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Research Article

A novel solid dispersion system for natural product-loaded medicine: silymarin-loaded solid dispersion with enhanced oral bioavailability and hepatoprotective activity

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Pages 619-626 | Received 30 Jul 2013, Accepted 17 Mar 2014, Published online: 25 Apr 2014

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Seyed Reza Mokhtari Sangdehi, Akbar Hajizadeh Moghaddam & Mojtaba Ranjbar. (2022) Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury. International Journal of Neuroscience 132:11, pages 1102-1109.
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Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee & Feng-Lin Yen. (2018) Preparation, characterizations and anti-pollutant activity of 7,3′,4′-trihydroxyisoflavone nanoparticles in particulate matter-induced HaCaT keratinocytes. International Journal of Nanomedicine 13, pages 3279-3293.
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Sabyasachi Banerjee, K. Ravi Shankar & Rajendra Prasad Y.. (2016) Formulation development and systematic optimization of stabilized ziprasidone hydrochloride capsules devoid of any food effect. Pharmaceutical Development and Technology 21:7, pages 775-786.
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Gang Yang, Yaping Zhao, Yongtai Zhang, Beilei Dang, Ying Liu & Nianping Feng. (2015) Enhanced oral bioavailability of silymarin using liposomes containing a bile salt: preparation by supercritical fluid technology and evaluation in vitro and in vivo. International Journal of Nanomedicine 10, pages 6633-6644.
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Articles from other publishers (23)

