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Original Article

Adaptation to low pH modifies thermal and thermo-chemical responses of mammalian cells

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Pages 379-387 | Received 20 Feb 1986, Published online: 09 Jul 2009

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W. C. Dewey. (2009) Arrhenius relationships from the molecule and cell to the clinic. International Journal of Hyperthermia 25:1, pages 3-20.
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M. T. Hargis, C. W. Storck, E. Wickstrom, L. A. Yakubov, D. B. Leeper & R. A. Coss. (2004) Hsp27 anti-sense oligonucleotides sensitize the microtubular cytoskeleton of Chinese hamster ovary cells grown at low pH to 42°C-induced reorganization. International Journal of Hyperthermia 20:5, pages 491-502.
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R. A. Coss, C. W. Storck, P. R. Wachsberger, J. Reilly, D. B. Leeper, D. Berd & M. L. Wahl. (2004) Acute extracellular acidification reduces intracellular pH, 42°C-induction of heat shock proteins and clonal survival of human melanoma cells grown at pH 6.7. International Journal of Hyperthermia 20:1, pages 93-106.
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D. B. Leeper, K. Engin, J-H. Wang, J. R. Cater & D. J. Li. (1998) Effect of I.V. Glucose Versus Combined I.V. Plus Oral Glucose on Human Tumour Extracellular Ph for Potential Sensitization to Thermoradiotherapy. International Journal of Hyperthermia 14:3, pages 257-269.
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C. S. Owen, M. L. Wahl, P. M. Pooler, R. A. Coss & B. Leeper. (1998) Temporal association between alterations in proton extrusion and low pH adaptation. International Journal of Hyperthermia 14:2, pages 227-232.
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R. A. Coss, J. A. Messinger, M. L. Wahl, P. R. Wachsberger, D. B. Leeper & C. S. Owen. (1997) Bicarbonate-dependent proton extrusion in Chinese hamster ovary (CHO) cells adapted to growth at pH 6.7. International Journal of Hyperthermia 13:3, pages 325-336.
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C. S. Owen. (1996) Dependence of proton generation on aerobic or anaerobic metabolism and implications for tumour pH. International Journal of Hyperthermia 12:4, pages 495-499.
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M. W. Dewhirst. (1994) Future directions in hyperthermia biology. International Journal of Hyperthermia 10:3, pages 339-345.
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W. C. Dewey. (1994) Arrhenius relationships from the molecule and cell to the clinic. International Journal of Hyperthermia 10:4, pages 457-483.
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S. A. van de Merwe, A. P. van den Berg, B. B. R. Kroon, A. W. van den Berge, J. M. Klaase & J. van der Zee. (1993) Modification of human tumour and normal tissue pH during hyperthermic and normothermic antiblastic regional isolation perfusion for malignant melanoma: a pilot study. International Journal of Hyperthermia 9:2, pages 205-217.
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J. G. Rhee, H. A. Eddy, O. M. Salazar, J. C. Lyons & C. W. Song. (1991) A differential low pH effect on tumour cells grown in vivo and in vitro when treated with hyperthermia. International Journal of Hyperthermia 7:1, pages 75-84.
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Donald E. Thrall, Mark W. Dewhirst, Rodney L. Page, Thaddeus V. Samulski, Deboroah A. McLeod & James R. Oleson. (1990) A comparison of temperatures in canine solid tumours during local and whole-body hyperthermia administered alone and simultaneously. International Journal of Hyperthermia 6:2, pages 305-317.
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M. W. Dewhirst, D. M. Prescott, S. Clegg, T. V. Samulski, R. L. Page, D. E. Thrall, K. Leopold, G. Rosner, J. C. Acker & J. R. Oleson. (1990) The use of hydralazine to manipulate tumour temperatures during hyperthermia. International Journal of Hyperthermia 6:6, pages 971-983.
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R. Valdagni. (1990) International Consensus Meeting on Hyperthermia: Final Report Castel Ivano, Trento, Italy 2–6 May 1989. International Journal of Hyperthermia 6:5, pages 837-877.
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B. C. Schem, O. Mella & O. Dahl. (1989) Potentiation of combined BCNU and hyperthermia by pH reduction in vitro and hypertonic glucose in vivo in the BT4 rat glioma. International Journal of Hyperthermia 5:6, pages 707-715.
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M. Urano & N. Tanaka. (1989) The effect of preirradiated tumour bed on the response of a murine fibrosarcoma to elevated temperatures. International Journal of Hyperthermia 5:5, pages 617-624.
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Kimberley A. Ward & Rakesh K. Jain. (1988) Invited review: Response of tumours to hyperglycaemia: characterization, significance and role in hyperthermia. International Journal of Hyperthermia 4:3, pages 223-250.
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T. S. Herman, B. A. Teicher, M. Jochelson, J. Clark, G. Svensson & C. N. Coleman. (1988) Rationale for use of local hyperthermia with radiation therapy and selected anticancer drugs in locally advanced human malignancies. International Journal of Hyperthermia 4:2, pages 143-158.
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Chang W. Song, Heonjoo Park & Robert J. Griffin. 2001. Thermotherapy for Neoplasia, Inflammation, and Pain. Thermotherapy for Neoplasia, Inflammation, and Pain 394 407 .
Charles S. Owen, Patricia M. Pooler, Miriam L. Wahl, Ronald A. Coss & Dennis B. Leeper. (1997) Altered proton extrusion in cells adapted to growth at low extracellular pH. Journal of Cellular Physiology 173:3, pages 397-405.
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Miriam L. Wahl, Suzanne B. Bobyock, Dennis B. Leeper & Charles S. Owen. (1997) Effects of 42°C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH. International Journal of Radiation Oncology*Biology*Physics 39:1, pages 205-212.
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Scott K Alpard, Roger A Vertrees, Weike Tao, Donald J Deyo, Robert L BrunstonJRJR & Joseph B Zwischenberger. (2016) Therapeutic hyperthermia. Perfusion 11:6, pages 425-435.
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