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Research Article

Microencapsulation using poly(DL-lactic acid) I: Effect of preparative variables on the microcapsule characteristics and release kinetics

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Pages 229-244 | Received 08 Aug 1989, Accepted 12 Sep 1989, Published online: 27 Sep 2008

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Read on this site (6)

C. Mallard, J. Coudane, I. Rault, M. Vert. (2000) In vitro delivery of a sparingly water soluble compound from PLA50 microparticles. Journal of Microencapsulation 17:1, pages 13-28.
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Rajeev Jain, Navnit H. Shah, A. Waseem Malick & Christopher T. Rhodes. (1998) Controlled Drug Delivery by Biodegradable Poly(Ester) Devices: Different Preparative Approaches. Drug Development and Industrial Pharmacy 24:8, pages 703-727.
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Yasuaki Ogawa. (1997) Injectable microcapsules prepared with biodegradable poly(α-hydroxy) acids for prolonged release of drugs. Journal of Biomaterials Science, Polymer Edition 8:5, pages 391-409.
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G. Owusu-Ababio & J. A. Rogers. (1996) Formulation and release kinetics of cephalexin monohydrate from biodegradable polymeric microspheres. Journal of Microencapsulation 13:2, pages 195-205.
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R. Jalil & J. R. Nixon. (1990) Microencapsulation using poly(DL-lactic acid) III: Effect of polymer molecular weight on the release kinetics. Journal of Microencapsulation 7:3, pages 357-374.
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Articles from other publishers (14)

Carolina Castañeda-Fernandez, Rosa María Chávez-Santos, Mayra Silva-Miranda, Clara Espitia-Pinzón, Roberto Martínez & Anna Kozina. (2022) Optimization of rifampicin encapsulation in PLGA polymeric reservoirs. International Journal of Pharmaceutics 622, pages 121844.
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J. Pradal, O. Jordan & E. Allémann. (2012) Intra-articular drug delivery for arthritis diseases: the value of extended release and targeting strategies. Journal of Drug Delivery Science and Technology 22:5, pages 409-419.
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Ming Li, Olivier Rouaud & Denis Poncelet. (2008) Microencapsulation by solvent evaporation: State of the art for process engineering approaches. International Journal of Pharmaceutics 363:1-2, pages 26-39.
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S.H. Wang, L.C. Zhang, F. Lin, X.Y. Sa, J.B. Zuo, Q.X. Shao, G.S. Chen & S. Zeng. (2005) Controlled release of levonorgestrel from biodegradable poly(d,l-lactide-co-glycolide) microspheres: In vitro and in vivo studies. International Journal of Pharmaceutics 301:1-2, pages 217-225.
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Elvire Fournier, Catherine Passirani, Nathalie Colin, Pascal Breton, Serge Sagodira & Jean-Pierre Benoit. (2004) Development of novel 5-FU-loaded poly(methylidene malonate 2.1.2)-based microspheres for the treatment of brain cancers. European Journal of Pharmaceutics and Biopharmaceutics 57:2, pages 189-197.
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B. Kamm, M. Kamm & K. Richter. (2004) Formation of aminium lactates in lactic acid fermentation preparation and characterization of 1,4‐piperazinium‐( L , L )‐dilactate obtained from L (+)‐lactic acid (part I) . Acta Biotechnologica 17:1, pages 3-18.
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Francesco Castelli, Bice Conti, Ubaldo Conte & Giovanni Puglisi. (1996) Effect of molecular weight and storage times on tolmetin release from poly-d,l-lactide microspheres to lipid model membrane. A calorimetric study. Journal of Controlled Release 40:3, pages 277-284.
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B. Gander, P. Johansen, Hô Nam-Trân & H.P. Merkle. (1996) Thermodynamic approach to protein microencapsulation into poly(D,L-lactide) by spray drying. International Journal of Pharmaceutics 129:1-2, pages 51-61.
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Joachim Herrmann & Roland Bodmeier. (1995) The effect of particle microstructure on the somatostatin release from poly(lactide) microspheres prepared by a W/O/W solvent evaporation method. Journal of Controlled Release 36:1-2, pages 63-71.
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J.G. Nairm. 1995. Advances in Pharmaceutical Sciences Volume 7. Advances in Pharmaceutical Sciences Volume 7 93 219 .
HongKee Sah, Rohinton Toddywala & Yie W. Chien. (1994) The influence of biodegradable microcapsule formulations on the controlled release of a protein. Journal of Controlled Release 30:3, pages 201-211.
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K. Çiftçi, A.A. Hincal, H.S. Kaş, M.T. Ercan & Ş. Ruacan. (1994) Microspheres of 5-fluorouracil using poly(dl-lactic acid): in vitro release properties and distribution in mice after i.v. administration. European Journal of Pharmaceutical Sciences 1:5, pages 249-258.
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Yukio Aso, Sumie Yoshioka & Tadao Terao. (1993) Effects of storage on the physicochemical properties and release characteristics of progesterone-loaded poly(l-lactide) microspheres. International Journal of Pharmaceutics 93:1-3, pages 153-159.
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S. Izumikawa, S. Yoshioka, Y. Aso & Y. Takeda. (1991) Preparation of poly(l-lactide) microspheres of different crystalline morphology and effect of crystalline morphology on drug release rate. Journal of Controlled Release 15:2, pages 133-140.
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