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Research Article

Process and formulation variables in the preparation of wax microparticles by a melt dispersion technique. I. Oil-in-water technique for water-insoluble drugs

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Pages 89-98 | Received 18 Apr 1991, Accepted 03 May 1991, Published online: 27 Sep 2008

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Aditi Nandy, Eliza Lee, Abhyuday Mandal, Raha Saremi & Suraj Sharma. (2020) Microencapsulation of retinyl palmitate by melt dispersion for cosmetic application. Journal of Microencapsulation 37:3, pages 205-219.
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Liandong Hu, Jianxue Yang, Wei Liu & Li Li. (2011) Preparation and evaluation of ibuprofen-loaded microemulsion for improvement of oral bioavailability. Drug Delivery 18:1, pages 90-95.
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Aida Gifani, Mojtaba Taghizadeh, Ali A. Seifkordi & Mehdi Ardjmand. (2009) Preparation and investigation the release behaviour of wax microspheres loaded with salicylic acid. Journal of Microencapsulation 26:6, pages 485-492.
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Séverine Jaspart, Géraldine Piel, Luc Delattre & Brigitte Evrard. (2005) Solid lipid microparticles: formulation, preparation, characterisation, drug release and applications. Expert Opinion on Drug Delivery 2:1, pages 75-87.
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Chul Soon Yong, Mi-Kyung Lee, Young-Joon Park, Kyung-Hwan Kong, Jing Ji Xuan, Ji-Hyun Kim, Jung-Ae Kim, Won Seok Lyoo, Sung Soo Han, Jong-Dal Rhee, Jong Oh Kim, Chae Ha Yang, Chong-Kook Kim & Han-Gon Choi. (2005) Enhanced Oral Bioavailability of Ibuprofen in Rats by Poloxamer Gel Using Poloxamer 188 and Menthol. Drug Development and Industrial Pharmacy 31:7, pages 615-622.
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Luigi Battaglia & Elena Ugazio. (2019) Lipid Nano- and Microparticles: An Overview of Patent-Related Research. Journal of Nanomaterials 2019, pages 1-22.
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Luisa Duque, Martin Körber & Roland Bodmeier. (2018) Impact of change of matrix crystallinity and polymorphism on ovalbumin release from lipid-based implants. European Journal of Pharmaceutical Sciences 117, pages 128-137.
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Muhammad Hanif, Hafeez Ullah Khan, Samina Afzal, Asif Mahmood, Safirah Maheen, Khurram Afzal, Nabila Iqbal, Mehwish Andleeb & Nazar Abbas. (2017) Sustained release biodegradable solid lipid microparticles: Formulation, evaluation and statistical optimization by response surface methodology. Acta Pharmaceutica 67:4, pages 441-461.
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Dilip M. Parikh. 2017. How to Optimize Fluid Bed Processing Technology. How to Optimize Fluid Bed Processing Technology 97 112 .
Omar Mady. (2016) Span 60 as a Microsphere Matrix: Preparation and in Vitro Characterization of Novel Ibuprofen‐Span 60 Microspheres. Journal of Surfactants and Detergents 20:1, pages 219-232.
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A. Goger, M. R. Thompson, J. L. Pawlak & D. J. W. Lawton. (2015) In Situ Rheological Measurement of an Aqueous Polyester Dispersion during Emulsification. Industrial & Engineering Chemistry Research 54:21, pages 5820-5829.
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Tobias Vöpel, Rebecca Scholz, Luca Davico, Magdalena Groß, Steffen Büning, Sabine Kareth, Eckhard Weidner & Simon Ebbinghaus. (2015) Infrared laser triggered release of bioactive compounds from single hard shell microcapsules. Chemical Communications 51:32, pages 6913-6916.
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Phuong Ha-Lien Tran, Thao Truong-Dinh Tran, Jun Bom Park & Beom-Jin Lee. (2011) Controlled Release Systems Containing Solid Dispersions: Strategies and Mechanisms. Pharmaceutical Research 28:10, pages 2353-2378.
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D. DOROUD, F. ZAHEDIFARD, A. VATANARA, A. R. NAJAFABADI & S. RAFATI. (2011) Cysteine proteinase type I, encapsulated in solid lipid nanoparticles induces substantial protection against Leishmania major infection in C57BL/6 mice . Parasite Immunology 33:6, pages 335-348.
