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Research Article

In vitro and in vivo antitumoral activity of free, and encapsulated taxol

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Pages 191-197 | Received 19 Jul 1989, Accepted 04 Aug 1989, Published online: 27 Sep 2008

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Minzhi Zhao, Haiyun Li, Linyang Fan, Yan Ma, He Gong, Wenjia Lai, Qiaojun Fang & Zhiyuan Hu. (2018) Quantitative proteomic analysis to the first commercialized liposomal paclitaxel nano-platform Lipusu revealed the molecular mechanism of the enhanced anti-tumor effect. Artificial Cells, Nanomedicine, and Biotechnology 46:sup3, pages 147-155.
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Mohammad Sadegh Amini-Fazl, Hamid Mobedi & Jalal Barzin. (2014) Investigation of aqueous stability of taxol in different release media. Drug Development and Industrial Pharmacy 40:4, pages 519-526.
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P. López-Gasco, I. Iglesias, J. Benedí, R. Lozano, J.M. Teijón & M.D. Blanco. (2011) Paclitaxel-loaded polyester nanoparticles prepared by spray-drying technology: in vitro bioactivity evaluation. Journal of Microencapsulation 28:5, pages 417-429.
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Utsana Puapermpoonsiri, Vimolmas Lipipun & Nontima Vardhanabhuti. (2005) Synergistic Effect of Phospholipid-Based Liposomes and Propylthiouracil on U-937 Cell Growth. Journal of Liposome Research 15:3-4, pages 215-227.
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Songnian Lin & Iwao Ojima. (2000) Recent strategies in the development of taxane anticancer drugs. Expert Opinion on Therapeutic Patents 10:6, pages 869-889.
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F. Sampedro, J. Partika, P. Santalo, A. M. Molins-Pujol, J. Bonal & R. Perez-Soler. (1994) Liposomes as carriers of different new lipophilic antitumour drugs: A preliminary report. Journal of Microencapsulation 11:3, pages 309-318.
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C. Bottex-Gauthier, F. Condemine, F. Picot & D. Vidal. (1992) Effects of Taxol on the Macrophage Function. Interactions with Some Immunological Parameters. Immunopharmacology and Immunotoxicology 14:1-2, pages 39-61.
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Lei Lei, Xiao-Jia Wang & Shou-Ching Tang. (2022) Novel taxanes in development: Hopes or hypes?. Critical Reviews in Oncology/Hematology 176, pages 103727.
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Mei Lu, Xiaoyun Zhao, Haonan Xing, Zhe Xun, Shimeng Zhu, Lang Lang, Tianzhi Yang, Cuifang Cai, Dongkai Wang & Pingtian Ding. (2018) Comparison of exosome-mimicking liposomes with conventional liposomes for intracellular delivery of siRNA. International Journal of Pharmaceutics 550:1-2, pages 100-113.
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Ana Filipa Cruz, Nuno A. Fonseca, Ana C. Gregório, Vera Moura, Sérgio Simões & João Nuno Moreira. 2018. Particles and Nanoparticles in Pharmaceutical Products. Particles and Nanoparticles in Pharmaceutical Products 171 211 .
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Lan Feng & Russell J. Mumper. (2013) A critical review of lipid-based nanoparticles for taxane delivery. Cancer Letters 334:2, pages 157-175.
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Pei Kan, Chih-Wan Tsao, Ae-June Wang, Wu-Chou Su & Hsiang-Fa Liang. (2011) A Liposomal Formulation Able to Incorporate a High Content of Paclitaxel and Exert Promising Anticancer Effect. Journal of Drug Delivery 2011, pages 1-9.
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Qizhen Cao, Zi-Bo Li, Kai Chen, Zhanhong Wu, Lina He, Nouri Neamati & Xiaoyuan Chen. (2008) Evaluation of biodistribution and anti-tumor effect of a dimeric RGD peptide–paclitaxel conjugate in mice with breast cancer. European Journal of Nuclear Medicine and Molecular Imaging 35:8, pages 1489-1498.
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Seong-Cheol Bang, Ji-Hyun LeeGyu-Yong Song, Dong-Hee Kim, Mi-Young Yoon & Byung-Zun Ahn. (2005) Antitumor Activity of Pulsatilla koreana Saponins and Their Structure-Activity Relationship. Chemical and Pharmaceutical Bulletin 53:11, pages 1451-1454.
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D. Le Garrec, S. Gori, L. Luo, D. Lessard, D.C. Smith, M.-A. Yessine, M. Ranger & J.-C. Leroux. (2004) Poly(N-vinylpyrrolidone)-block-poly(d,l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. Journal of Controlled Release 99:1, pages 83-101.
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R.T. Liggins & H.M. Burt. (2002) Polyether–polyester diblock copolymers for the preparation of paclitaxel loaded polymeric micelle formulations. Advanced Drug Delivery Reviews 54:2, pages 191-202.
