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Journal of Microencapsulation
Micro and Nano Carriers
Volume 5, 1988 - Issue 1
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Research Article

The antitumour effect of lipophilic derivatives of 5-fluoro-2'-deoxyuridine incorporated into liposomes

A. Supersaxo Pharmaceutical Institute, Department of Physical Pharmacy, Swiss Federal Institute of Technology ETH, CH-8092, Zürich, Switzerland
,
W. Rubas Pharmaceutical Institute, Department of Physical Pharmacy, Swiss Federal Institute of Technology ETH, CH-8092, Zürich, Switzerland
,
H. R. Hartmann F. Hoffmann-La Roche, Pharmaceutical Research Department, CH-4002, Basel, Switzerland
,
H. Schott Institute of Organic Chemistry, University of Tübingen, Tübingen, FR, Germany
,
H. Hengartner Institute of Pathology, Experimental Pathology, University Hospital, CH-8091, Zürich, Switzerland
&
R. A. Schwendener Institute of Pathology, Experimental Pathology, University Hospital, CH-8091, Zürich, Switzerland
Pages 1-11 | Received 16 Jan 1987, Accepted 09 Mar 1987, Published online: 27 Sep 2008

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M. Van Borssum Waalkes, I. Fichtner, B. Dontje, M. Lemm, M. Becker, D. Arndt & G. L. Scherphof. (1992) In vivo distribution and antitumour activity of liposomal 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine. Journal of Microencapsulation 9:3, pages 335-346.
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Articles from other publishers (10)

Reto Schwendener & Herbert Schott. 2006. Liposome Technology, Volume II. Liposome Technology, Volume II 51 62 .
Sophie Glatt, Eliane Fuseau, Mauro Buraglio & Quyen T X Nguyen. (2005) Population Pharmacokinetics of Onercept in Healthy Subjects. Clinical Pharmacokinetics 44:12, pages 1295-1304.
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G A Koning, A Gorter, G L Scherphof & J A A M Kamps. (1999) Antiproliferative effect of immunoliposomes containing 5-fluorodeoxyuridine-dipalmitate on colon cancer cells. British Journal of Cancer 80:11, pages 1718-1725.
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Monica Gulati, Manish Grover, Saranjit Singh & Mandip Singh. (1998) Lipophilic drug derivatives in liposomes. International Journal of Pharmaceutics 165:2, pages 129-168.
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Paola Crosasso, Paola Brusa, Franco Dosio, Silvia Arpicco, Donatella Pacchioni, Francis Schuberî & Luigi Cattel. (1997) Antitumoral Activity of Liposomes and Immunoliposomes Containing 5-Fluorouridine Prodrugs. Journal of Pharmaceutical Sciences 86:7, pages 832-839.
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Atsuhide Mori, Stephen J. Kennel, Marjan van Borssum Waalkes, Gerrit L. Scherphof & Leaf Huang. (1995) Characterization of organ-specific immunoliposomes for delivery of 3′,5′-O-dipalmitoyl-5-fluoro-2′-deoxyuridine in a mouse lung-metastasis model. Cancer Chemotherapy and Pharmacology 35:6, pages 447-456.
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Marjan van Borssum Waalkes, Mieke van Galen, Henriëtte Morselt, Brigitte Sternberg & Gerrit L. Scherphof. (1993) In-vitro stability and cytostatic activity of liposomal formulations of 5-fluoro-2′-deoxyuridine and its diacylated derivatives. Biochimica et Biophysica Acta (BBA) - Biomembranes 1148:1, pages 161-172.
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Marjan van Borssum Waalkes, Folkert Kuipers, Rick Havinga & Gerrit L. Scherphof. (1993) Conversion of liposomal 5-fluoro-2′-deoxyuridine and its dipalmitoyl derivative to bile acid conjugates of α-fluoro-β-alanine and their excretion into rat bile. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1176:1-2, pages 43-50.
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Reto A. Schwendener, Heinz H. Fiebig, Martin R. Berger & Dietmar P. Berger. (1991) Evaluation of incorporation characteristics of mitoxantrone into unilamellar liposomes and analysis of their pharmacokinetic properties, acute toxicity, and antitumor efficacy. Cancer Chemotherapy and Pharmacology 27:6, pages 429-439.
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R. A. Schwendener. (1988) Incorporation of chlorpromazine into bilayer liposomes for protection against microsomal metabolism and liver absorption. European Journal of Drug Metabolism and Pharmacokinetics 13:2, pages 135-141.
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