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Nazar M. Ranjha, Hafeezullah Khan & Shahzad Naseem. (2010) Encapsulation and characterization of controlled release flurbiprofen loaded microspheres using beeswax as an encapsulating agent. Journal of Materials Science: Materials in Medicine 21:5, pages 1621-1630.
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M. Irfan, M. Seiler, I. Smirnova & W. Arlt. (2009) Melt Dispersion Method: Die Entwicklung von Prozess und Formulierung. Chemie Ingenieur Technik 81:8, pages 1119-1120.
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Michel Mellema. (2009) Co‐crystals of Beeswax and Various Vegetable Waxes with Sterols Studied by X‐ray Diffraction and Differential Scanning Calorimetry. Journal of the American Oil Chemists' Society 86:6, pages 499-505.
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U. Quintavalle, D. Voinovich, B. Perissutti, F. Serdoz, G. Grassi, A. Dal Col & M. Grassi. (2008) Preparation of sustained release co-extrudates by hot-melt extrusion and mathematical modelling of in vitro/in vivo drug release profiles. European Journal of Pharmaceutical Sciences 33:3, pages 282-293.
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Ming Guan Piao, Chan-Woo Yang, Dong Xun Li, Jong Oh Kim, Ki-Young Jang, Bong Kyu Yoo, Jung Ae Kim, Jong Soo Woo, Won Seok Lyoo, Sung Soo Han, Yong-Bok Lee, Dae-Duk Kim, Chul Soon Yong & Han Gon Choi. (2008) Preparation and in Vivo Evaluation of Piroxicam-Loaded Gelatin Microcapsule by Spray Drying Technique. Biological and Pharmaceutical Bulletin 31:6, pages 1284-1287.
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I. El-Gibaly & S.K. Abdel-Ghaffar. (2005) Effect of hexacosanol on the characteristics of novel sustained-release allopurinol solid lipospheres (SLS): factorial design application and product evaluation. International Journal of Pharmaceutics 294:1-2, pages 33-51.
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Ravindra Kamble, Manish Maheshwari, Anant Paradkar & Shivajirao Kadam. (2004) Melt solidification technique: Incorporation of higher wax content in ibuprofen beads. AAPS PharmSciTech 5:4, pages 75-83.
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Chul Soon Yong, Yu-Kyoung Oh, Se Hyun Jung, Jong-Dal Rhee, Ho-Dong Kim, Chong-Kook Kim & Han-Gon Choi. (2004) Preparation of ibuprofen-loaded liquid suppository using eutectic mixture system with menthol. European Journal of Pharmaceutical Sciences 23:4-5, pages 347-353.
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Umur Onal & Chris Langdon. (2004) Lipid spray beads for delivery of riboflavin to first-feeding fish larvae. Aquaculture 233:1-4, pages 477-493.
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Chul Soon Yong, Chae Ha Yang, Jong-Dal Rhee, Beom-Jin Lee, Dong-Chool Kim, Dae-Duk Kim, Chong-Kook Kim, Jun-Shik Choi & Han-Gon Choi. (2004) Enhanced rectal bioavailability of ibuprofen in rats by poloxamer 188 and menthol. International Journal of Pharmaceutics 269:1, pages 169-176.
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Anant Paradkar, Manish Maheshwari, Amit Kumar Tyagi, Bhaskar Chauhan & S. S. Kadam. (2003) Preparation and characterization of flurbiprofen beads by melt solidification technique. AAPS PharmSciTech 4:4, pages 514-522.
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Manish Maheshwari, Anant R Ketkar, Bhaskar Chauhan, Vinay B Patil & Anant R Paradkar. (2003) Preparation and characterization of ibuprofen–cetyl alcohol beads by melt solidification technique: effect of variables. International Journal of Pharmaceutics 261:1-2, pages 57-67.
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. (2003) Enhanced Solubility of Ibuprofen with Poloxamer 188 and Menthol. Journal of Korean Pharmaceutical Sciences 33:1, pages 57-60.
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Helmut Reithmeier, Joachim Herrmann & Achim Göpferich. (2001) Development and characterization of lipid microparticles as a drug carrier for somatostatin. International Journal of Pharmaceutics 218:1-2, pages 133-143.
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Margareta Emås & Håkan Nyqvist. (2000) Methods of studying aging and stabilization of spray-congealed solid dispersions with carnauba wax. 1. Microcalorimetric investigation. International Journal of Pharmaceutics 197:1-2, pages 117-127.
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