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L Mu & S.S Feng. (2001) Fabrication, characterization and in vitro release of paclitaxel (Taxol®) loaded poly (lactic-co-glycolic acid) microspheres prepared by spray drying technique with lipid/cholesterol emulsifiers. Journal of Controlled Release 76:3, pages 239-254.
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Bastiaan Nuijen, Marjan Bouma, Jan H.M. Schellens & Jos H. Beijnen. (2001) Progress in the Development of Alternative Pharmaceutical Formulations of Taxanes. Investigational New Drugs 19:2, pages 143-153.
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Sung Chul Kim, Dong Wook Kim, Yong Ho Shim, Joon Seok Bang, Hun Seung Oh, Sung Wan Kim & Min Hyo Seo. (2001) In vivo evaluation of polymeric micellar paclitaxel formulation: toxicity and efficacy. Journal of Controlled Release 72:1-3, pages 191-202.
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M.A Attawia, M.D Borden, K.M Herbert, D.S Katti, F Asrari, K.E Uhrich & C.T Laurencin. (2001) Regional drug delivery with radiation for the treatment of Ewing’s sarcoma. Journal of Controlled Release 71:2, pages 193-202.
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S. Poujol, F. Pinguet, F. Bressole, M. Boustta & M. Vert. (2016) Molecular Microencapsulation: Paclitaxel Formations in Aqueous Medium Using Hydrophobized Poly(L-Lysine Citramide Imide). Journal of Bioactive and Compatible Polymers 15:2, pages 99-114.
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Siddharth Pandey, Gary A. Baker, Maureen A. Kane & Frank V. Bright. (2016) On the Weak Intrinsic Luminescence from Paclitaxel Dissolved in Nonelectrolyte Solvents. Applied Spectroscopy 53:8, pages 991-999.
Crossref
Corinna Bernsdorff, Regina Reszka & Roland Winter. (1999) Interaction of the anticancer agent Taxol? (paclitaxel) with phospholipid bilayers. Journal of Biomedical Materials Research 46:2, pages 141-149.
Crossref
Ramesh Panchagnula. (1998) Pharmaceutical aspects of paclitaxel. International Journal of Pharmaceutics 172:1-2, pages 1-15.
Crossref
Anthony R. Scialli, Timothy B. Waterhouse, John M. Desesso, Aquilur Rahman & Gerald C. Goeringer. (1997) Protective effect of liposome encapsulation on paclitaxel developmental toxicity in the rat. Teratology 56:5, pages 305-310.
Crossref
Dorothea I. AxelWolfgang KunertChristoph GöggelmannMartin OberhoffChristian HerdegAxel KüttnerDoris H. WildBernhard R. BrehmReimer RiessenGerhard KövekerKarl R. Karsch. (1997) Paclitaxel Inhibits Arterial Smooth Muscle Cell Proliferation and Migration In Vitro and In Vivo Using Local Drug Delivery. Circulation 96:2, pages 636-645.
Crossref
William L Hunter, Helen M Burt & Lindsay Machan. (1997) Local delivery of chemotherapy: a supplement to existing cancer treatments. Advanced Drug Delivery Reviews 26:2-3, pages 199-207.
Crossref
Amarnath Sharma, Eric Mayhew, Lois Bolcsak, C. Cavanaugh, P. Harmon, Andrew Janoff & Ralph J. Bernacki. (1997) Activity of paclitaxel liposome formulations against human ovarian tumor xenografts. International Journal of Cancer 71:1, pages 103-107.
Crossref
J.M. Meerum Terwogt, B. Nuijen, W.W. Ten Bokkel Huinink & J.H. Beijnen. (1997) Alternative formulations of paclitaxel. Cancer Treatment Reviews 23:2, pages 87-95.
Crossref
Amarnath Sharma, Uma S. Sharma & Robert M. Straubinger. (1996) Paclitaxel-liposomes for intracavitary therapy of intraperitoneal P388 leukemia. Cancer Letters 107:2, pages 265-272.
Crossref
Stephen K. Dordunoo & Helen M. Burt. (1996) Solubility and stability of taxol: effects of buffers and cyclodextrins. International Journal of Pharmaceutics 133:1-2, pages 191-201.
Crossref
Amarnath Sharma, Robert M. Straubinger, Iwao Ojima & Ralph J. Bernacki. (1995) Antitumor Efficacy of Taxane Liposomes on a Human Ovarian Tumor Xenograft in Nude Mice†. Journal of Pharmaceutical Sciences 84:12, pages 1400-1404.
Crossref
Uma S. Sharma, Sathyamangalam V. Balasubramanian & Robert M. Straubinger. (1995) Pharmaceutical and Physical Properties of Paclitaxel (Taxol †) Complexes with Cyclodextrins ‡. Journal of Pharmaceutical Sciences 84:10, pages 1223-1230.
Crossref
Dolatrai M. Vyas. 1995. The Chemistry and Pharmacology of Taxol® and its Derivatives. The Chemistry and Pharmacology of Taxol® and its Derivatives 103 130 .
Helen M. Burt, John K. Jackson, Sarvjeet K. Bains, Richard T. Liggins, Ann Marie C. Oktaba, A.Larry Arsenault & William L. Hunter. (1995) Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d,l-lactic acid). Cancer Letters 88:1, pages 73-79.
Crossref
H.-J. Guchelaar, C.H.H. Ten Napel, E.G.E. de Vries & N.H. Mulder. (1994) Clinical, toxicological and pharmaceutical aspects of the antineoplastic drug taxol: A review. Clinical Oncology 6:1, pages 40-48.
Crossref
Matthew Suffness. 1993. 305 314 .

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