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Original Article

In vitro controlled release kinetics of local anaesthetics from poly(D, L-lactide) and poly(lactide-co-glycolide) microspheres

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Pages 243-255 | Received 01 Sep 1995, Accepted 16 Feb 1996, Published online: 26 Jun 2009

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Daniella Goder, Lior Matsliah, Shir Giladi, Liron Reshef-Steinberger, Idan Zin, Alon Shaul & Meital Zilberman. (2021) Mechanical, physical and biological characterization of soy protein films loaded with bupivacaine for wound healing applications. International Journal of Polymeric Materials and Polymeric Biomaterials 70:5, pages 345-355.
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Piyachat Roopngam, Kewei Liu, Lin Mei, Yi Zheng, Xianbing Zhu, Hsiang-I Tsai & Laiqiang Huang. (2016) Hepatitis C virus E2 protein encapsulation into poly d, l-lactic-co-glycolide microspheres could induce mice cytotoxic T-cell response. International Journal of Nanomedicine 11, pages 5361-5370.
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Vijaya B Joshi, Sean M Geary & Aliasger K Salem. (2013) Biodegradable particles as vaccine antigen delivery systems for stimulating cellular immune responses. Human Vaccines & Immunotherapeutics 9:12, pages 2584-2590.
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Zheng-Xing Su, Ya-Nan Shi, Le-Sheng Teng, Xiang Li, Le-xi Wang, Qing-Fan Meng, Li-Rong Teng & You-Xin Li. (2011) Biodegradable poly(D, L-lactide-co-glycolide) (PLGA) microspheres for sustained release of risperidone: Zero-order release formulation. Pharmaceutical Development and Technology 16:4, pages 377-384.
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Carolyn F Weiniger, M Golovanevski, M Sokolsky-Papkov & AJ Domb. (2010) Review of prolonged local anesthetic action. Expert Opinion on Drug Delivery 7:6, pages 737-752.
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Cuifang Cai, Shirui Mao, Oliver Germershaus, Andreas Schaper, Erik Rytting, Dawei Chen & Thomas Kissel. (2009) Influence of morphology and drug distribution on the release process of FITC-dextran-loaded microspheres prepared with different types of PLGA. Journal of Microencapsulation 26:4, pages 334-345.
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H. Selek, S. Sahin, M. T. Ercan, M. Sargon, A. A. Hincal & H. S. Kas. (2003) Formulation and in vitro/in vivo evaluation of terbutaline sulphate incorporated in PLGA (25/75) and L-PLA microspheres. Journal of Microencapsulation 20:2, pages 261-271.
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M. V. Bernardo, M. D. Blanco, C. Gómez, R. Olmo, J. M. Teijón. (2000) In vitro controlled release of bupivacaine from albumin microspheres and a co-matrix formed by microspheres in a poly(lactide-co-glycolide) film. Journal of Microencapsulation 17:6, pages 721-731.
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S. A. Elkheshen, M. A. Radwan. (2000) Sustained release microspheres of metoclopramide using poly(D,L-lactide-co-glycolide) copolymers. Journal of Microencapsulation 17:4, pages 425-435.
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Articles from other publishers (30)

