaging 6:5, pages 401-411.
Crossref
Kazuo Matsuyama, Koji Mine, Hideaki Kubo, Nobuaki Aoki & Kazuhiro Mae. (2010) Optimization methodology of operation of orifice-shaped micromixer based on micro-jet concept. Chemical Engineering Science 65:22, pages 5912-5920.
Crossref
Shayne Cox GadShunmugaperumal Tamilvanan. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia.
Gi Seok Jeong, Seok Chung, Chang-Beom Kim & Sang-Hoon Lee. (2010) Applications of micromixing technology. The Analyst 135:3, pages 460.
Crossref
Mingbo Wang, Qingling Feng, Xufeng Niu, Rongwei Tan & Zhending She. (2010) A spheres-in-sphere structure for improving protein-loading poly (lactide-co-glycolide) microspheres. Polymer Degradation and Stability 95:1, pages 6-13.
Crossref
Manuel J. Santander-Ortega, Noemi Csaba, Lisette González, Delfina Bastos-González, Juan L. Ortega-Vinuesa & Maria J. Alonso. (2009) Protein-loaded PLGA–PEO blend nanoparticles: encapsulation, release and degradation characteristics. Colloid and Polymer Science 288:2, pages 141-150.
Crossref
Dhananjay Dendukuri & Patrick S. Doyle. (2009) The Synthesis and Assembly of Polymeric Microparticles Using Microfluidics. Advanced Materials 21:41, pages 4071-4086.
Crossref
A. Ellis & J.C. Jacquier. (2009) Manufacture of food grade κ-carrageenan microspheres. Journal of Food Engineering 94:3-4, pages 316-320.
Crossref
Julia M. Martínez Gómez, Noémi Csaba, Stefan Fischer, Anke Sichelstiel, Thomas M. Kündig, Bruno Gander & Pål Johansen. (2008) Surface coating of PLGA microparticles with protamine enhances their immunological performance through facilitated phagocytosis. Journal of Controlled Release 130:2, pages 161-167.
Crossref
Jayoung KimDasom HongYounglim ChungHongkee Sah. (2007) Ammonolysis-Induced Solvent Removal: A Facile Approach for Solidifying Emulsion Droplets into PLGA Microspheres. Biomacromolecules 8:12, pages 3900-3907.
Crossref
Julia M. Martínez Gómez, Stefan Fischer, Noèmi Csaba, Thomas M. Kündig, Hans P. Merkle, Bruno Gander & Pål Johansen. (2007) A Protective Allergy Vaccine Based on CpG- and Protamine-Containing PLGA Microparticles. Pharmaceutical Research 24:10, pages 1927-1935.
Crossref
Stefan Fischer, Edith Uetz-von Allmen, Ying Waeckerle-Men, Marcus Groettrup, Hans P. Merkle & Bruno Gander. (2007) The preservation of phenotype and functionality of dendritic cells upon phagocytosis of polyelectrolyte-coated PLGA microparticles. Biomaterials 28:6, pages 994-1004.
Crossref
V. Hessel, P. Löb, U. Krtschil & H. Löwe. 2007. New Avenues to Efficient Chemical Synthesis. New Avenues to Efficient Chemical Synthesis 205 240 .
Chia-Che Wu, Cheng-Chun Lee, G. Z. Cao & I. Y. Shen. (2006) Feasibility Study of Smart PZT Thin-Film Microresonators. Feasibility Study of Smart PZT Thin-Film Microresonators.
Rafael Vargas-Bernal. (2006) Selection of Micromixers for Biochemical Detection of Pesticides. Selection of Micromixers for Biochemical Detection of Pesticides.
Christian Wischke, Hans-Hubert Borchert, Julian Zimmermann, Ingo Siebenbrodt & Dirk R. Lorenzen. (2006) Stable cationic microparticles for enhanced model antigen delivery to dendritic cells. Journal of Controlled Release 114:3, pages 359-368.
Crossref
Stefan Fischer, Christina Foerg, Sabine Ellenberger, Hans P. Merkle & Bruno Gander. (2006) One-step preparation of polyelectrolyte-coated PLGA microparticles and their functionalization with model ligands. Journal of Controlled Release 111:1-2, pages 135-144.
Crossref
Farahidah Mohamed & Christopher F. van der Walle. (2006) PLGA microcapsules with novel dimpled surfaces for pulmonary delivery of DNA. International Journal of Pharmaceutics 311:1-2, pages 97-107.
Crossref
Sergio Freitas, Gerhard Hielscher, Hans P. Merkle & Bruno Gander. (2006) Continuous contact- and contamination-free ultrasonic emulsification—a useful tool for pharmaceutical development and production. Ultrasonics Sonochemistry 13:1, pages 76-85.
Crossref
V. Hessel, H. Löwe, C. Serra & G. Hadziioannou. (2005) Polymerisationen in mikrostrukturierten Reaktoren: Ein Überblick. Chemie Ingenieur Technik 77:11, pages 1693-1714.
Crossref
S. Hardt, F. Jiang & F. Schönfeld. (2005) A computational analysis of the hydrodynamic instability of a liquid jet focused into a converging microchannel. International Journal of Multiphase Flow 31:6, pages 739-756.
Crossref
Volker Hessel, Holger Löwe & Friedhelm Schönfeld. (2005) Micromixers—a review on passive and active mixing principles. Chemical Engineering Science 60:8-9, pages 2479-2501.
Crossref
H. Pennemann, S. Hardt, V. Hessel, P. Löb & F. Weise. (2005) Micromixer Based Liquid/Liquid Dispersion. Chemical Engineering & Technology 28:4, pages 501-508.
Crossref
Sergio Freitas, Hans P. Merkle & Bruno Gander. (2005) Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. Journal of Controlled Release 102:2, pages 313-332.
Crossref
Kathrin Schalper, Stephan Harnisch, Rainer H. M�ller & Gesine E. Hildebrand. (2005) Preparation of Microparticles by Micromixers: Characterization of Oil/Water Process and Prediction of Particle Size. Pharmaceutical Research 22:2, pages 276-284.
Crossref
Patrick Löb, Helmut Pennemann & Volker Hessel. (2004) g/l-Dispersion in interdigital micromixers with different mixing chamber geometries. Chemical Engineering Journal 101:1-3, pages 75-85.
Crossref
Marı́a J. Blanco-Prı́eto, Miguel A. Campanero, Kamel Besseghir, F. Heimgatner & Bruno Gander. (2004) Importance of single or blended polymer types for controlled in vitro release and plasma levels of a somatostatin analogue entrapped in PLA/PLGA microspheres. Journal of Controlled Release 96:3, pages 437-448.
Crossref
Sergio Freitas, Hans Peter Merkle & Bruno Gander. (2004) Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation. Journal of Controlled Release 95:2, pages 185-195.
Crossref
F. Schönfeld, V. Hessel & C. Hofmann. (2004) An optimised split-and-recombine micro-mixer with uniform ‘chaotic’ mixing. Lab Chip 4:1, pages 65-69.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.