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Research Article

The Microsponge® Delivery System (MDS): a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives

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Pages 575-588 | Received 13 Mar 1995, Accepted 20 Nov 1995, Published online: 27 Sep 2008

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Amber Vyas, Avinesh Kumar Sonker & Bina Gidwani. (2014) Carrier-Based Drug Delivery System for Treatment of Acne. The Scientific World Journal 2014, pages 1-14.
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Sara BrennerDavid Schairer, MD Chouake, MD Nasir & Adam Friedman. 2013. The Clinical Nanomedicine Handbook. The Clinical Nanomedicine Handbook 85 194 .
K. P. Wilhelm, D. Wilhelm, C. Neumeister, I. Zsolt & U. Schwantes. (2012) Lack of irritative potential of nadifloxacin 1% when combined with other topical anti-acne agents. Clinical and Experimental Dermatology 37:2, pages 112-117.
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Sabyasachi Maiti, Santanu Kaity, Somasree Ray & Biswanath Sa. (2011) Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium. Acta Pharmaceutica 61:3, pages 257-270.
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Sonia Badreshia-Bansal & Vivek Bansal. 2011. Treatments for Skin of Color. Treatments for Skin of Color 3 23 .
Pearl E. Grimes. 2012. Color Atlas of Chemical Peels. Color Atlas of Chemical Peels 107 121 .
S. K. Jain & N. K. Jain. (2010) Multiparticulate carriers for sun-screening agents. International Journal of Cosmetic Science 32:2, pages 89-98.
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. 2010. Cosmeceutical Science in Clinical Practice. Cosmeceutical Science in Clinical Practice 32 39 .
J. Berth-Jones. 2010. Rook's Textbook of Dermatology. Rook's Textbook of Dermatology 1 52 .
A. M. Layton. 2010. Rook's Textbook of Dermatology. Rook's Textbook of Dermatology 1 89 .
Neil S Sadick, Mary P Lupo, Diane S Berson & Zoe Diana DraelosZoe Diana Draelos. 2010. Cosmeceutical Science in Clinical Practice. Cosmeceutical Science in Clinical Practice 32 39 .
Yanjun Zhao, Marc B. Brown & Stuart A. Jones. (2010) The Topical Delivery of Benzoyl Peroxide Using Elegant Dynamic Hydrofluoroalkane Foams. Journal of Pharmaceutical Sciences 99:3, pages 1384-1398.
Crossref
Saskia K. Klee, Mike Farwick & Peter Lersch. (2009) Triggered release of sensitive active ingredients upon response to the skin's natural pH. Colloids and Surfaces A: Physicochemical and Engineering Aspects 338:1-3, pages 162-166.
Crossref
Ferhan Sevgi, Aysu Yurdasiper, Buket Kaynarsoy, Ezgi Turunç, Tamer Güneri & Ayfer Yalçın. (2009) Studies on Mefenamic Acid Microparticles: Formulation, In Vitro Release, and In Situ Studies in Rats. AAPS PharmSciTech 10:1, pages 104-112.
Crossref
Sarah Küchler, Michal R. Radowski, Tobias Blaschke, Margitta Dathe, Johanna Plendl, Rainer Haag, Monika Schäfer-Korting & Klaus D. Kramer. (2009) Nanoparticles for skin penetration enhancement – A comparison of a dendritic core-multishell-nanotransporter and solid lipid nanoparticles. European Journal of Pharmaceutics and Biopharmaceutics 71:2, pages 243-250.
Crossref
Deep Chanchal & Saraf Swarnlata. (2008) Novel approaches in herbal cosmetics. Journal of Cosmetic Dermatology 7:2, pages 89-95.
Crossref
Olivier Sorg, S Kuenzli & J. H. Saurat. 2007. Retinoids and Carotenoids in Dermatology. Retinoids and Carotenoids in Dermatology 225 248 .
Richard Berger, Ronald Rizer, Alicia Barba, David Wilson, Daniel Stewart, Rachel Grossman, Marge Nighland & Jonathan Weiss. (2007) Tretinoin gel microspheres 0.04% versus 0.1% in adolescents and adults with mild to moderate acne vulgaris: A 12-week, multicenter, randomized, double-blind, parallel-group, phase IV trial. Clinical Therapeutics 29:6, pages 1086-1097.
Crossref