Imran Vhora, Nirav Khatri & Ambikanandan Misra. 2021. Applications of Polymers in Drug Delivery. Applications of Polymers in Drug Delivery 221 261 .
Mingxin Ji, Guoliang Liu, Yunfeng Cui & Peng Zhao. (2020) Safety and efficacy concerns of modern strategies of local anesthetics delivery. 3 Biotech 10:8.
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Akhil Agrawal, Sandeep Rellegadla & Shikha Jain. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 87 129 .
Felicity Han, Andrew Whittaker, Steven Howdle, Andrew Naylor, Anjumn Shabir-Ahmed, Cheng Zhang & Maree Smith. (2018) Formulation of Bioerodible Ketamine Microparticles as an Analgesic Adjuvant Treatment Produced by Supercritical Fluid Polymer Encapsulation. Pharmaceutics 10:4, pages 264.
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Sarah D. Shepherd, Sandra C. O’Buckley, James M. Harrington, Laura G. Haines, Ginger D. Rothrock, Leah M. Johnson & Andrea G. Nackley. (2018) A moldable sustained release bupivacaine formulation for tailored treatment of postoperative dental pain. Scientific Reports 8:1.
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Ayhan Savaser, Ozgur Esim, Sevinc Kurbanoglu, Sibel A. Ozkan & Yalcin Ozkan. 2018. Organic Materials as Smart Nanocarriers for Drug Delivery. Organic Materials as Smart Nanocarriers for Drug Delivery 101 145 .
Laura Kearney, Derek Whelan, Brian D. O'Donnell & Anthony J.P. Clover. (2016) Novel methods of local anesthetic delivery in the perioperative and postoperative setting—potential for fibrin hydrogel delivery. Journal of Clinical Anesthesia 35, pages 246-252.
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Felicity Y. Han, Kristofer J. Thurecht, Ai-Leen Lam, Andrew K. Whittaker & Maree T. Smith. (2015) Novel Polymeric Bioerodable Microparticles for Prolonged-Release Intrathecal Delivery of Analgesic Agents for Relief of Intractable Cancer-Related Pain. Journal of Pharmaceutical Sciences 104:7, pages 2334-2344.
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C. F. Weiniger, L. Golovanevski, A. J. Domb & D. Ickowicz. (2012) Extended release formulations for local anaesthetic agents. Anaesthesia 67:8, pages 906-916.
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Pedro Paulo Tanaka, Maria Fernanda Torres & Sergio Bernardo Tenorio. (2012) Analysis of the Acute Cytotoxic Potential of Bupivacaine and 50% Enantiomeric Excess Bupivacaine (S75-R25) Incorporated into Microspheres in Rat Sciatic Nerves. Brazilian Journal of Anesthesiology 62:2, pages 223-234.
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Edward A. Shipton. (2012) New Formulations of Local Anaesthetics—Part I. Anesthesiology Research and Practice 2012, pages 1-11.
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Hideko T. Oyama, Yoshikazu Tanaka & Ayako Kadosaka. (2009) Rapid controlled hydrolytic degradation of poly(l-lactic acid) by blending with poly(aspartic acid-co-l-lactide). Polymer Degradation and Stability 94:9, pages 1419-1426.
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Kumar G. Janoria & Ashim K. Mitra. (2007) Effect of lactide/glycolide ratio on the in vitro release of ganciclovir and its lipophilic prodrug (GCV-monobutyrate) from PLGA microspheres. International Journal of Pharmaceutics 338:1-2, pages 133-141.
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Mohamed Al Malyan, Chiara Becchi, Lila Nikkola, Petrus Viitanen, Sergio Boncinelli, Federica Chiellini & Nureddin Ashammakhi. (2006) Polymer-Based Biodegradable Drug Delivery Systems in Pain Management. Journal of Craniofacial Surgery 17:2, pages 302-313.
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Jeffrey S. Wiggins, Mohammad K. Hassan, Kenneth A. Mauritz & Robson F. Storey. (2006) Hydrolytic degradation of poly(d,l-lactide) as a function of end group: Carboxylic acid vs. hydroxyl. Polymer 47:6, pages 1960-1969.
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F. Cilurzo, F. Selmin, V. Liberti & L. Montanari. (2005) Thermal characterization of poly(lactide-co-glycolide) microspheres containing bupivacaine base polymorphs. Journal of Thermal Analysis and Calorimetry 79:1, pages 9-12.
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S. Freiberg & X.X. Zhu. (2004) Polymer microspheres for controlled drug release. International Journal of Pharmaceutics 282:1-2, pages 1-18.
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Pen-Chung Chen, Yoon Jeong Park, Li-Chien Chang, Daniel S. Kohane, Robert H. Bartlett, Robert Langer & Victor C. Yang. (2004) Injectable microparticle-gel system for prolonged and localized lidocaine release. I.In vitro characterization. Journal of Biomedical Materials Research 70A:3, pages 412-419.
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Samaresh Ghosh. (2019) Recent research and development in synthetic polymer-based drug delivery systems. Journal of Chemical Research 2004:4, pages 241-246.
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F. Lagarce & J.P. Benoit. (2004) Sustained release formulations for spinal drug delivery. Journal of Drug Delivery Science and Technology 14:5, pages 331-343.
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Iwona Maszczynska Bonney, Dilek Sendil Keskin, Andrzej W. Lipkowski, Vasif Hasirci & Daniel B. Carr. 2004. Biomaterials. Biomaterials 209 219 .
M.V. Bernardo, M.D. Blanco, R.L. Sastre, C. Teijón & J.M. Teijón. (2003) Sustained release of bupivacaine from devices based on chitosan. Il Farmaco 58:11, pages 1187-1191.
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Youngtai Yoo, Hyun-Woo Shin & Byung-Guk Nam. (2003) Effect of Hydrophilic-Lipophilic balance of drugs on their release behavior from amphiphilic matrix. Macromolecular Research 11:4, pages 283-290.
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M.D Blanco, M.V Bernardo, C Teijón, R.L Sastre & J.M Teijón. (2003) Transdermal application of bupivacaine-loaded poly(acrylamide(A)-co-monomethyl itaconate) hydrogels. International Journal of Pharmaceutics 255:1-2, pages 99-107.
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Pascal Le Corre, Jean Pierre Estèbe, Rozenn Clément, Laure Du Plessis, François Chevanne, Claude Ecoffey & Roger Le Verge. (2002) Spray-dryed bupivacaine-loaded microspheres: in vitro evaluation and biopharmaceutics of bupivacaine following brachial plexus administration in sheep. International Journal of Pharmaceutics 238:1-2, pages 191-203.
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Daniel S. Kohane, Michael Lipp, Ramsey C. Kinney, Douglas C. Anthony, David N. Louis, Noah Lotan & Robert Langer. (2002) Biocompatibility of lipid-protein-sugar particles containing bupivacaine in the epineurium. Journal of Biomedical Materials Research 59:3, pages 450-459.
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Tze-Wen Chung, Yi-You Huang & Yi-Ze Liu. (2001) Effects of the rate of solvent evaporation on the characteristics of drug loaded PLLA and PDLLA microspheres. International Journal of Pharmaceutics 212:2, pages 161-169.
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Françoise Nielloud & Gilberte Marti-MestresV Gallardo, M Ruiz & A Delgado. 2000. Pharmaceutical Emulsions and Suspensions. Pharmaceutical Emulsions and Suspensions 409 464 .
M.D. Blanco, M.V. Bernardo, C. Gómez, E. Muñiz & J.M. Teijón. (1999) Bupivacaine-loaded comatrix formed by albumin microspheres included in a poly(lactide-co-glycolide) film: in vivo biocompatibility and drug release studies. Biomaterials 20:20, pages 1919-1924.
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Milan Polakovič, Tatiana Görner, Ruxandra Gref & Edith Dellacherie. (1999) Lidocaine loaded biodegradable nanospheres. Journal of Controlled Release 60:2-3, pages 169-177.
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