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Research Article

Eudragit RS and RL (acrylic resins) microcapsules as pH insensitive and sustained release preparations of ketoprofen

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Pages 293-304 | Received 07 Jun 1986, Accepted 13 Jun 1986, Published online: 27 Sep 2008

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Armin Mooranian, Thomas Foster, Corina M Ionescu, Louise Carey, Daniel Walker, Melissa Jones, Susbin Raj Wagle, Bozica Kovacevic, Jacqueline Chester, Edan Johnstone, Jafri Kuthubutheen, Daniel Brown, Marcus D Atlas, Momir Mikov & Hani Al-Salami. (2021) The Effects of Primary Unconjugated Bile Acids on Nanoencapsulated Pharmaceutical Formulation of Hydrophilic Drugs: Pharmacological Implications. Drug Design, Development and Therapy 15, pages 4423-4434.
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CláudiaR. F. Souza & WanderleyP. Oliveira. (2012) Microencapsulation of Ketoprofen in Blends of Acrylic Resins by Spray Drying. Drying Technology 30:3, pages 263-275.
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Mitra Jelvehgari, Jaleh Barar, Hadi Valizadeh, Sanam Shadrou & Ali Nokhodchi. (2011) Formulation, characterization and in vitro evaluation of theophylline-loaded Eudragit RS 100 microspheres prepared by an emulsion-solvent diffusion/evaporation technique. Pharmaceutical Development and Technology 16:6, pages 637-644.
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Giovanna Rassu, Elisabetta Gavini, Gianpiera Spada, Paolo Giunchedi & Salvatore Marceddu. (2008) Ketoprofen Spray-dried Microspheres Based on Eudragit® RS and RL: Study of the Manufacturing Parameters. Drug Development and Industrial Pharmacy 34:11, pages 1178-1187.
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S. Bhaskaran & S. Suresh. (2004) Biodegradable microspheres of ketorolac tromethamine for parenteral administration. Journal of Microencapsulation 21:7, pages 743-750.
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Rosario Pignatello, Daniela Spadaro, Maria Angela Vandelli, Flavio Forni & Giovanni Puglisi. (2004) Characterization of the Mechanism of Interaction in Ibuprofen‐Eudragit RL100® Coevaporates. Drug Development and Industrial Pharmacy 30:3, pages 277-288.
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E. Squillante, G. Morshed, S. Bagchi & K. A. Mehta. (2003) Microencapsulation of β-galactosidase with Eudragit L-100. Journal of Microencapsulation 20:2, pages 153-167.
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Z. G. Gao, K. H. Oh & C.-K Kim. (1998) Preparation and characterization of sustained-release microspheres of chlorpromazine. Journal of Microencapsulation 15:1, pages 75-83.
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S. Venkataram & M. Khohlokwane. (1996) Microencapsulation of an iron chelator for sustained release and crystal habit modification. Journal of Microencapsulation 13:5, pages 519-525.
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I. El-Gibaly, S. M. Safwat & M. O. Ahmed. (1996) Microencapsulation of ketoprofen using w/o/w complex emulsion technique. Journal of Microencapsulation 13:1, pages 67-87.
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N. Saha & T. K. Pal. (1995) Preparation of ranitidine hydrochloride microcapsules and its biphasic release kinetics. Drug Delivery 2:3-4, pages 215-220.
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Y. Kawashima, T. Iwamoto, T. Niwa, H. Takeuchi & T. Hino. (1993) Role of the solvent-diffusion-rate modifier in a new emulsion solvent diffusion method for preparation of ketoprofen microspheres. Journal of Microencapsulation 10:3, pages 329-340.
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M. Bogataj, A. Mrhar, A. Kristl & F. Kozjek. (1991) Eudragit E microspheres containing bacampicillin: Preparation by solvent removal methods. Journal of Microencapsulation 8:3, pages 401-406.
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M. Dittrich & L. Melichar. (1990) A contribution to the evaluation of microcapsules by light microscopy. Journal of Microencapsulation 7:4, pages 527-540.
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M. Bogataj, A. Mrhar, A. Kristl & F. Kozjek. (1989) Preparation and Evaluation of Eudragit E Microspheres Containing Bacampicillin. Drug Development and Industrial Pharmacy 15:14-16, pages 2295-2313.
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Shigeru Goto, Masakazu Kawata, Masahiro Nakamura, Yoshiko Nagatsuma, Keiko Fujinaga & Toshinobu Aoyama. (1988) Evaluation of the sustained release properties of Eudragit RS, RL and S (acrylic resins) microcapsules containing ketoprofen in beagle dogs˚. Journal of Microencapsulation 5:4, pages 343-360.
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Shigeru Goto, Masakazu Kawata, Masahiro Nakamura, Kaori Maekawa & Toshinobu Aoyama. (1986) Eudragit E, L and S (acrylic resins) microcapsules as pH sensitive release preparations of ketoprofen. Journal of Microencapsulation 3:4, pages 305-316.
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Christianne Mounir Zaki Rizkalla, Randa latif Aziz & Iman Ibrahim Soliman. (2011) In Vitro and In Vivo Evaluation of Hydroxyzine Hydrochloride Microsponges for Topical Delivery. AAPS PharmSciTech 12:3, pages 989-1001.
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Pao-Chu Wu, Yaw-Bin Huang, Jui-Sheng Chang, Ming-Jun Tsai & Yi-Hung Tsai. (2003) Design and evaluation of sustained release microspheres of potassium chloride prepared by Eudragit®. European Journal of Pharmaceutical Sciences 19:2-3, pages 115-122.
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R. Pignatello, C. Bucolo & G. Puglisi. (2002) Ocular Tolerability of Eudragit RS100® and RL100® Nanosuspensions as Carriers for Ophthalmic Controlled Drug Delivery. Journal of Pharmaceutical Sciences 91:12, pages 2636-2641.
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Rosario Pignatello, Marinella Ferro & Giovanni Puglisi. (2002) Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions. AAPS PharmSciTech 3:2, pages 35-45.
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Francesco Castelli, Chiara Messina, Maria Grazia Sarpietro, Rosario Pignatello & Giovanni Puglisi. (2002) Flurbiprofen release from eudragit RS and RL aqueous nanosuspensions: a kinetic study by DSC and dialysis experiments. AAPS PharmSciTech 3:2, pages 26-33.
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A. Ribardière, P. Tchoreloff, G. Couarraze & F. Puisieux. (1996) Modification of ketoprofen bead structure produced by the spherical crystallization technique with a two-solvent system. International Journal of Pharmaceutics 144:2, pages 195-207.
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Kim Chong-Kook, Kim Mi-Jung & Oh Kyoung-Hee. (1994) Preparation and evaluation of sustained release microspheres of terbutaline sulfate. International Journal of Pharmaceutics 106:3, pages 213-219.
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Sang-Chul Shin & Keong-Ran Lee. (1993) Studies on the development for sustained release preparation (II): Preparation and evaluation of eudragit microcapsules of sodium naproxen. Archives of Pharmacal Research 16:1, pages 50-56.
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Burkhard Wichert & Peter Rohdewald. (1990) A new method for the preparation of drug containing polylactic acid microparticles without using organic solvents. Journal of Controlled Release 14:3, pages 269-283.
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Reza Arshady. (2004) Microspheres and microcapsules, a survey of manufacturing techniques: Part III: Solvent evaporation. Polymer Engineering & Science 30:15, pages 915-924.
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