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Journal of Microencapsulation
Micro and Nano Carriers
Volume 30, 2013 - Issue 1
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Research Article

Formulation of meningococcal capsular polysaccharide vaccine-loaded microparticles with robust innate immune recognition

Ruhi V. UbaleDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
,
Martin J. D'souzaDepartment of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, Mercer University, Atlanta, GA 30341, USA
,
Daniel T. InfieldDepartment of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Emory+Children's Center for Cystic Fibrosis Research, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA
,
Nael A. McCartyDepartment of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Emory+Children's Center for Cystic Fibrosis Research, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30322, USA
&
Susu M. ZughaierDepartment of Pediatrics, Division of Pulmonology, Allergy/Immunology, Cystic Fibrosis and Sleep, Emory+Children's Center for Cystic Fibrosis Research, Emory University School of Medicine and Children's Healthcare of Atlanta, Atlanta, GA 30322, USACorrespondence[email protected]
Pages 28-41 | Received 31 Jan 2012, Accepted 23 Apr 2012, Published online: 01 Jun 2012

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Yizhi Qi & Christopher B. Fox. (2021) Development of thermostable vaccine adjuvants. Expert Review of Vaccines 20:5, pages 497-517.
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Gaurav Kanojia, Rimko ten Have, Peter C. Soema, Henderik Frijlink, Jean-Pierre Amorij & Gideon Kersten. (2017) Developments in the formulation and delivery of spray dried vaccines. Human Vaccines & Immunotherapeutics 13:10, pages 2364-2378.
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Susu M. Zughaier. (2017) Analysis of novel meningococcal vaccine formulations. Human Vaccines & Immunotherapeutics 13:7, pages 1728-1732.
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Articles from other publishers (20)