Fai A. Alkathiri, Sarah I. Bukhari, Syed Sarim Imam, Sultan Alshehri & Wael A. Mahdi. (2024) Formulation of silymarin binary and ternary solid dispersions: Characterization, simulation study and cell viability assessment against lung cancer cell line. Heliyon 10:1, pages e23221.
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Debadatta Mohapatra, Dulla Naveen Kumar, Singh Shreya, Vivek Pandey, Pawan K. Dubey, Ashish Kumar Agrawal & Alakh N Sahu. (2023) Quality by design–based development and optimization of fourth-generation ternary solid dispersion of standardized Piper longum extract for melanoma therapy. Drug Delivery and Translational Research 13:12, pages 3094-3131.
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Shovit Ranjan & Akash Gautam. (2023) Pharmaceutical prospects of Silymarin for the treatment of neurological patients: an updated insight. Frontiers in Neuroscience 17.
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Yuan Zhu, Shuang Li, Haiqiao Wang, Michael Adu‐Frimpong, Yuanyuan Xue, Zhengqing Gu, Jiangnan Yu & Ximing Xu. (2023) Enhanced oral bioavailability of capsaicin‐loaded microencapsulation complex via electrospray technology: Preparation, in vitro and in vivo evaluation. Biopharmaceutics & Drug Disposition 44:2, pages 137-146.
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Kaushika Patel, Shreeraj Shah & Jaymin Patel. (2022) Solid dispersion technology as a formulation strategy for the fabrication of modified release dosage forms: A comprehensive review. DARU Journal of Pharmaceutical Sciences 30:1, pages 165-189.
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Sojeong Jin, Chul Haeng Lee, Dong Yu Lim, Jaehyeok Lee, Soo-Jin Park, Im-Sook Song & Min-Koo Choi. (2021) Improved Hygroscopicity and Bioavailability of Solid Dispersion of Red Ginseng Extract with Silicon Dioxide. Pharmaceutics 13:7, pages 1022.
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Václav Tvrdý, Jana Pourová, Eduard Jirkovský, Vladimír Křen, Kateřina Valentová & Přemysl Mladěnka. (2021) Systematic review of pharmacokinetics and potential pharmacokinetic interactions of flavonolignans from silymarin. Medicinal Research Reviews 41:4, pages 2195-2246.
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Im-Sook Song, So-Jeong Nam, Ji-Hyeon Jeon, Soo-Jin Park & Min-Koo Choi. (2021) Enhanced Bioavailability and Efficacy of Silymarin Solid Dispersion in Rats with Acetaminophen-Induced Hepatotoxicity. Pharmaceutics 13:5, pages 628.
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Shanza Mukhtar, Zeng Xiaoxiong, Samina Qamer, Muhammad Saad, Muhammad Samee Mubarik, Ahmed Hossam Mahmoud & Osama B. Mohammed. (2021) Hepatoprotective activity of silymarin encapsulation against hepatic damage in albino rats. Saudi Journal of Biological Sciences 28:1, pages 717-723.
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Verônica da Silva Oliveira, Amanda Silva de Almeida, Ingrid da Silva Albuquerque, Fernanda Ílary Costa Duarte, Bárbara Cristina Silva Holanda Queiroz, Attilio Converti & Ádley Antonini Neves de Lima. (2020) Therapeutic Applications of Solid Dispersions for Drugs and New Molecules: In Vitro and In Vivo Activities. Pharmaceutics 12:10, pages 933.
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V. Dhawan, B. Sutariya, A. Lokras, J. Thamm, M. Saraf, U. Warawdekar, A. Fahr & M. Nagarsenker. (2020) Lipid nanoconstructs for superior hepatoprotection: In vitro assessments as predictive tool for in vivo translation. International Journal of Pharmaceutics 579, pages 119176.
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Alfonso Di Costanzo & Ruggero Angelico. (2019) Formulation Strategies for Enhancing the Bioavailability of Silymarin: The State of the Art. Molecules 24:11, pages 2155.
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Abid Mehmood Yousaf, Usman Rashid Malik, Yasser Shahzad, Tariq Mahmood & Talib Hussain. (2019) Silymarin-laden PVP-PEG polymeric composite for enhanced aqueous solubility and dissolution rate: Preparation and in vitro characterization. Journal of Pharmaceutical Analysis 9:1, pages 34-39.
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Nguyen-Thach Tung, Cao-Son Tran, Hoang-Anh Nguyen, Thuy-Duong Nguyen, Sang-Cheol Chi, Duc-Vinh Pham, Quang-Dong Bui & Xuan-Hoang Ho. (2019) Formulation and biopharmaceutical evaluation of supersaturatable self-nanoemulsifying drug delivery systems containing silymarin. International Journal of Pharmaceutics 555, pages 63-76.
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Aziz Eftekhari, Solmaz Maleki Dizaj, Leila Chodari, Senem Sunar, Amir Hasanzadeh, Elham Ahmadian & Mohammad Hasanzadeh. (2018) The promising future of nano-antioxidant therapy against environmental pollutants induced-toxicities. Biomedicine & Pharmacotherapy 103, pages 1018-1027.
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Hammad Ullah & Haroon Khan. (2018) Anti-Parkinson Potential of Silymarin: Mechanistic Insight and Therapeutic Standing. Frontiers in Pharmacology 9.
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Michal Bijak, Rafal Szelenberger, Angela Dziedzic & Joanna Saluk-Bijak. (2018) Inhibitory Effect of Flavonolignans on the P2Y12 Pathway in Blood Platelets. Molecules 23:2, pages 374.
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Michal Bijak, Ewelina Synowiec, Przemyslaw Sitarek, Tomasz Sliwiński & Joanna Saluk-Bijak. (2017) Evaluation of the Cytotoxicity and Genotoxicity of Flavonolignans in Different Cellular Models. Nutrients 9:12, pages 1356.
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Michal Bijak. (2017) Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)—Chemistry, Bioavailability, and Metabolism. Molecules 22:11, pages 1942.
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Raj Kumar Thapa, Han-Gon Choi, Jong Oh Kim & Chul Soon Yong. (2017) Analysis and optimization of drug solubility to improve pharmacokinetics. Journal of Pharmaceutical Investigation 47:2, pages 95-110.
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Jin Cheul Kim, Kyeong Soo Kim, Dong Shik Kim, Sung Giu Jin, Dong Wuk Kim, Yong Il Kim, Jae-Hyun Park, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Jong Soo Woo & Han-Gon Choi. (2016) Effect of HM30181 mesylate salt-loaded microcapsules on the oral absorption of paclitaxel as a novel P-glycoprotein inhibitor. International Journal of Pharmaceutics 506:1-2, pages 93-101.
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Robert Domitrović & Iva Potočnjak. (2015) A comprehensive overview of hepatoprotective natural compounds: mechanism of action and clinical perspectives. Archives of Toxicology 90:1, pages 39-79.
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Manish Adhikari & Rajesh Arora. (2015) Nano-silymarin provides protection against γ-radiation-induced oxidative stress in cultured human embryonic kidney cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 792, pages 1-11.
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