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Research Article

Biodegradable microspheres of poly(DL-lactic acid) containing piroxicam as a model drug for controlled release via the parenteral route

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Pages 449-460 | Received 18 May 1992, Accepted 08 Jun 1992, Published online: 27 Sep 2008

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Elif Sarıgöl, Sibel Bozdağ Pehlivan, Melike Ekizoğlu, Meral Sağıroğlu & Sema Çalış. (2017) Design and evaluation of gamma-sterilized vancomycin hydrochloride-loaded poly(ɛ-caprolactone) microspheres for the treatment of biofilm-based medical device-related osteomyelitis. Pharmaceutical Development and Technology 22:6, pages 706-714.
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Sung Rae Kim, Myoung Jin Ho, Sang Hyun Kim, Ha Ra Cho, Han Sol Kim, Yong Seok Choi, Young Wook Choi & Myung Joo Kang. (2016) Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection. Drug Design, Development and Therapy 10, pages 3779-3787.
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C. Martínez-Sancho, R. Herrero-Vanrell & S. Negro. (2003) Poly (D,L-lactide-co-glycolide) microspheres for long-term intravitreal delivery of aciclovir: Influence of fatty and non-fatty additives. Journal of Microencapsulation 20:6, pages 799-810.
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H. Selek, S. Sahin, M. T. Ercan, M. Sargon, A. A. Hincal & H. S. Kas. (2003) Formulation and in vitro/in vivo evaluation of terbutaline sulphate incorporated in PLGA (25/75) and L-PLA microspheres. Journal of Microencapsulation 20:2, pages 261-271.
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C. Mallard, J. Coudane, I. Rault, M. Vert. (2000) The use of additives to modulate the release of a sparingly water soluble drug entrapped in PLA50 microparticles: in vivo investigation. Journal of Microencapsulation 17:1, pages 95-110.
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D. F. BAIN, D. L. MUNDAY, A. SMITH. (1999) Modulation of rifampicin release from spray-dried microspheres using combinations of poly-(DL-lactide). Journal of Microencapsulation 16:3, pages 369-385.
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Martina B. Sintzel, Alain Merkli, Cyrus Tabatabay & Robert Gurny. (1997) Influence of Irradiation Sterilization on Polymers Used as Drug Carriers—A Review. Drug Development and Industrial Pharmacy 23:9, pages 857-878.
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B. Guiziou, D. J. Armstrong, P. N. C. Elliott, J. L. Ford & C. Rostron. (1996) Investigation of in-vitro release characteristics of NSAID-loaded polylactic acid microspheres. Journal of Microencapsulation 13:6, pages 701-708.
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. (1994) Literature Alerts. Journal of Microencapsulation 11:5, pages 586-600.
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Ida Idayu Muhamad, Suguna Selvakumaran, Mohd Harfiz Salehudin & Saiful Izwan Abd Razak. 2015. Handbook of Polymers for Pharmaceutical Technologies. Handbook of Polymers for Pharmaceutical Technologies 341 371 .
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S Bozdag, K Dillen, J Vandervoort & A Ludwig. (2005) The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D,L-lactide-glycolide) nanoparticles. Journal of Pharmacy and Pharmacology 57:6, pages 699-707.
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A. Sheikh Hassan, A. Sapin, A. Lamprecht, E. Emond, F. El Ghazouani & P. Maincent. (2009) Composite microparticles with in vivo reduction of the burst release effect. European Journal of Pharmaceutics and Biopharmaceutics 73:3, pages 337-344.
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Owen I. Corrigan & Xue Li. (2009) Quantifying drug release from PLGA nanoparticulates. European Journal of Pharmaceutical Sciences 37:3-4, pages 477-485.
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Christian Wischke & Steven P. Schwendeman. (2008) Principles of encapsulating hydrophobic drugs in PLA/PLGA microparticles. International Journal of Pharmaceutics 364:2, pages 298-327.