Priyal Bagwe, Lotika Bajaj, Ipshita Menon, Keegan Braz Gomes, Akanksha Kale, Smital Patil, Sharon Vijayanand, Rikhav Gala, Martin J. D'Souza & Susu M. Zughaier. (2023) Gonococcal microparticle vaccine in dissolving microneedles induced immunity and enhanced bacterial clearance in infected mice. International Journal of Pharmaceutics 642, pages 123182.
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Nihal Mulla, Lipika Chablani, Ashwin C. Parenky & Martin J. D’Souza. (2023) Boosting In-Vivo Anti-Tumor Immunity with an Oral Microparticulate Breast Cancer Vaccine and Low-Dose Cyclophosphamide. Vaccines 11:3, pages 543.
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Ipshita Menon, Sang Moo Kang, Keegan Braz Gomes, Mohammad N. Uddin & Martin D'Souza. (2023) Laser-assisted intradermal delivery of a microparticle vaccine for respiratory syncytial virus induces a robust immune response. Vaccine 41:6, pages 1209-1222.
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Cordin ArpagausCordin Arpagaus. 2023. Spray Drying of Vaccines. Spray Drying of Vaccines 531 589 .
Cordin ArpagausCordin Arpagaus. 2023. Spray Drying of Vaccines. Spray Drying of Vaccines 325 530 .
Keegan Braz Gomes, Ipshita Menon, Priyal Bagwe, Lotika Bajaj, Sang-Moo Kang & Martin J. D’Souza. (2022) Enhanced Immunogenicity of an Influenza Ectodomain Matrix-2 Protein Virus-like Particle (M2e VLP) Using Polymeric Microparticles for Vaccine Delivery. Viruses 14:9, pages 1920.
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Ipshita Menon, Sang Moo Kang & Martin D'Souza. (2022) Nanoparticle formulation of the fusion protein virus like particles of respiratory syncytial virus stimulates enhanced in vitro antigen presentation and autophagy. International Journal of Pharmaceutics 623, pages 121919.
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Priyal Bagwe, Lotika Bajaj, Rikhav P. Gala, Martin J. D‘Souza & Susu M. Zughaier. (2022) Assessment of In Vitro Immunostimulatory Activity of an Adjuvanted Whole-Cell Inactivated Neisseria gonorrhoeae Microparticle Vaccine Formulation. Vaccines 10:7, pages 983.
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Valeria Trincado, Rikhav P. Gala & Javier O. Morales. (2021) Buccal and Sublingual Vaccines: A Review on Oral Mucosal Immunization and Delivery Systems. Vaccines 9:10, pages 1177.
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Laura Morelli, Laura Polito, Barbara Richichi & Federica Compostella. (2021) Glyconanoparticles as tools to prevent antimicrobial resistance. Glycoconjugate Journal 38:4, pages 475-490.
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Kendall B. Preston & Theodore W. Randolph. (2021) Stability of lyophilized and spray dried vaccine formulations. Advanced Drug Delivery Reviews 171, pages 50-61.
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Rikhav Gala, Rokon Zaman, Martin D’Souza & Susu Zughaier. (2018) Novel Whole-Cell Inactivated Neisseria Gonorrhoeae Microparticles as Vaccine Formulation in Microneedle-Based Transdermal Immunization. Vaccines 6:3, pages 60.
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Ruhi V. Ubale, Prathap Nagaraja Shastri, Carl Oettinger & Martin J. D’Souza. (2018) Pulmonary Administration of Microparticulate Antisense Oligonucleotide (ASO) for the Treatment of Lung Inflammation. AAPS PharmSciTech 19:4, pages 1908-1919.
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Rikhav P. Gala, Carmen Popescu, Gregory T. Knipp, Robyn R. McCain, Ruhi V. Ubale, Richard Addo, Tuhin Bhowmik, Christopher D. Kulczar & Martin J. D’Souza. (2016) Physicochemical and Preclinical Evaluation of a Novel Buccal Measles Vaccine. AAPS PharmSciTech 18:2, pages 283-292.
Crossref
Xiaorui Zhang, Chunhui Qi, Yan Guo, Wenxia Zhou & Yongxiang Zhang. (2016) Toll-like receptor 4-related immunostimulatory polysaccharides: Primary structure, activity relationships, and possible interaction models. Carbohydrate Polymers 149, pages 186-206.
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Rikhav P. Gala, Martin D'Souza & Susu M. Zughaier. (2016) Evaluation of various adjuvant nanoparticulate formulations for meningococcal capsular polysaccharide-based vaccine. Vaccine 34:28, pages 3260-3267.
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Susu M. Zughaier, Justin L. Kandler, Jacqueline T. Balthazar & William M. Shafer. (2015) Phosphoethanolamine Modification of Neisseria gonorrhoeae Lipid A Reduces Autophagy Flux in Macrophages. PLOS ONE 10:12, pages e0144347.
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Martin J. D’Souza, Rikhav P. Gala, Ruhi V. Ubale, Bernadette D’Souza, Trinh Phuong Vo, Ashwin C. Parenky, Nihal S. Mulla, Sucheta D’Sa, Marissa D’Souza, Kim Braz-Gomes, Nigel D’Souza, Maurizio Chiriva-Internati & Susu Zughaier. 2015. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies. Novel Approaches and Strategies for Biologics, Vaccines and Cancer Therapies 89 122 .
Ruhi V. Ubale, Rikhav P. Gala, Susu M. Zughaier & Martin J. D’Souza. (2014) Induction of Death Receptor CD95 and Co-stimulatory Molecules CD80 and CD86 by Meningococcal Capsular Polysaccharide-Loaded Vaccine Nanoparticles. The AAPS Journal 16:5, pages 986-993.
Crossref
Jesus Colino, Leah Duke & Clifford M. Snapper. (2013) Noncovalent Association of Protein and Capsular Polysaccharide on Bacteria-Sized Latex Beads as a Model for Polysaccharide-Specific Humoral Immunity to Intact Gram-Positive Extracellular Bacteria. The Journal of Immunology 191:6, pages 3254-3263.
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