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Journal of Microencapsulation
Micro and Nano Carriers
Volume 14, 1997 - Issue 3
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Original Article

Insulin in w/o/w multiple emulsions: Biological activity after oral administration in normal and diabetic rats

A. Silva Cunha Faculdade de farmacia da Universidade Federal de Minas Gerais, Avenida Olegario Maciel, 2360, 30180-112, Belo, Horizonte/MG, Brazil
,
J. L. Grossiord Laboratoire de Physique Pharmaceutique, URA CNRS 1218, UFR des Sciences Pharmaceutiques, 5 rue Jean Baptiste Clément, 92296, Chaˇtenay-Malabry, France
,
F. Puisieux Laboratoire de Pharmacie Galénique et Biopharmacie, 92296, Chaˇtenay-Malabry, France
&
M. Seiller Laboratoire de Pharmacie Galénique et Biopharmacie, 92296, Chaˇtenay-Malabry, France
Pages 321-333 | Received 05 Dec 1995, Accepted 15 Feb 1996, Published online: 26 Jun 2009

Citations (26)

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Keizo Fukushima, Yukako Ito, Masahiro Ishihata, Nobuyuki Sugioka & Kanji Takada. (2011) Insulin micropiles comprising biodegradable polymers for production of a long-term hypoglycemic effect. Journal of Drug Targeting 19:3, pages 212-218.
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JacquelineM. Morais, OrlandoD. H. Santos & StigE. Friberg. (2010) Some Fundamentals of the One-Step Formation of Double Emulsions. Journal of Dispersion Science and Technology 31:8, pages 1019-1026.
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Marina Gallarate, Michele Trotta, Luigi Battaglia & Daniela Chirio. (2009) Preparation of solid lipid nanoparticles from W/O/W emulsions: Preliminary studies on insulin encapsulation. Journal of Microencapsulation 26:5, pages 394-402.
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Yukako Ito, Jun-Ichiro Yoshimitsu, Keiji Shiroyama, Nobuyuki Sugioka & Kanji Takada. (2006) Self-dissolving microneedles for the percutaneous absorption of EPO in mice. Journal of Drug Targeting 14:5, pages 255-261.
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M. M. G. Aguiar, J. M. Rodrigues$suffix/text()$suffix/text() & A. Silva Cunha. (2004) Encapsulation of insulin–cyclodextrin complex in PLGA microspheres: a new approach for prolonged pulmonary insulin delivery. Journal of Microencapsulation 21:5, pages 553-564.
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E. A. Hosny, H. I. Al-Shora & M. M. A. Elmazar. (2002) Effect of Bioadhesive Polymers, Sodium Salicylate, Polyoxyethylene-9-lauryl Ether, and Method of Preparation on the Relative Hypoglycemia Produced by Insulin Enteric-Coated Capsules in Diabetic Beagle Dogs. Drug Development and Industrial Pharmacy 28:5, pages 563-570.
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Gilberte Marti-Mestres & Françoise Nielloud. (2002) Emulsions in Health Care Applications—An Overview. Journal of Dispersion Science and Technology 23:1-3, pages 419-439.
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Isabel Gomez-Orellana & Duncan R Paton. (1998) Advances in the oral delivery of proteins. Expert Opinion on Therapeutic Patents 8:3, pages 223-234.
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Articles from other publishers (18)