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Ming Li, Olivier Rouaud & Denis Poncelet. (2008) Microencapsulation by solvent evaporation: State of the art for process engineering approaches. International Journal of Pharmaceutics 363:1-2, pages 26-39.
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Abid Riaz Ahmed, Andrei Dashevsky & Roland Bodmeier. (2008) Reduction in burst release of PLGA microparticles by incorporation into cubic phase-forming systems. European Journal of Pharmaceutics and Biopharmaceutics 70:3, pages 765-769.
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Manoli Igartua, Rosa M Hernández, Jaiver Eduardo Rosas, Manuel Elkin Patarroyo & José Luís Pedraz. (2008) γ-Irradiation effects on biopharmaceutical properties of PLGA microspheres loaded with SPf66 synthetic vaccine. European Journal of Pharmaceutics and Biopharmaceutics 69:2, pages 519-526.
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Dušan Ražem & Branka Katušin-Ražem. (2008) The effects of irradiation on controlled drug delivery/controlled drug release systems. Radiation Physics and Chemistry 77:3, pages 288-344.
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Kyekyoon Kevin Kim & Daniel W. Pack. 2006. BioMEMS and Biomedical Nanotechnology. BioMEMS and Biomedical Nanotechnology 19 50 .
Magharla Dasaratha Dhanaraju, Damodaran Gopinath, Mohamed Rafiuddin Ahmed, Rajadas Jayakumar & Chandrasekar Vamsadhara. (2006) Characterization of polymeric poly(ε-caprolactone) injectable implant delivery system for the controlled delivery of contraceptive steroids. Journal of Biomedical Materials Research Part A 76A:1, pages 63-72.
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Emily J. Pollauf, Kyekyoon Kevin Kim & Daniel W. Pack. (2005) Small-Molecule Release from poly(D,L-Lactide)/Poly(D,L-Lactide-co-Glycolide) Composite Microparticles. Journal of Pharmaceutical Sciences 94:9, pages 2013-2022.
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Magharla Dasaratha Dhanaraju, Rajadas Jayakumar & Chandrasekar Vamsadhara. (2004) Influence of Manufacturing Parameters on Development of Contraceptive Steroid Loaded Injectable Microspheres. Chemical and Pharmaceutical Bulletin 52:8, pages 976-979.
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Cory Berkland, Martin King, Amanda Cox, Kyekyoon (Kevin) Kim & Daniel W Pack. (2002) Precise control of PLG microsphere size provides enhanced control of drug release rate. Journal of Controlled Release 82:1, pages 137-147.
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L. Montanari, F. Cilurzo, B. Conti, I. Genta, A. Groppo, L. Valvo, A. Faucitano & A. Buttafava. (2002) Gamma irradiation effects and EPR investigation on poly(lactide-co-glycolide) microspheres containing bupivacaine. Il Farmaco 57:6, pages 427-433.
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A.Ya. Polishchuk, M.V. Kazakova & G.E. Zaikov. (2018) Biodegradable Polymers and Their Use in Modern Medicine. 4. Microsystems for Controlled Release of Medicines. International Polymer Science and Technology 28:1, pages 40-44.
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M. Dunne, O.I. Corrigan & Z. Ramtoola. (2000) Influence of particle size and dissolution conditions on the degradation properties of polylactide-co-glycolide particles. Biomaterials 21:16, pages 1659-1668.
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Eliana Leo, Flavio Forni & Maria Teresa Bernabei. (2000) Surface drug removal from ibuprofen-loaded PLA microspheres. International Journal of Pharmaceutics 196:1, pages 1-9.
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É Kiss & E.I Vargha-Butler. (1999) Novel method to characterize the hydrolytic decomposition of biopolymer surfaces. Colloids and Surfaces B: Biointerfaces 15:3-4, pages 181-193.
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Detlev Mohr, Michael Wolff & Thomas Kissel. (1999) Gamma irradiation for terminal sterilization of 17β-estradiol loaded poly-( d , l -lactide-co-glycolide) microparticles. Journal of Controlled Release 61:1-2, pages 203-217.
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Patrick B O'Donnell & James W McGinity. (1997) Preparation of microspheres by the solvent evaporation technique. Advanced Drug Delivery Reviews 28:1, pages 25-42.
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