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Research Article

Preparation of controlled release anticancer agents I: 5-fluorouracil-ethyl cellulose microspheres

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Pages 447-454 | Published online: 27 Sep 2008

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Haozhe Zhang, Berlinda Lim Kwee Hong, Xin Xu, Dong Wang, Zhenghua Song & Eng San Thian. (2023) An approach to mass produce peppermint oil-sodium alginate composite microcapsules by drop-on-demand system loaded with stabilized nanoemulsion. Materials Technology 38:1.
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Gitu Pandey, Sarita Kumari Yadav & Brahmeshwar Mishra. (2016) Preparation and characterization of isoniazid and lamivudine co-loaded polymeric microspheres. Artificial Cells, Nanomedicine, and Biotechnology 44:8, pages 1867-1877.
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Subheet Kumar Jain, Richa Puri, Mohit Mahajan, Subodh Yadav, C. M. Pathak & N. Ganesh. (2015) Nanovesicular carrier-based formulation for skin cancer targeting: evaluation of cytotoxicity, intracellular uptake, and preclinical anticancer activity. Journal of Drug Targeting 23:3, pages 244-256.
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Mesut Arici, Ozlem Topbas, Sinem Yaprak Karavana, Gokhan Ertan, Merih Sariisik & Cihat Ozturk. (2014) Preparation of naproxen–ethyl cellulose microparticles by spray-drying technique and their application to textile materials. Journal of Microencapsulation 31:7, pages 654-666.
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True L. Rogers & Dave Wallick. (2012) Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 3: Applications for microcapsules. Drug Development and Industrial Pharmacy 38:5, pages 521-539.
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True L. Rogers & Dave Wallick. (2011) Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: Techniques used to make microcapsules. Drug Development and Industrial Pharmacy 37:11, pages 1259-1271.
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N. Venkata Naga Jyothi, P. Muthu Prasanna, Suhas Narayan Sakarkar, K. Surya Prabha, P. Seetha Ramaiah & G. Y Srawan. (2010) Microencapsulation techniques, factors influencing encapsulation efficiency. Journal of Microencapsulation 27:3, pages 187-197.
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Azita Haddadi, Reza Aboofazeli, Mohammad Erfan & Effat Sadat Farboud. (2008) Topical delivery of urea encapsulated in biodegradable PLGA microparticles: O/W and W/O creams. Journal of Microencapsulation 25:6, pages 379-386.
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Azita Haddadi, Effat Sadat Farboud, Mohammad Erfan & Reza Aboofazeli. (2006) Preparation and characterization of biodegradable urea-loaded microparticles as an approach for transdermal delivery. Journal of Microencapsulation 23:6, pages 698-712.
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M. Saravanan, K. Bhaskar, G. Srinivasa Rao & M. D. Dhanaraju. (2003) Ibuprofen-loaded ethylcellulose/polystyrene microspheres: An approach to get prolonged drug release with reduced burst effect and low ethylcellulose content. Journal of Microencapsulation 20:3, pages 289-302.
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R. Fernandez-Urrusuno, J. M. Gines, E. Morillo. (2000) Development of controlled release formulations of alachlor in ethylcellulose. Journal of Microencapsulation 17:3, pages 331-342.
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F. L. Mi, Y. C Tseng, C. T Chen & S. S Shyu. (1997) Preparation and release properties of biodegradable chitin microcapsules: II. Sustained release of 6-mercaptopurine from chitin microcapsules. Journal of Microencapsulation 14:2, pages 211-223.
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J. D. Jonkman-De Vries, K. P. Flora, A. Bult & J. H. Beijnen. (1996) Pharmaceutical Development of (Investigational) Anticancer Agents for Parenteral Use-A Review. Drug Development and Industrial Pharmacy 22:6, pages 475-494.
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J. Akbuga & N. Bergİşadİ. (1996) 5-Fluorouracil-loaded chitosan microspheres: Preparation and release characteristics. Journal of Microencapsulation 13:2, pages 161-168.
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R. Narayani & K. Panduranga Rao. (1994) Controlled release of anticancer drug methotrexate from biodegradable gelatin microspheres. Journal of Microencapsulation 11:1, pages 69-77.
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C. Zinutti, F. Kedzierewicz, M. Hoffman & P. Maincent. (1994) Preparation and characterization of ethylcellulose microspheres containing 5-fluorouracil. Journal of Microencapsulation 11:5, pages 555-563.
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Basheer Al-kasmi, MHD. Bashir Alsirawan, Mais Bashimam & Hind El-zein. (2017) Mechanical microencapsulation: The best technique in taste masking for the manufacturing scale - Effect of polymer encapsulation on drug targeting. Journal of Controlled Release 260, pages 134-141.
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Qiao Wang, Aiping Fu, Hongliang Li, Jingquan Liu, Peizhi Guo, Xiu Song Zhao & Lin Hua Xia. (2014) Preparation of cellulose based microspheres by combining spray coagulating with spray drying. Carbohydrate Polymers 111, pages 393-399.
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M S Latha, A Jayakrishnan, K Rathinam & M Mohanty. (1994) Casein as a Carrier Matrix for 5-Fluorouracil: Drug Release from Microspheres, Drug-protein Conjugates and In-vivo Degradation of Microspheres in Rat Muscle. Journal of Pharmacy and Pharmacology 46:11, pages 858-862.
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S Santoyo, E.Ga de Jalón, P Ygartua, M.J Renedo & M.J Blanco-Prı́eto. (2002) Optimization of topical cidofovir penetration using microparticles. International Journal of Pharmaceutics 242:1-2, pages 107-113.
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E.G. de Jalón, M.J. Blanco-Prı́eto, P. Ygartua & Susana Santoyo. (2001) PLGA microparticles: possible vehicles for topical drug delivery. International Journal of Pharmaceutics 226:1-2, pages 181-184.
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K. C. Gupta & M. N. V. Ravi Kumar. (2000) Semi-interpenetrating polymer network beads of crosslinked chitosan-glycine for controlled release of chlorphenramine maleate. Journal of Applied Polymer Science 76:5, pages 672-683.
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Fwu-Long Mi, Chin-Ta Chen, Yuan-Cheng Tseng, Chih-Yang Kuan & Shin-Shing Shyu. (1997) Iron(III)-carboxymethylchitin microsphere for the pH-sensitive release of 6-mercaptopurine. Journal of Controlled Release 44:1, pages 19-32.
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R. Narayani & K. Panduranga Rao. (1996) Solid tumor chemotherapy using injectable gelatin microspheres containing free methotrexate and conjugated methotrexate. International Journal of Pharmaceutics 142:1, pages 25-32.
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C. Zinutti, F. Kedzierewicz, M. Hoffman, J.P. Benoit & P. Maincent. (1996) Influence of the casting solvent on the physico-chemical properties of 5-fluorouracil loaded microspheres. International Journal of Pharmaceutics 133:1-2, pages 97-105.
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K. Çiftçi, A.A. Hincal, H.S. Kaş, M.T. Ercan & Ş. Ruacan. (1994) Microspheres of 5-fluorouracil using poly(dl-lactic acid): in vitro release properties and distribution in mice after i.v. administration. European Journal of Pharmaceutical Sciences 1:5, pages 249-258.
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R. Narayani & K. Panduranga Rao. (1993) Preparation, characterisation and in vitro stability of hydrophilic gelatin microspheres using a gelatin-methotrexate conjugate. International Journal of Pharmaceutics 95:1-3, pages 85-91.
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