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Original Article

Ultrasonic atomization and subsequent polymer desolvation for peptide and protein microencapsulation into biodegradable polyesters

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Pages 553-567 | Received 14 Jul 2002, Accepted 12 Jan 2003, Published online: 02 Jul 2010

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Hongyi Ouyang, Soon Jun Ang, Zong Yang Lee, Tze Ning Hiew, Paul Wan Sia Heng & Lai Wah Chan. (2022) Effect of drug load and lipid–wax blends on drug release and stability from spray-congealed microparticles. Pharmaceutical Development and Technology 27:10, pages 1069-1082.
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Nadiah Zafar, Geraldine Agusti, Hatem Fessi & Abdelhamid Elaissari. (2017) Elaboration of sponge-like biodegradable cationic particles via double-emulsion solvent evaporation. Journal of Dispersion Science and Technology 38:4, pages 577-583.
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Priscilla Chui Hong Wong, Paul Wan Sia Heng & Lai Wah Chan. (2016) A study on the solid state characteristics of spray-congealed glyceryl dibehenate solid lipid microparticles containing ibuprofen. Drug Development and Industrial Pharmacy 42:3, pages 364-377.
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Ravi Vaishya, Varun Khurana, Sulabh Patel & Ashim K Mitra. (2015) Long-term delivery of protein therapeutics. Expert Opinion on Drug Delivery 12:3, pages 415-440.
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Ching Mien Oh, Qiyun Guo, Paul Wan Sia Heng & Lai Wah Chan. (2014) Spray-congealed microparticles for drug delivery – an overview of factors influencing their production and characteristics. Expert Opinion on Drug Delivery 11:7, pages 1047-1060.
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Jeeyoung Jang & Hongkee Sah. (2011) Nonhalogenated solvent-based solvent evaporation process useful in preparation of PLGA microspheres. Journal of Microencapsulation 28:6, pages 490-498.
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G. X. Wang, L. L. Luo, T. Y. Yin, Y. Li, T. Jiang, C. G. Ruan, R. Guidoin, Y. P. Chen & R. Guzman. (2010) Ultrasonic atomization and subsequent desolvation for monoclonal antibody (mAb) to the glycoprotein (GP) IIIa receptor into drug eluting stent. Journal of Microencapsulation 27:2, pages 105-114.
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Richard A. Graves, Daniel Poole, Raisa Moiseyev, Levon A. Bostanian & Tarun K. Mandal. (2008) Encapsulation of Indomethacin Using Coaxial Ultrasonic Atomization Followed by Solvent Evaporation. Drug Development and Industrial Pharmacy 34:4, pages 419-426.
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Michael B. Mackaplow, Isidro E. Zarraga & Jeffrey F. Morris. (2006) Rotary spray congealing of a suspension: Effect of disk speed and dispersed particle properties. Journal of Microencapsulation 23:7, pages 793-809.
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Yixiang Xu, Maciej Skotak & Milford Hanna. (2006) Electrospray encapsulation of water-soluble protein with polylactide. I. Effects of formulations and process on morphology and particle size. Journal of Microencapsulation 23:1, pages 69-78.
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. (2004) Literature Alerts. Journal of Microencapsulation 21:1, pages 113-122.
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Jafar Hajavi, Mahboubeh Ebrahimian, Mojtaba Sankian, Mohammad Reza Khakzad & Maryam Hashemi. (2018) Optimization of PLGA formulation containing protein or peptide‐based antigen: Recent advances. Journal of Biomedical Materials Research Part A 106:9, pages 2540-2551.
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Hongyi Ouyang, Audrey Zheng, Paul Heng & Lai Chan. (2018) Effect of Lipid Additives and Drug on the Rheological Properties of Molten Paraffin Wax, Degree of Surface Drug Coating, and Drug Release in Spray-Congealed Microparticles. Pharmaceutics 10:3, pages 75.
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Mazhar Ul‐Islam, Shaukat Khan, Muhammad Wajid Ullah & Joong Kon Park. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 517 540 .
Priscilla Chui Hong Wong, Paul Wan Sia Heng & Lai Wah Chan. (2015) Determination of Solid State Characteristics of Spray-Congealed Ibuprofen Solid Lipid Microparticles and Their Impact on Sustaining Drug Release. Molecular Pharmaceutics 12:5, pages 1592-1604.
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James Friend & Leslie Y. Yeo. (2011) Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics. Reviews of Modern Physics 83:2, pages 647-704.
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Shunmugaperumal Tamilvanan. 2010. Pharmaceutical Sciences Encyclopedia. Pharmaceutical Sciences Encyclopedia 1 49 .
Jenny Ho, Yi Huang, Michael K. Danquah, Huanting Wang & Gareth M. Forde. (2010) Synthesis of biodegradable polymer–mesoporous silica composite microspheres for DNA prime-protein boost vaccination. European Journal of Pharmaceutical Sciences 39:5, pages 412-420.
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Beatrice Albertini, Nadia Passerini & Lorenzo Rodriguez. (2005) Evaluation of ultrasonic atomization as a new approach to prepare ionically cross-linked chitosan microparticles. Journal of Pharmacy and Pharmacology 57:7, pages 821-829.
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John R. Eisenbrey, Jennifer Hsu & Margaret A. Wheatley. (2009) Plasma Sterilization of Poly Lactic Acid Ultrasound Contrast Agents: Surface Modification and Implications for Drug Delivery. Ultrasound in Medicine & Biology 35:11, pages 1854-1862.
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Michael T. Kennedy, Alana Ali-Reynolds, Christina Farrier & Paul A. Burke. (2008) Atomizing into a Chilled Extraction Solvent Eliminates Liquid Gas from a Spray-Freeze Drying Microencapsulation Process. Journal of Pharmaceutical Sciences 97:10, pages 4459-4472.
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Jenny Ho, Huanting Wang & Gareth M. Forde. (2008) Process considerations related to the microencapsulation of plasmid DNA via ultrasonic atomization. Biotechnology and Bioengineering 101:1, pages 172-181.
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Verónica Lassalle & María Luján Ferreira. (2007) PLA Nano- and Microparticles for Drug Delivery: An Overview of the Methods of Preparation. Macromolecular Bioscience 7:6, pages 767-783.
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Gareth Forde, James Friend & Tom Williamson. (2006) Straightforward biodegradable nanoparticle generation through megahertz-order ultrasonic atomization. Applied Physics Letters 89:6, pages 064105.
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G.M. Forde, A.D. Coomes, F.K. Giliam, Y. Han & M.J. Horsfall. (2006) Creation of Protein Loaded Biodegradable Microparticles via Ultrasonic Atomization Suitable for Nasal Delivery. Chemical Engineering Research and Design 84:3, pages 178-184.
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J. Park, M. Ye & K. Park. (2005) Biodegradable Polymers for Microencapsulation of Drugs. Molecules 10:1, pages 146-161.
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Sergio Freitas, Hans Peter Merkle & Bruno Gander. (2004) Ultrasonic atomisation into reduced pressure atmosphere—envisaging aseptic spray-drying for microencapsulation. Journal of Controlled Release 95:2, pages 185-195.
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