Mine Orlu, Erdal Cevher & Ahmet Araman. (2006) Design and evaluation of colon specific drug delivery system containing flurbiprofen microsponges. International Journal of Pharmaceutics 318:1-2, pages 103-117.
Crossref
M. Jelvehgari, M.R. Siahi-Shadbad, S. Azarmi, Gary P. Martin & Ali Nokhodchi. (2006) The microsponge delivery system of benzoyl peroxide: Preparation, characterization and release studies. International Journal of Pharmaceutics 308:1-2, pages 124-132.
Crossref
Ö.Özer, I. Özcan, E.Ö. Çetin, I. Tekmen, Ü. Sönmez, L. Kirilmaz & T. Güneri. (2006) Evaluation of in vitro release and skin irritation of benzoyl peroxide-containing products. Journal of Drug Delivery Science and Technology 16:6, pages 449-454.
Crossref
Subhash Saxena & Sergio Nacht. 2005. Delivery System Handbook for Personal Care and Cosmetic Products. Delivery System Handbook for Personal Care and Cosmetic Products 333 351 .
Nava Dayan. 2005. Delivery System Handbook for Personal Care and Cosmetic Products. Delivery System Handbook for Personal Care and Cosmetic Products 101 118 .
Andrea Krautheim & Harald P.M. Gollnick. (2004) Acne: Topical treatment. Clinics in Dermatology 22:5, pages 398-407.
Crossref
Jong Suk Lee, Yoon Sung Nam, Byung‐Young Kang, Sang‐Hoon Han & Ih‐Seop Chang. (2004) Vitamin A microencapsulation within poly(methyl methacrylate)‐ g ‐polyethylenimine microspheres: Localized proton buffering effect on vitamin A stability . Journal of Applied Polymer Science 92:1, pages 517-522.
Crossref
John E. WolfJr.Jr.. (2007) Maintenance Therapy for Acne Vulgaris: The Fine Balance Between Efficacy, Cutaneous Tolerability, and Adherence. SKINmed: Dermatology for the Clinician 3:1, pages 23-26.
Crossref
J. Berth‐Jones. 2004. Rook's Textbook of Dermatology. Rook's Textbook of Dermatology 3965 4016 .
N. B. Simpson & W. J. Cunliffe. 2004. Rook's Textbook of Dermatology. Rook's Textbook of Dermatology 2121 2196 .
Toshio Sakai, Hideki Sakai & Masahiko Abe. (2002) Dimpled Polymer Particles Prepared by a Single-Step Method in an Acoustic Field. Langmuir 18:10, pages 3763-3766.
Crossref
Susan Bershad. (2001) Developments in topical retinoid therapy for acne. Seminars in Cutaneous Medicine and Surgery 20:3, pages 154-161.
Crossref
Sharon Levy, Katharine Furst & Wendy Chern. (2001) A comparison of the skin permeation of three topical 0.5% fluorouracil formulations with that of a 5% formulation. Clinical Therapeutics 23:6, pages 901-907.
Crossref
Charity F. McConnell. (2000) Retinoid therapy for cutaneous disease: Current concepts. Current Problems in Dermatology 12:5, pages 246-248.
Crossref
W.J. Cunliffe, D.B. Holland, S.M. Clark & G.I. Stables. (2000) Comedogenesis: some new aetiological, clinical and therapeutic strategies. British Journal of Dermatology 142:6, pages 1084-1091.
Crossref
Richard P. Usatine & Martin A. Quan. (2000) PEARLS IN THE MANAGEMENT OF ACNE. Primary Care: Clinics in Office Practice 27:2, pages 289-308.
Crossref
Volkhard Jenning, Anja Gysler, Monika Schäfer-Korting & Sven H Gohla. (2000) Vitamin A loaded solid lipid nanoparticles for topical use: occlusive properties and drug targeting to the upper skin. European Journal of Pharmaceutics and Biopharmaceutics 49:3, pages 211-218.
Crossref
Volkhard Jenning, Andreas F Thünemann & Sven H Gohla. (2000) Characterisation of a novel solid lipid nanoparticle carrier system based on binary mixtures of liquid and solid lipids. International Journal of Pharmaceutics 199:2, pages 167-177.
Crossref
Diane M. Thiboutot. (2000) ACNE AND ROSACEA. Dermatologic Clinics 18:1, pages 63-71.
Crossref
Max Gloor, Joachim Fluhr & Karl ThomaM. Gloor. 2000. Dermatologische Externatherapie. Dermatologische Externatherapie 199 220 .
Gary M. White. (1999) Acne therapy. Disease-a-Month 45:8, pages 301-330.
Crossref
James J. Leyden. (1998) Topical treatment of acne vulgaris: Retinoids and cutaneous irritation. Journal of the American Academy of Dermatology 38:4, pages S1-S4.
Crossref

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