Saehun Mun, Yongdoo Choi & Yong-Ro Kim. (2015) Lipase digestibility of the oil phase in a water-in-oil-in-water emulsion. Food Science and Biotechnology 24:2, pages 513-520.
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Martín Chávez-Páez, Carla M. Quezada, Laura Ibarra-Bracamontes, Héctor O. González-Ochoa & José Luis Arauz-Lara. (2012) Coalescence in Double Emulsions. Langmuir 28:14, pages 5934-5939.
Crossref
Keizo Fukushima, Ayaka Ise, Hiromi Morita, Ryo Hasegawa, Yukako Ito, Nobuyuki Sugioka & Kanji Takada. (2010) Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats. Pharmaceutical Research 28:1, pages 7-21.
Crossref
Keizo FukushimaTakenao YamazakiRyo HasegawaYukako ItoNobuyuki SugiokaKanji Takada. (2010) Pharmacokinetic and Pharmacodynamic Evaluation of Insulin Dissolving Microneedles in Dogs. Diabetes Technology & Therapeutics 12:6, pages 465-474.
Crossref
K. Fukushima, H. Nakane, Y. Ohhashi, Y. Ito, N. Sugioka & K. Takada. (2010) Evaluation of insulin self-dissolving micropiles by PK/PD analysis. Journal of Drug Delivery Science and Technology 20:5, pages 361-366.
Crossref
Edith C. Rojas, Nurettin Sahiner, Louise B. Lawson, Vijay T. John & Kyriakos D. Papadopoulos. (2006) Controlled release from a nanocarrier entrapped within a microcarrier. Journal of Colloid and Interface Science 301:2, pages 617-623.
Crossref
Yukako Ito, Eiji Hagiwara, Atsushi Saeki, Nobuyuki Sugioka & Kanji Takada. (2006) Feasibility of microneedles for percutaneous absorption of insulin. European Journal of Pharmaceutical Sciences 29:1, pages 82-88.
Crossref
Motohiro Shima, Miyono Tanaka, Takao Fujii, Kahori Egawa, Yukitaka Kimura, Shuji Adachi & Ryuichi Matsuno. (2006) Oral administration of insulin included in fine W/O/W emulsions to rats. Food Hydrocolloids 20:4, pages 523-531.
Crossref
Kai Lindenstruth & Bernd W. Müller. (2004) W/O/W multiple emulsions with diclofenac sodium. European Journal of Pharmaceutics and Biopharmaceutics 58:3, pages 621-627.
Crossref
Fabienne Cournarie, Marie-Pierre Savelli, Véronique Rosilio, Françoise Bretez, Christine Vauthier, Jean-Louis Grossiord & Monique Seiller. (2004) Insulin-loaded W/O/W multiple emulsions: comparison of the performances of systems prepared with medium-chain-triglycerides and fish oil. European Journal of Pharmaceutics and Biopharmaceutics 58:3, pages 477-482.
Crossref
Mingtan Hai, Kalia Bernath, Dan Tawfik & Shlomo Magdassi. (2004) Flow Cytometry: A New Method To Investigate the Properties of Water-in-Oil-in-Water Emulsions. Langmuir 20:6, pages 2081-2085.
Crossref
Héctor González-Ochoa, Laura Ibarra-Bracamontes & José Luis Arauz-Lara. (2003) Two-Stage Coalescence in Double Emulsions. Langmuir 19:19, pages 7837-7840.
Crossref
Taro OGISO, Natsuko FUNAHASHI, Yoshinori TSUKIOKA, Masahiro IWAKI, Tadatoshi TANINO & Tetsuyuki WADA. (2001) Oral Delivery of Synthetic Eel Calcitonin, Elcatonin, in Rats.. Biological and Pharmaceutical Bulletin 24:6, pages 656-661.
Crossref
Ranjana Mitra, Isabelle Pezron, Waihei A Chu & Ashim K Mitra. (2000) Lipid emulsions as vehicles for enhanced nasal delivery of insulin. International Journal of Pharmaceutics 205:1-2, pages 127-134.
Crossref
Yoshinori Onuki, Mariko Morishita, Kozo Takayama, Sinji Tokiwa, Yoshiyuki Chiba, Koichi Isowa & Tsuneji Nagai. (2000) In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption. International Journal of Pharmaceutics 198:2, pages 147-156.
Crossref
Malam Aboubakar, Patrick Couvreur, Huguette Pinto‐Alphandary, Bruno Gouritin, Bernard Lacour, Robert Farinotti, Francis Puisieux & Christine Vauthier. (2000) Insulin‐loaded nanocapsules for oral administration: In vitro and in vivo investigation. Drug Development Research 49:2, pages 109-117.
Crossref
Mariko Morishita, Ayako Matsuzawa, Kozo Takayama, Koichi Isowa & Tsuneji Nagai. (1998) Improving insulin enteral absorption using water-in-oil-in-water emulsion. International Journal of Pharmaceutics 172:1-2, pages 189-198.
Crossref
A. Silva-Cunha, J.L. Grossiord, F. Puisieux & M. Seiller. (1997) W/O/W multiple emulsions of insulin containing a protease inhibitor and an absorption enhancer: preparation, characterization and determination of stability towards proteases in vitro. International Journal of Pharmaceutics 158:1, pages 79-89.
Crossref

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